This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Spanopoulou, E Articles by Grosveld, F Search for Related Content PubMed PubMed Citation Articles by Spanopoulou, E Articles by Grosveld, F

 Previous Article  |  Next Article 

Mol Cell Biol. 1988 September; 8(9): 3847-3856

Transcriptional unit of the murine Thy-1 gene: different distribution of transcription initiation sites in brain.

E Spanopoulou, V Giguere and F Grosveld

Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, United Kingdom.

ABSTRACT

Structural analysis of the mouse Thy-1.2 gene has shown that the major promoter of the gene is characterized by a tissue-specific DNase I-hypersensitive site and is located within a methylation-free island. The gene is regulated at the transcriptional level, and steady-state mRNA analysis reveals that the previously reported exon Ib contributes at most 5% of the total mRNA. The major promoter uses several transcription initiation sites within a region of 100 base pairs. The frequency of usage of these sites in brain is markedly different from that in other tissues.

---

Mol Cell Biol. 1988 September; 8(9): 3847-3856

This article has been cited by other articles:

• Sanders, Y. Y., Pardo, A., Selman, M., Nuovo, G. J., Tollefsbol, T. O., Siegal, G. P., Hagood, J. S. (2008). Thy-1 Promoter Hypermethylation: A Novel Epigenetic Pathogenic Mechanism in Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Bio. 39: 610-618 [Abstract] [Full Text]  
• Miles, C, Sanchez, M., Sinclair, A, Dzierzak, E (1997). Expression of the Ly-6E.1 (Sca-1) transgene in adult hematopoietic stem cells and the developing mouse embryo. Development 124: 537-547 [Abstract]  
• Corcoran, L M, Karvelas, M, Nossal, G J, Ye, Z S, Jacks, T, Baltimore, D (1993). Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.. Genes Dev. 7: 570-582 [Abstract]