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Mol Cell Biol. 1988 April; 8(4): 1677-1683

Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.

Molecular Genetics Section, National Cancer Institute, Bethesda, Maryland 20892.

ABSTRACT

We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.

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