This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maru, Y Articles by Takaku, F Search for Related Content PubMed PubMed Citation Articles by Maru, Y Articles by Takaku, F

 Previous Article  |  Next Article 

Mol Cell Biol. 1988 September; 8(9): 3770-3776

Evolution, expression, and chromosomal location of a novel receptor tyrosine kinase gene, eph.

Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.

ABSTRACT

Partial sequence analysis of the genomic eph locus revealed that the splicing points of kinase domain-encoding exons were completely distinct from those of the other protein tyrosine kinase members reported, suggesting that this is the earliest evolutionary split within this family. In Northern (RNA) blot analysis, the eph gene was expressed in liver, lung, kidney, and testis of rat, and screening of 25 human cancers of various cell types showed preferential expression in cells of epithelial origin. Overexpression of eph mRNA was found in a hepatoma and a lung cancer without gene amplification. Comparison of cDNA sequences derived from a normal liver and a hepatoma that overproduces eph mRNA demonstrated that two of them were completely identical throughout the transmembrane to the carboxy-terminal portions. Southern blot analysis of DNAs from human-mouse hybrid clones with an eph probe showed that this gene was present on human chromosome 7.

This article has been cited by other articles:

• Ogawa, K., Wada, H., Okada, N., Harada, I., Nakajima, T., Pasquale, E. B., Tsuyama, S. (2006). EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases. J. Cell Sci. 119: 559-570 [Abstract] [Full Text]  
• Iida, H, Honda, M, Kawai, H F, Yamashita, T, Shirota, Y, Wang, B-C, Miao, H, Kaneko, S (2005). Ephrin-A1 expression contributes to the malignant characteristics of {alpha}-fetoprotein producing hepatocellular carcinoma. Gut 54: 843-851 [Abstract] [Full Text]  
• Lin, H.-S., Berry, G. J., Fee, W. E. Jr, Terris, D. J., Sun, Z. (2004). Identification of Tyrosine Kinases Overexpressed in Head and Neck Cancer. Arch Otolaryngol Head Neck Surg 130: 311-316 [Abstract] [Full Text]  
• Chiari, R., Hames, G., Stroobant, V., Texier, C., Maillère, B., Boon, T., Coulie, P. G. (2000). Identification of a Tumor-specific Shared Antigen Derived From an Eph Receptor and Presented to CD4 T Cells on HLA Class II Molecules. Cancer Res. 60: 4855-4863 [Abstract] [Full Text]  
• Davis, S, Gale, N., Aldrich, T., Maisonpierre, P., Lhotak, V, Pawson, T, Goldfarb, M, Yancopoulos, G. (1994). Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266: 816-819 [Abstract]