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Characterization of antigen receptor response elements within the interleukin-2 enhancer.

Department of Pathology, Stanford University School of Medicine, California 94305.

ABSTRACT

T-cell activation and induction of interleukin-2 (IL-2) expression in human T lymphocytes require both interaction of foreign antigen with the T-cell antigen receptor and protein kinase C (PKC) stimulation. Agents such as phorbol 12-myristate 13-acetate (PMA) that stimulate PKC augment the effects of antigen but are not sufficient for IL-2 activation. By analysis of deletion mutants, we identified three DNA sequences extending from -73 to -89, -217 to -255, and -263 to -279, designated IL-2 sites A, D, and E, respectively, that are required for maximal induction of IL-2 expression. One of these regions, site E, interacted with a protein (NF-IL-2E) present only in the nuclei of cells which have been stimulated. The other two sequences interacted with a protein (NF-IL-2A) that is constitutively expressed in T cells. When multiple tandem copies of either the E site or the A site were placed upstream of the gamma-fibrinogen promoter, they activated expression via this promoter in response to signals initiated at the antigen receptor but not following PMA stimulation. For this reason, we denoted them antigen receptor response elements. The uncoupling of antigen receptor and PKC requirements in these studies indicates that these signal pathways are, at least in part, distinct and integrated at the level of the gene.

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• Smith, J. L., Collins, I., Chandramouli, G. V. R., Butscher, W. G., Zaitseva, E., Freebern, W. J., Haggerty, C. M., Doseeva, V., Gardner, K. (2003). Targeting Combinatorial Transcriptional Complex Assembly at Specific Modules within the Interleukin-2 Promoter by the Immunosuppressant SB203580. J. Biol. Chem. 278: 41034-41046 [Abstract] [Full Text]  
• Schubert, W., Yang, X. Y., Yang, T. T.C., Factor, S. M., Lisanti, M. P., Molkentin, J. D., Rincon, M., Chow, C.-W. (2003). Requirement of transcription factor NFAT in developing atrial myocardium. J. Cell Biol. 161: 861-874 [Abstract] [Full Text]  
• Yang, T. T. C., Chow, C.-W. (2003). Transcription Cooperation by NFAT{middle dot}C/EBP Composite Enhancer Complex. J. Biol. Chem. 278: 15874-15885 [Abstract] [Full Text]  
• Antonsson, A., Hughes, K., Edin, S., Grundstrom, T. (2003). Regulation of c-Rel Nuclear Localization by Binding of Ca2+/Calmodulin. Mol. Cell. Biol. 23: 1418-1427 [Abstract] [Full Text]  
• Decker, E. L., Nehmann, N., Kampen, E., Eibel, H., Zipfel, P. F., Skerka, C. (2003). Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res 31: 911-921 [Abstract] [Full Text]  
• Sheridan, C. M., Heist, E. K., Beals, C. R., Crabtree, G. R., Gardner, P. (2002). Protein Kinase A Negatively Modulates the Nuclear Accumulation of NF-ATc1 by Priming for Subsequent Phosphorylation by Glycogen Synthase Kinase-3. J. Biol. Chem. 277: 48664-48676 [Abstract] [Full Text]  
• Ayroldi, E., Zollo, O., Macchiarulo, A., Di Marco, B., Marchetti, C., Riccardi, C. (2002). Glucocorticoid-Induced Leucine Zipper Inhibits the Raf-Extracellular Signal-Regulated Kinase Pathway by Binding to Raf-1. Mol. Cell. Biol. 22: 7929-7941 [Abstract] [Full Text]  
• Attema, J. L., Reeves, R., Murray, V., Levichkin, I., Temple, M. D., Tremethick, D. J., Shannon, M. F. (2002). The Human IL-2 Gene Promoter Can Assemble a Positioned Nucleosome That Becomes Remodeled Upon T Cell Activation. J. Immunol. 169: 2466-2476 [Abstract] [Full Text]  
• San-Antonio, B., Iniguez, M. A., Fresno, M. (2002). Protein Kinase Czeta Phosphorylates Nuclear Factor of Activated T Cells and Regulates Its Transactivating Activity. J. Biol. Chem. 277: 27073-27080 [Abstract] [Full Text]  
• Yang, T. T. C., Xiong, Q., Enslen, H., Davis, R. J., Chow, C.-W. (2002). Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases. Mol. Cell. Biol. 22: 3892-3904 [Abstract] [Full Text]  
• Iwashima, M., Takamatsu, M., Yamagishi, H., Hatanaka, Y., Huang, Y.-Y., McGinty, C., Yamasaki, S., Koike, T. (2002). Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression. Proc. Natl. Acad. Sci. USA 99: 4544-4549 [Abstract] [Full Text]  
• HUNTER, R. B., STEVENSON, E. J., KONCAREVIC, A., MITCHELL-FELTON, H., ESSIG, D. A., KANDARIAN, S. C. (2002). Activation of an alternative NF-{kappa}B pathway in skeletal muscle during disuse atrophy. FASEB J. 16: 529-538 [Abstract] [Full Text]  
• Jimenez, J. L., Punzon, C., Navarro, J., Munoz-Fernandez, M. A., Fresno, M. (2001). Phosphodiesterase 4 Inhibitors Prevent Cytokine Secretion by T Lymphocytes by Inhibiting Nuclear Factor-kappa B and Nuclear Factor of Activated T Cells Activation. J. Pharmacol. Exp. Ther. 299: 753-759 [Abstract] [Full Text]  
• Holland, S. J., Liao, X. C., Mendenhall, M. K., Zhou, X., Pardo, J., Chu, P., Spencer, C., Fu, A., Sheng, N., Yu, P., Pali, E., Nagin, A., Shen, M., Yu, S., Chan, E., Wu, X., Li, C., Woisetschlager, M., Aversa, G., Kolbinger, F., Bennett, M. K., Molineaux, S., Luo, Y., Payan, D. G., Mancebo, H. S.Y., Wu, J. (2001). Functional Cloning of Src-like Adapter Protein-2 (SLAP-2), a Novel Inhibitor of Antigen Receptor Signaling. J. Exp. Med. 194: 1263-1276 [Abstract] [Full Text]  
• Yang, T., Davis, R. J., Chow, C.-W. (2001). Requirement of Two NFATc4 Transactivation Domains for CBP Potentiation. J. Biol. Chem. 276: 39569-39576 [Abstract] [Full Text]  
• Finch, R. J., Fields, P. E., Greenberg, P. D. (2001). A Transcriptional Block in the IL-2 Promoter at the -150 AP-1 Site in Effector CD8+ T Cells. J. Immunol. 166: 6530-6536 [Abstract] [Full Text]  
• Baker, J. E., Majeti, R., Tangye, S. G., Weiss, A. (2001). Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase C{gamma}1 Phosphorylation. Mol. Cell. Biol. 21: 2393-2403 [Abstract] [Full Text]  
• Gonzalez, E., Punzon, C., Gonzalez, M., Fresno, M. (2001). HIV-1 Tat Inhibits IL-2 Gene Transcription Through Qualitative and Quantitative Alterations of the Cooperative Rel/AP1 Complex Bound to the CD28RE/AP1 Composite Element of the IL-2 Promoter. J. Immunol. 166: 4560-4569 [Abstract] [Full Text]  
• Cianferoni, A., Schroeder, J. T., Kim, J., Schmidt, J. W., Lichtenstein, L. M., Georas, S. N., Casolaro, V. (2001). Selective inhibition of interleukin-4 gene expression in human T cells by aspirin. Blood 97: 1742-1749 [Abstract] [Full Text]  
• Parra, E., Mustelin, T., Dohlsten, M., Mercola, D. (2001). Identification of a CD28 Response Element in the CD40 Ligand Promoter. J. Immunol. 166: 2437-2443 [Abstract] [Full Text]  
• Yang, W.-C., Ghiotto, M., Castellano, R., Collette, Y., Auphan, N., Nunes, J. A., Olive, D. (2000). Role of Tec kinase in nuclear factor of activated T cells signaling. Int Immunol 12: 1547-1552 [Abstract] [Full Text]  
• Trama, J., Lu, Q., Hawley, R. G., Ho, S. N. (2000). The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner. J. Immunol. 165: 4884-4894 [Abstract] [Full Text]  
• Swoap, S. J., Hunter, R. B., Stevenson, E. J., Felton, H. M., Kansagra, N. V., Lang, J. M., Esser, K. A., Kandarian, S. C. (2000). The calcineurin-NFAT pathway and muscle fiber-type gene expression. Am. J. Physiol. Cell Physiol. 279: C915-C924 [Abstract] [Full Text]  
• Michel, F., Mangino, G., Attal-Bonnefoy, G., Tuosto, L., Alcover, A., Roumier, A., Olive, D., Acuto, O. (2000). CD28 Utilizes Vav-1 to Enhance TCR-Proximal Signaling and NF-AT Activation. J. Immunol. 165: 3820-3829 [Abstract] [Full Text]  
• Thomas, L. H., Wickremasinghe, M. I. Y., Sharland, M., Friedland, J. S. (2000). Synergistic Upregulation of Interleukin-8 Secretion from Pulmonary Epithelial Cells by Direct and Monocyte-Dependent Effects of Respiratory Syncytial Virus Infection. J. Virol. 74: 8425-8433 [Abstract] [Full Text]  
• Chow, C.-W., Dong, C., Flavell, R. A., Davis, R. J. (2000). c-Jun NH2-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1. Mol. Cell. Biol. 20: 5227-5234 [Abstract] [Full Text]  
• Glimcher, L. H., Murphy, K. M. (2000). Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14: 1693-1711 [Full Text]  
• del Arco, P. G., Martinez-Martinez, S., Maldonado, J. L., Ortega-Perez, I., Redondo, J. M. (2000). A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp. J. Biol. Chem. 275: 13872-13878 [Abstract] [Full Text]  
• Huang, C., Mattjus, P., Ma, W.-y., Rincon, M., Chen, N.-y., Brown, R. E., Dong, Z. (2000). Involvement of Nuclear Factor of Activated T Cells Activation in UV Response. EVIDENCE FROM CELL CULTURE AND TRANSGENIC MICE. J. Biol. Chem. 275: 9143-9149 [Abstract] [Full Text]  
• Boerth, N. J., Judd, B. A., Koretzky, G. A. (2000). Functional Association between SLAP-130 and SLP-76 in Jurkat T Cells. J. Biol. Chem. 275: 5143-5152 [Abstract] [Full Text]  
• Chow, C.-W., Davis, R. J. (2000). Integration of Calcium and Cyclic AMP Signaling Pathways by 14-3-3. Mol. Cell. Biol. 20: 702-712 [Abstract] [Full Text]  
• Chen, R., Burke, T. F., Cumberland, J. E., Brummet, M., Beck, L. A., Casolaro, V., Georas, S. N. (2000). Glucocorticoids Inhibit Calcium- and Calcineurin-Dependent Activation of the Human IL-4 Promoter. J. Immunol. 164: 825-832 [Abstract] [Full Text]  
• Ranger, A. M., Gerstenfeld, L. C., Wang, J., Kon, T., Bae, H., Gravallese, E. M., Glimcher, M. J., Glimcher, L. H. (2000). The Nuclear Factor of Activated T Cells (NFAT) Transcription Factor NFATp (NFATc2) Is a Repressor of Chondrogenesis. J. Exp. Med. 191: 9-22 [Abstract] [Full Text]  
• Weiss, L., Whitmarsh, A. J., Yang, D. D., Rincon, M., Davis, R. J., Flavell, R. A. (2000). Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation. J. Exp. Med. 191: 139-146 [Abstract] [Full Text]  
• Underhill, D. M., Bassetti, M., Rudensky, A., Aderem, A. (1999). Dynamic Interactions of Macrophages with T Cells during Antigen Presentation. J. Exp. Med. 190: 1909-1914 [Abstract] [Full Text]  
• Civil, A., Rensink, I., Aarden, L. A., Verweij, C. L. (1999). Functional Disparity of Distinct CD28 Response Elements toward Mitogenic Responses. J. Biol. Chem. 274: 34369-34374 [Abstract] [Full Text]  
• Wickremasinghe, M. I., Thomas, L. H., Friedland, J. S. (1999). Pulmonary Epithelial Cells are a Source of IL-8 in the Response to Mycobacterium tuberculosis: Essential Role of IL-1 from Infected Monocytes in a NF-{kappa}B-Dependent Network. J. Immunol. 163: 3936-3947 [Abstract] [Full Text]  
• Kasibhatla, S., Tailor, P., Bonefoy-Berard, N., Mustelin, T., Altman, A., Fotedar, A. (1999). Jun Kinase Phosphorylates and Regulates the DNA Binding Activity of an Octamer Binding Protein, T-Cell Factor beta 1. Mol. Cell. Biol. 19: 2021-2031 [Abstract] [Full Text]  
• Armesilla, A. L., Lorenzo, E., Gomez del Arco, P., Martinez-Martinez, S., Alfranca, A., Redondo, J. M. (1999). Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T Cells in Human Endothelial Cells: a Role for Tissue Factor Gene Expression. Mol. Cell. Biol. 19: 2032-2043 [Abstract] [Full Text]  
• Chow, C.-W., Rincon, M., Davis, R. J. (1999). Requirement for Transcription Factor NFAT in Interleukin-2 Expression. Mol. Cell. Biol. 19: 2300-2307 [Abstract] [Full Text]  
• Hettmann, T., DiDonato, J., Karin, M., Leiden, J. M. (1999). An Essential Role for Nuclear Factor kappa B in Promoting Double Positive Thymocyte Apoptosis. J. Exp. Med. 189: 145-158 [Abstract] [Full Text]  
• Sweetser, M. T., Hoey, T., Sun, Y.-L., Weaver, W. M., Price, G. A., Wilson, C. B. (1998). The Roles of Nuclear Factor of Activated T Cells and Ying-Yang 1 in Activation-induced Expression of the Interferon-gamma Promoter in T Cells. J. Biol. Chem. 273: 34775-34783 [Abstract] [Full Text]  
• Ho, I-C., Kim, J. H.-J., Rooney, J. W., Spiegelman, B. M., Glimcher, L. H. (1998). A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis. Proc. Natl. Acad. Sci. USA 95: 15537-15541 [Abstract] [Full Text]  
• Barz, C., Nagel, T., Truitt, K. E., Imboden, J. B. (1998). Mutational Analysis of CD28-Mediated Costimulation of Jun-N-Terminal Kinase and IL-2 Production. J. Immunol. 161: 5366-5372 [Abstract] [Full Text]  
• Haughn, L., Leung, B., Boise, L., Veillette, A., Thompson, C., Julius, M. (1998). Interleukin 2-mediated Uncoupling of T Cell Receptor alpha /beta from CD3 Signaling. J. Exp. Med. 188: 1575-1586 [Abstract] [Full Text]  
• Decker, E. L., Skerka, C., Zipfel, P. F. (1998). The Early Growth Response Protein (EGR-1) Regulates Interleukin-2 Transcription by Synergistic Interaction with the Nuclear Factor of Activated T Cells. J. Biol. Chem. 273: 26923-26930 [Abstract] [Full Text]  
• Sunder-Plassmann, R., Reinherz, E. L. (1998). A p56lck-independent Pathway of CD2 Signaling Involves Jun Kinase. J. Biol. Chem. 273: 24249-24257 [Abstract] [Full Text]  
• Riesbeck, K., Forsgren, A., Henriksson, A., Bredberg, A. (1998). Ciprofloxacin Induces an Immunomodulatory Stress Response in Human T Lymphocytes. Antimicrob. Agents Chemother. 42: 1923-1930 [Abstract] [Full Text]  
• Boss, V., Wang, X., Koppelman, L. F., Xu, K., Murphy, T. J. (1998). Histamine Induces Nuclear Factor of Activated T Cell-Mediated Transcription and Cyclosporin A-Sensitive Interleukin-8 mRNA Expression in Human Umbilical Vein Endothelial Cells. Mol. Pharmacol. 54: 264-272 [Abstract] [Full Text]  
• Boss, V., Abbott, K. L., Wang, X.-F., Pavlath, G. K., Murphy, T. J. (1998). The Cyclosporin A-sensitive Nuclear Factor of Activated T Cells (NFAT) Proteins Are Expressed in Vascular Smooth Muscle Cells. DIFFERENTIAL LOCALIZATION OF NFAT ISOFORMS AND INDUCTION OF NFAT-MEDIATED TRANSCRIPTION BY PHOSPHOLIPASE C-COUPLED CELL SURFACE RECEPTORS. J. Biol. Chem. 273: 19664-19671 [Abstract] [Full Text]  
• Thomas, L. H., Friedland, J. S., Sharland, M., Becker, S. (1998). Respiratory Syncytial Virus-Induced RANTES Production from Human Bronchial Epithelial Cells Is Dependent on Nuclear Factor-{kappa}B Nuclear Binding and Is Inhibited by Adenovirus-Mediated Expression of Inhibitor of {kappa}B{alpha}. J. Immunol. 161: 1007-1016 [Abstract] [Full Text]  
• Ballester, A., Velasco, A., Tobena, R., Alemany, S. (1998). Cot Kinase Activates Tumor Necrosis Factor-alpha Gene Expression in a Cyclosporin A-resistant Manner. J. Biol. Chem. 273: 14099-14106 [Abstract] [Full Text]  
• Navarro, J., Punzon, C., Jimenez, J. L., Fernandez-Cruz, E., Pizarro, A., Fresno, M., Munoz-Fernandez, M. A. (1998). Inhibition of Phosphodiesterase Type IV Suppresses Human Immunodeficiency Virus Type 1 Replication and Cytokine Production in Primary T Cells: Involvement of NF-kappa B and NFAT. J. Virol. 72: 4712-4720 [Abstract] [Full Text]  
• Parra, E., McGuire, K., Hedlund, G., Dohlsten, M. (1998). Overexpression of p65 and c-Jun Substitutes for B7-1 Costimulation by Targeting the CD28RE Within the IL-2 Promoter. J. Immunol. 160: 5374-5381 [Abstract] [Full Text]  
• Kennedy, A. P., Sekulic, A., Irvin, B. J., Nilson, A. E., Dilworth, S. M., Abraham, R. T. (1998). Polyomavirus Middle T Antigen as a Probe for T Cell Antigen Receptor-coupled Signaling Pathways. J. Biol. Chem. 273: 11505-11513 [Abstract] [Full Text]  
• Irving, B. A., Alt, F. W., Killeen, N. (1998). Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains. Science 280: 905-908 [Abstract] [Full Text]  
• Hata, D., Kitaura, J., Hartman, S. E., Kawakami, Y., Yokota, T., Kawakami, T. (1998). Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells. DEPENDENCE ON THE c-Jun N-TERMINAL KINASE ACTIVATION PATHWAY. J. Biol. Chem. 273: 10979-10987 [Abstract] [Full Text]  
• Tsatsanis, C., Patriotis, C., Bear, S. E., Tsichlis, P. N. (1998). The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines. Proc. Natl. Acad. Sci. USA 95: 3827-3832 [Abstract] [Full Text]  
• Williams, B. L., Schreiber, K. L., Zhang, W., Wange, R. L., Samelson, L. E., Leibson, P. J., Abraham, R. T. (1998). Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line. Mol. Cell. Biol. 18: 1388-1399 [Abstract] [Full Text]  
• Butscher, W. G., Powers, C., Olive, M., Vinson, C., Gardner, K. (1998). Coordinate Transactivation of the Interleukin-2 CD28 Response Element by c-Rel and ATF-1/CREB2. J. Biol. Chem. 273: 552-560 [Abstract] [Full Text]  
• Gringhuis, S. I., de Leij, L. F. M. H., Wayman, G. A., Tokumitsu, H., Vellenga, E. (1997). The Ca2+/Calmodulin-dependent Kinase Type IV Is Involved in the CD5-mediated Signaling Pathway in Human T Lymphocytes. J. Biol. Chem. 272: 31809-31820 [Abstract] [Full Text]  
• Gringhuis, S. I., F.M.H. de Leij, L., Verschuren, E. W., Borger, P., Vellenga, E. (1997). Interleukin-7 Upregulates the Interleukin-2-Gene Expression in Activated Human T Lymphocytes at the Transcriptional Level by Enhancing the DNA Binding Activities of Both Nuclear Factor of Activated T Cells and Activator Protein-1. Blood 90: 2690-2700 [Abstract] [Full Text]  
• Oiry, C., Gagne, D., Cottin, E., Bernad, N., Galleyrand, J.-C., Bergé, G., Lignon, M.-F., Eldin, P., Le Cunff, M., Léger, J., Clerc, P., Fourmy, D., Martinez, J. (1997). CholecystokininB Receptor from Human Jurkat Lymphoblastic T Cells Is Involved in Activator Protein-1-Responsive Gene Activation. Mol. Pharmacol. 52: 292-299 [Abstract] [Full Text]  
• Sun, L. J., Peterson, B. R., Verdine, G. L. (1997). Dual role of the nuclear factor of activated T cells insert region in DNA recognition and cooperative contacts to activator protein 1. Proc. Natl. Acad. Sci. USA 94: 4919-4924 [Abstract] [Full Text]  
• Beals, C R, Clipstone, N A, Ho, S N, Crabtree, G R (1997). Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.. Genes Dev. 11: 824-834 [Abstract]  
• Nirula, A., Moore, D. J., Gaynor, R. B. (1997). Constitutive Binding of the Transcription Factor Interleukin-2 (IL-2) Enhancer Binding Factor to the IL-2 Promoter. J. Biol. Chem. 272: 7736-7745 [Abstract] [Full Text]  
• Ceci, J D, Patriotis, C P, Tsatsanis, C, Makris, A M, Kovatch, R, Swing, D A, Jenkins, N A, Tsichlis, P N, Copeland, N G (1997). Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.. Genes Dev. 11: 688-700 [Abstract]  
• Mege, D., Di Bartolo, V., Germain, V., Tuosto, L., Michel, F., Acuto, O. (1996). Mutation of Tyrosines 492/493 in the Kinase Domain of ZAP-70 Affects Multiple T-cell Receptor Signaling Pathways. J. Biol. Chem. 271: 32644-32652 [Abstract] [Full Text]  
• Peterson, B. R., Sun, L. J., Verdine, G. L. (1996). A critical arginine residue mediates cooperativity in the contact interface between transcription factors NFAT and AP-1. Proc. Natl. Acad. Sci. USA 93: 13671-13676 [Abstract] [Full Text]  
• delArco, P., Martinez-Martinez, S., Calvo, V., Armesilla, A., Redondo, J. (1996). JNK (c-Jun NH2-terminal Kinase) Is a Target for Antioxidants in T Lymphocytes. J. Biol. Chem. 271: 26335-26340 [Abstract] [Full Text]  
• Park, J., Takeuchi, A., Sharma, S. (1996). Characterization of a New Isoform of the NFAT (Nuclear Factor of Activated T Cells) Gene Family Member NFATc. J. Biol. Chem. 271: 20914-20921 [Abstract] [Full Text]  
• Sambasivarao, D., Paetkau, V. (1996). Interactions of a Transcriptional Activator in the env Gene of the Mouse Mammary Tumor Virus with Activation-dependent, T Cell-specific Transacting Factors. J. Biol. Chem. 271: 8942-8950 [Abstract] [Full Text]  
• Ghosh, P., Sica, A., Cippitelli, M., Subleski, J., Lahesmaa, R., Young, H. A., Rice, N. R. (1996). Activation of Nuclear Factor of Activated T Cells in a Cyclosporin A-resistant Pathway. J. Biol. Chem. 271: 7700-7704 [Abstract] [Full Text]  
• Hughes, C. C. W., Pober, J. S. (1996). Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells. J. Biol. Chem. 271: 5369-5377 [Abstract] [Full Text]  
• Tsytsykova, A. V., Tsitsikov, E. N., Geha, R. S. (1996). The CD40L Promoter Contains Nuclear Factor of Activated T Cells-binding Motifs Which Require AP-1 Binding for Activation of Transcription. J. Biol. Chem. 271: 3763-3770 [Abstract] [Full Text]  
• Skerka, C., Decker, E. L., Zipfel, P. F. (1995). A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1. J. Biol. Chem. 270: 22500-22506 [Abstract] [Full Text]  
• Park, J., Yaseen, N. R., Hogan, P. G., Rao, A., Sharma, S. (1995). Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells. J. Biol. Chem. 270: 20653-20659 [Abstract] [Full Text]  
• Ho, S. N., Thomas, D. J., Timmerman, L. A., Li, X., Francke, U., Crabtree, G. R. (1995). NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity. J. Biol. Chem. 270: 19898-19907 [Abstract] [Full Text]  
• Spencer, D., Wandless, T., Schreiber, S., Crabtree, G. (1993). Controlling signal transduction with synthetic ligands. Science 262: 1019-1024 [Abstract]  
• Ullman, K S, Northrop, J P, Admon, A, Crabtree, G R (1993). Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes.. Genes Dev. 7: 188-196 [Abstract]  
• Kang, S.-M., Beverly, B., Tran, A.-C., Brorson, K., Schwartz, R. H., Lenardot, M. J. (1992). Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy. Science 257: 1134-1138 [Abstract]  
• Kang, S., Tran, A., Grilli, M, Lenardo, M. (1992). NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes. Science 256: 1452-1456 [Abstract]