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Mol Cell Biol. 1987 August; 7(8): 2977-2980

Genetic rescue of muscle defects associated with a mutant Drosophila melanogaster tropomyosin allele.

E A Fyrberg and C C Karlik

Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218.

ABSTRACT

We describe a genetic transformation system which should prove useful for investigating tropomyosin assembly and function. Muscle abnormalities associated with a defective tropomyosin allele were corrected by integrating the wild-type gene into germ line chromosomes. The transformation protocol permits application of directed mutagenesis techniques in investigations of contractile regulatory mechanisms.

Mol Cell Biol. 1987 August; 7(8): 2977-2980




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