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Mol Cell Biol. 1987 August; 7(8): 2985-2987

Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance.

D Fallows, R B Kent, D L Nelson, J R Emanuel, R Levenson and D E Housman

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.

ABSTRACT

We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase alpha 1 subunit gene was detected, suggesting that structural differences between the rodent and primate alpha 1 subunits determine the different ouabain sensitivities.

Mol Cell Biol. 1987 August; 7(8): 2985-2987




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