This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shani, M Articles by Yoffe, O Search for Related Content PubMed PubMed Citation Articles by Shani, M Articles by Yoffe, O

 Previous Article  |  Next Article 

Mol Cell Biol. 1988 February; 8(2): 1006-1009

Expression of the rat myosin light-chain 2 gene in transgenic mice: stage specificity, developmental regulation, and interrelation with the endogenous gene.

Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

ABSTRACT

The expression of the rat skeletal myosin light-chain 2 gene in two transgenic strains was tissue specific and stage specific. However, the temporal regulation during development of the transgene was different from that of the endogenous gene. Surprisingly, in one strain, the expression of the transgene was associated with a significant down-regulation of the endogenous gene. The possible mechanisms to account for the suppression of the endogenous gene and the potential implications of this suppression are discussed.

This article has been cited by other articles:

• Ramakrishnan, S. N., Lau, P., Burke, L. J., Muscat, G. E. O. (2005). Rev-erb{beta} Regulates the Expression of Genes Involved in Lipid Absorption in Skeletal Muscle Cells: EVIDENCE FOR CROSS-TALK BETWEEN ORPHAN NUCLEAR RECEPTORS AND MYOKINES. J. Biol. Chem. 280: 8651-8659 [Abstract] [Full Text]  
• Lau, P., Nixon, S. J., Parton, R. G., Muscat, G. E. O. (2004). ROR{alpha} Regulates the Expression of Genes Involved in Lipid Homeostasis in Skeletal Muscle Cells: CAVEOLIN-3 AND CPT-1 ARE DIRECT TARGETS OF ROR. J. Biol. Chem. 279: 36828-36840 [Abstract] [Full Text]  
• Gunning, P., Ferguson, V, Brennan, K., Hardeman, E. (2001). Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle. J. Cell Sci. 114: 513-524 [Abstract]  
• Jaenisch, R (1988). Transgenic animals. Science 240: 1468-1474 [Abstract]