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Mol Cell Biol. 1988 September; 8(9): 3938-3942

Expression of the c-myb and c-myc genes is regulated independently in differentiating mouse erythroleukemia cells by common processes of premature transcription arrest and increased mRNA turnover.

R J Watson

Imperial Cancer Research Fund Laboratories, St. Bartholomew's Hospital, Bartholomew Close, London, United Kingdom.

ABSTRACT

The mechanisms that modulate c-myb mRNA levels in mouse erythroleukemia cells induced toward erythroid differentiation were compared with those that act on c-myc. Both genes exhibited regulation at the levels of premature transcription arrest and RNA turnover. However, these common processes allowed temporally distinct control of gene expression.


Mol Cell Biol. 1988 September; 8(9): 3938-3942




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