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Mol Cell Biol. 1988 May; 8(5): 1863-1867

A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection.

D M Durnam, J C Menninger, S H Chandler, P P Smith and J K McDougall

Program in Experimental Pathology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

ABSTRACT

Using in situ hybridization, we found that the U2 small nuclear RNA gene cluster mapped very close to and was frequently disrupted by the gaps and breaks induced specifically in the human 17q21-q22 region by highly oncogenic adenovirus type 12 (Ad12). Restriction mapping revealed no structural alterations in the U2 gene locus as a result of Ad12 infection. Likewise, no Ad12-induced alterations in U2 RNA levels were detected. We estimate that the maximum size of the region specifically disrupted by this virus was less than 350 to 700 kilobases. A comparison of these data with similar data regarding biochemically induced fragile sites was made.

Mol Cell Biol. 1988 May; 8(5): 1863-1867




This article has been cited by other articles:

  • Li, Z., Yu, A., Weiner, A. M. (1998). Adenovirus Type 12-Induced Fragility of the Human RNU2 Locus Requires p53 Function. J. Virol. 72: 4183-4191 [Abstract] [Full Text]  
  • Li, Z., Bailey, A. D., Buchowski, J., Weiner, A. M. (1998). A Tandem Array of Minimal U1 Small Nuclear RNA Genes Is Sufficient To Generate a New Adenovirus Type 12Inducible Chromosome Fragile Site. J. Virol. 72: 4205-4211 [Abstract] [Full Text]  
  • Palin, A., Critcher, R, Fitzgerald, D., Anderson, J., Farr, C. (1998). Direct cloning and analysis of DNA sequences from a region of the Chinese hamster genome associated with aphidicolin-sensitive fragility. J. Cell Sci. 111: 1623-1634 [Abstract]  


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