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Mol Cell Biol. 1987 September; 7(9): 3353-3357

Unique DNA repair properties of a xeroderma pigmentosum revertant.

J E Cleaver, F Cortés, L H Lutze, W F Morgan, A N Player and D L Mitchell

Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143.

ABSTRACT

A group A xeroderma pigmentosum revertant with normal sensitivity was created by chemical mutagenesis. It repaired (6-4) photoproducts normally but not pyrimidine dimers and had near normal levels of repair replication, sister chromatid exchange, and mutagenesis from UV light. The rate of UV-induced mutation in a shuttle vector, however, was as high as the rate in the parental xeroderma pigmentosum cell line.

Mol Cell Biol. 1987 September; 7(9): 3353-3357




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