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Mol Cell Biol. 1988 March; 8(3): 1380-1384

Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111.

ABSTRACT

Wild-type simian virus 40 large T antigen is very effective at blocking adipocyte differentiation in 3T3-F442A cells as assayed by triglyceride accumulation, induction of glycerophosphate dehydrogenase activity, and expression of mRNAs for glycerophosphate dehydrogenase, the adipocyte serine protease adipsin, and the putative lipid-binding protein adipocyte P2. Point mutants defective for either origin-specific DNA binding or transformation blocked differentiation as completely as wild type.

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