This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Martin-Zanca, D Articles by Barbacid, M Search for Related Content PubMed PubMed Citation Articles by Martin-Zanca, D Articles by Barbacid, M

Molecular and biochemical characterization of the human trk proto-oncogene.

Section of Developmental Oncology, National Cancer Institute Frederick Cancer Research Facility, Maryland 21701.

ABSTRACT

Molecular analysis of the human trk oncogene, a transforming gene isolated from a colon carcinoma biopsy, revealed the existence of a novel member of the tyrosine kinase gene family. This locus, which we now designate the trk proto-oncogene, codes for a protein of 790 amino acid residues that has several features characteristic of cell surface receptors. They include (i) a 32-amino-acid-long putative signal peptide, (ii) an amino-terminal moiety (residues 33 to 407) rich in consensus sites for N-glycosylation, (iii) a transmembrane domain, (iv) a kinase catalytic region highly related to that of other tyrosine kinases, and (v) a very short (15 residue) carboxy-terminal tail. Residues 1 to 392 were absent in the trk oncogene, as they were replaced by tropomyosin sequences. However, no other differences were found between the transforming and nontransforming trk alleles (residues 392 to 790), suggesting that no additional mutations are required to activate the transforming potential of this gene. The human trk proto-oncogene codes for a 140,000-dalton glycoprotein, designated gp140proto-trk. However, its primary translational product is a 110,000-dalton glycoprotein which becomes immediately glycosylated, presumably during its translocation into the endoplasmic reticulum. This molecule, designated gp110proto-trk, is further glycosylated to yield the mature form, gp140proto-trk. Both gp110proto-trk and gp140proto-trk proteins possess in vitro kinase activity specific for tyrosine residues. Finally, iodination of intact NIH 3T3 cells expressing trk proto-oncogene products indicated that only the mature form, gp140proto-trk, cross the plasma membrane, becoming exposed to the outside of the cell. These results indicate that the product of the human trk locus is a novel tyrosine kinase cell surface receptor for an as yet unknown ligand.

This article has been cited by other articles:

• Jin, W., Yun, C., Kim, H.-S., Kim, S.-J. (2007). TrkC Binds to the Bone Morphogenetic Protein Type II Receptor to Suppress Bone Morphogenetic Protein Signaling. Cancer Res. 67: 9869-9877 [Abstract] [Full Text]  
• JOHANSSON, M., NORRGARD, O., FORSGREN, S. (2007). Are Neurotrophins Important in Ulcerative Colitis?. Ann. N. Y. Acad. Sci. 1107: 290-299 [Abstract] [Full Text]  
• Liu, J.-J., Ding, J., Wu, C., Bhagavatula, P., Cui, B., Chu, S., Mobley, W. C., Yang, Y. (2007). Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proc. Natl. Acad. Sci. USA 104: 2223-2228 [Abstract] [Full Text]  
• Tortorolo, L., Langer, A., Polidori, G., Vento, G., Stampachiacchere, B., Aloe, L., Piedimonte, G. (2005). Neurotrophin Overexpression in Lower Airways of Infants with Respiratory Syncytial Virus Infection. Am. J. Respir. Crit. Care Med. 172: 233-237 [Abstract] [Full Text]  
• Parran, D. K., Barker, A., Ehrich, M. (2005). Effects of Thimerosal on NGF Signal Transduction and Cell Death in Neuroblastoma Cells. Toxicol Sci 86: 132-140 [Abstract] [Full Text]  
• Sole, C., Dolcet, X., Segura, M. F., Gutierrez, H., Diaz-Meco, M.-T., Gozzelino, R., Sanchis, D., Bayascas, J. R., Gallego, C., Moscat, J., Davies, A. M., Comella, J. X. (2004). The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-{kappa}B signaling. J. Cell Biol. 167: 479-492 [Abstract] [Full Text]  
• Jimenez, M., de Castro, I. P., Benet, M., Garcia, J. F., Inghirami, G., Pellicer, A. (2004). The Rgr Oncogene Induces Tumorigenesis in Transgenic Mice. Cancer Res. 64: 6041-6049 [Abstract] [Full Text]  
• Jullien, J., Guili, V., Derrington, E. A., Darlix, J.-L., Reichardt, L. F., Rudkin, B. B. (2003). Trafficking of TrkA-Green Fluorescent Protein Chimerae during Nerve Growth Factor-induced Differentiation. J. Biol. Chem. 278: 8706-8716 [Abstract] [Full Text]  
• Jullien, J., Guili, V., Reichardt, L. F., Rudkin, B. B. (2002). Molecular Kinetics of Nerve Growth Factor Receptor Trafficking and Activation. J. Biol. Chem. 277: 38700-38708 [Abstract] [Full Text]  
• Levi-Schaffer, F., Micera, A., Zamir, E., Mechoulam, H., Puxeddu, I., Piliponsky, A. M., Aloe, L., Pe'er, J. (2002). Nerve Growth Factor and Eosinophils in Inflamed Juvenile Conjunctival Nevus. IOVS 43: 1850-1856 [Abstract] [Full Text]  
• Postigo, A., Calella, A. M., Fritzsch, B., Knipper, M., Katz, D., Eilers, A., Schimmang, T., Lewin, G. R., Klein, R., Minichiello, L. (2002). Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes Dev. 16: 633-645 [Abstract] [Full Text]  
• Miranda, C., Di Virgilio, M., Selleri, S., Zanotti, G., Pagliardini, S., Pierotti, M. A., Greco, A. (2002). Novel Pathogenic Mechanisms of Congenital Insensitivity to Pain with Anhidrosis Genetic Disorder Unveiled by Functional Analysis of Neurotrophic Tyrosine Receptor Kinase Type 1/Nerve Growth Factor Receptor Mutations. J. Biol. Chem. 277: 6455-6462 [Abstract] [Full Text]  
• Fiorentini, C., Guerra, N., Facchetti, M., Finardi, A., Tiberio, L., Schiaffonati, L., Spano, P., Missale, C. (2002). Nerve Growth Factor Regulates Dopamine D2 Receptor Expression in Prolactinoma Cell Lines via p75NGFR-Mediated Activation of Nuclear Factor-{kappa}B. Mol. Endocrinol. 16: 353-366 [Abstract] [Full Text]  
• Coppola, V., Kucera, J., Palko, M. E., Martinez-De Velasco, J., Lyons, W. E., Fritzsch, B., Tessarollo, L. (2001). Dissection of NT3 functions in vivo by gene replacement strategy. Development 128: 4315-4327 [Abstract] [Full Text]  
• Plum, L. A., Parada, L. F., Tsoulfas, P., Clagett-Dame, M. (2001). Retinoic Acid Combined with Neurotrophin-3 Enhances the Survival and Neurite Outgrowth of Embryonic Sympathetic Neurons. Exp. Biol. Med. 226: 766-775 [Abstract] [Full Text]  
• Mardy, S., Miura, Y., Endo, F., Matsuda, I., Indo, Y. (2001). Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. Hum Mol Genet 10: 179-188 [Abstract] [Full Text]  
• Davy, D., Campbell, H., Fountain, S, de Jong, D, Crouch, M. (2001). The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases. J. Cell Sci. 114: 549-562 [Abstract]  
• Edsjö, A., Hallberg, B., Fagerström, S., Larsson, C., Axelson, H., Påhlman, S. (2001). Differences in Early and Late Responses between Neurotrophin-stimulated trkA- and trkC-transfected SH-SY5Y Neuroblastoma Cells. Cell Growth Differ. 12: 39-50 [Abstract] [Full Text]  
• Reuther, G. W., Lambert, Q. T., Caligiuri, M. A., Der, C. J. (2000). Identification and Characterization of an Activating TrkA Deletion Mutation in Acute Myeloid Leukemia. Mol. Cell. Biol. 20: 8655-8666 [Abstract] [Full Text]  
• Dissen, G. A., Parrott, J. A., Skinner, M. K., Hill, D. F., Costa, M. E., Ojeda, S. R. (2000). Direct Effects of Nerve Growth Factor on Thecal Cells from Antral Ovarian Follicles. Endocrinology 141: 4736-4750 [Abstract] [Full Text]  
• Arevalo, J. C., Conde, B., Hempstead, B. L., Chao, M. V., Martin-Zanca, D., Perez, P. (2000). TrkA Immunoglobulin-Like Ligand Binding Domains Inhibit Spontaneous Activation of the Receptor. Mol. Cell. Biol. 20: 5908-5916 [Abstract] [Full Text]  
• la Sala, A., Corinti, S., Federici, M., Saragovi, H. U., Girolomoni, G. (2000). Ligand activation of nerve growth factor receptor TrkA protects monocytes from apoptosis. J. Leukoc. Biol. 68: 104-110 [Abstract] [Full Text]  
• Melcher, M., Schmid, M., Aagaard, L., Selenko, P., Laible, G., Jenuwein, T. (2000). Structure-Function Analysis of SUV39H1 Reveals a Dominant Role in Heterochromatin Organization, Chromosome Segregation, and Mitotic Progression. Mol. Cell. Biol. 20: 3728-3741 [Abstract] [Full Text]  
• Gomi, F., Imaizumi, K., Yoneda, T., Taniguchi, M., Mori, Y., Miyoshi, K., Hitomi, J., Fujikado, T., Tano, Y., Tohyama, M. (2000). Molecular Cloning of a Novel Membrane Glycoprotein, Pal, Specifically Expressed in Photoreceptor Cells of the Retina and Containing Leucine-Rich Repeat. J. Neurosci. 20: 3206-3213 [Abstract] [Full Text]  
• Lambiase, A., Manni, L., Bonini, S., Rama, P., Micera, A., Aloe, L. (2000). Nerve Growth Factor Promotes Corneal Healing: Structural, Biochemical, and Molecular Analyses of Rat and Human Corneas. IOVS 41: 1063-1069 [Abstract] [Full Text]  
• O'Connell, L., Hongo, J.-A., Presta, L. G., Tsoulfas, P. (2000). TrkA Amino Acids Controlling Specificity for Nerve Growth Factor. J. Biol. Chem. 275: 7870-7877 [Abstract] [Full Text]  
• Dissen, G. A., Lara, H. E., Leyton, V., Paredes, A., Hill, D. F., Costa, M. E., Martinez-Serrano, A., Ojeda, S. R. (2000). Intraovarian Excess of Nerve Growth Factor Increases Androgen Secretion and Disrupts Estrous Cyclicity in the Rat. Endocrinology 141: 1073-1082 [Abstract] [Full Text]  
• Cozzolino, M, Giovannone, B, Serafino, A, Knudsen, K, Levi, A, Alema, S, Salvatore, A (2000). Activation of TrkA tyrosine kinase in embryonal carcinoma cells promotes cell compaction, independently of tyrosine phosphorylation of catenins. J. Cell Sci. 113: 1601-1610 [Abstract]  
• Micera, A., Lambiase, A., Rama, P., Aloe, L. (1999). Altered nerve growth factor level in the optic nerve of patients affected by multiple sclerosis. Mult Scler 5: 389-394 [Abstract]  
• Garaci, E., Caroleo, M. C., Aloe, L., Aquaro, S., Piacentini, M., Costa, N., Amendola, A., Micera, A., Calio, R., Perno, C.-F., Levi-Montalcini, R. (1999). Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. Proc. Natl. Acad. Sci. USA 96: 14013-14018 [Abstract] [Full Text]  
• Russo, M.A., Giustizieri, M.L., Favale, A., Fantini, M.C., Campagnolo, L., Konda, D., Germano, F., Farini, D., Manna, C., Siracusa, G. (1999). Spatiotemporal Patterns of Expression of Neurotrophins and Neurotrophin Receptors in Mice Suggest Functional Roles in Testicular and Epididymal Morphogenesis. Biol. Reprod. 61: 1123-1132 [Abstract] [Full Text]  
• Jiang, H., Takeda, K., Lazarovici, P., Katagiri, Y., Yu, Z.-X., Dickens, G., Chabuk, A., Liu, X.-W., Ferrans, V., Guroff, G. (1999). Nerve Growth Factor (NGF)-induced Calcium Influx and Intracellular Calcium Mobilization in 3T3 Cells Expressing NGF Receptors. J. Biol. Chem. 274: 26209-26216 [Abstract] [Full Text]  
• Leoni, C., Menegon, A., Benfenati, F., Toniolo, D., Pennuto, M., Valtorta, F. (1999). Neurite Extension Occurs in the Absence of Regulated Exocytosis in PC12 Subclones. Mol. Biol. Cell 10: 2919-2931 [Abstract] [Full Text]  
• Middlemas, D. S., Kihl, B. K., Zhou, J., Zhu, X. (1999). Brain-derived Neurotrophic Factor Promotes Survival and Chemoprotection of Human Neuroblastoma Cells. J. Biol. Chem. 274: 16451-16460 [Abstract] [Full Text]  
• Yamashita, H., Avraham, S., Jiang, S., Dikic, I., Avraham, H. (1999). The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells. J. Biol. Chem. 274: 15059-15065 [Abstract] [Full Text]  
• Sigala, S., Faraoni, I., Botticini, D., Paez-Pereda, M., Missale, C., Bonmassar, E., Spano, P. (1999). Suppression of Telomerase, Reexpression of KAI1, and Abrogation of Tumorigenicity by Nerve Growth Factor in Prostate Cancer Cell Lines. Clin. Cancer Res. 5: 1211-1218 [Abstract] [Full Text]  
• McGregor, L. M., McCune, B. K., Graff, J. R., McDowell, P. R., Romans, K. E., Yancopoulos, G. D., Ball, D. W., Baylin, S. B., Nelkin, B. D. (1999). Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression. Proc. Natl. Acad. Sci. USA 96: 4540-4545 [Abstract] [Full Text]  
• Dragoni, I., Mariotti, M., Consalez, G. G., Soria, M. R., Maier, J. A. M. (1998). EDF-1, a Novel Gene Product Down-regulated in Human Endothelial Cell Differentiation. J. Biol. Chem. 273: 31119-31124 [Abstract] [Full Text]  
• Hallbook, F., Lundin, L.-G., Kullander, K. (1998). Lampetra fluviatilis Neurotrophin Homolog, Descendant of a Neurotrophin Ancestor, Discloses the Early Molecular Evolution of Neurotrophins in the Vertebrate Subphylum. J. Neurosci. 18: 8700-8711 [Abstract] [Full Text]  
• Ozawa, K., Suzuki, S., Asada, M., Tomooka, Y., Li, A.-J., Yoneda, A., Komi, A., Imamura, T. (1998). An Alternatively Spliced Fibroblast Growth Factor (FGF)-5 mRNA Is Abundant in Brain and Translates into a Partial Agonist/Antagonist for FGF-5 Neurotrophic Activity. J. Biol. Chem. 273: 29262-29271 [Abstract] [Full Text]  
• Becker, E., Soler, R. M., Yuste, V. J., Gine, E., Sanz-Rodriguez, C., Egea, J., Martin-Zanca, D., Comella, J. X. (1998). Development of Survival Responsiveness to Brain-Derived Neurotrophic Factor, Neurotrophin 3 and Neurotrophin 4/5, But Not to Nerve Growth Factor, in Cultured Motoneurons from Chick Embryo Spinal Cord. J. Neurosci. 18: 7903-7911 [Abstract] [Full Text]  
• Zapf-Colby, A., Olefsky, J. M. (1998). Nerve Growth Factor Processing and Trafficking Events Following TrkA-Mediated Endocytosis. Endocrinology 139: 3232-3240 [Abstract] [Full Text]  
• Yoon, S. O., Casaccia-Bonnefil, P., Carter, B., Chao, M. V. (1998). Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival. J. Neurosci. 18: 3273-3281 [Abstract] [Full Text]  
• TAKAHASHI, K., OKAMURA, Y. (1998). Ion Channels and Early Development of Neural Cells. Physiol. Rev. 78: 307-337 [Abstract] [Full Text]  
• Nakamura, T., Muraoka, S., Sanokawa, R., Mori, N. (1998). N-Shc and Sck, Two Neuronally Expressed Shc Adapter Homologs. THEIR DIFFERENTIAL REGIONAL EXPRESSION IN THE BRAIN AND ROLES IN NEUROTROPHIN AND Src SIGNALING. J. Biol. Chem. 273: 6960-6967 [Abstract] [Full Text]  
• Urfer, R., Tsoulfas, P., O'Connell, L., Hongo, J.-A., Zhao, W., Presta, L. G. (1998). High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors. J. Biol. Chem. 273: 5829-5840 [Abstract] [Full Text]  
• Chang, B. B., Persengiev, S. P., de Diego, J. G., Sacristan, M. P., Zanca, D. M., Kilpatrick, D. L. (1998). Proximal Promoter Sequences Mediate Cell-specific and Elevated Expression of the Favorable Prognosis Marker TrkA in Human Neuroblastoma Cells. J. Biol. Chem. 273: 39-44 [Abstract] [Full Text]  
• McMahon, G. A., Garfinkel, S., Prudovsky, I., Hu, X., Maciag, T. (1997). Intracellular Precursor Interleukin (IL)-1alpha , but Not Mature IL-1alpha , Is Able to Regulate Human Endothelial Cell Migration in Vitro. J. Biol. Chem. 272: 28202-28205 [Abstract] [Full Text]  
• Shenkman, M., Ayalon, M., Lederkremer, G. Z. (1997). Endoplasmic reticulum quality control of asialoglycoprotein receptor H2a involves a determinant for retention and not retrieval. Proc. Natl. Acad. Sci. USA 94: 11363-11368 [Abstract] [Full Text]  
• Haniu, M., Montestruque, S., Bures, E. J., Talvenheimo, J., Toso, R., Lewis-Sandy, S., Welcher, A. A., Rohde, M. F. (1997). Interactions between Brain-derived Neurotrophic Factor and the TRKB Receptor. IDENTIFICATION OF TWO LIGAND BINDING DOMAINS IN SOLUBLE TRKB BY AFFINITY SEPARATION AND CHEMICAL CROSS-LINKING. J. Biol. Chem. 272: 25296-25303 [Abstract] [Full Text]  
• Yoon, S. O., Soltoff, S. P., Chao, M. V. (1997). A Dominant Role of the Juxtamembrane Region of the TrkA Nerve Growth Factor Receptor during Neuronal Cell Differentiation. J. Biol. Chem. 272: 23231-23238 [Abstract] [Full Text]  
• Grimes, M. L., Beattie, E., Mobley, W. C. (1997). A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc. Natl. Acad. Sci. USA 94: 9909-9914 [Abstract] [Full Text]  
• Tam, S.-Y., Tsai, M., Yamaguchi, M., Yano, K., Butterfield, J. H., Galli, S. J. (1997). Expression of Functional TrkA Receptor Tyrosine Kinase in the HMC-1 Human Mast Cell Line and in Human Mast Cells. Blood 90: 1807-1820 [Abstract] [Full Text]  
• Oishi, I., Sugiyama, S., Liu, Z.-J., Yamamura, H., Nishida, Y., Minami, Y. (1997). A Novel Drosophila Receptor Tyrosine Kinase Expressed Specifically in the Nervous System. UNIQUE STRUCTURAL FEATURES AND IMPLICATION IN DEVELOPMENTAL SIGNALING. J. Biol. Chem. 272: 11916-11923 [Abstract] [Full Text]  
• Cunningham, M. E., Stephens, R. M., Kaplan, D. R., Greene, L. A. (1997). Autophosphorylation of Activation Loop Tyrosines Regulates Signaling by the TRK Nerve Growth Factor Receptor. J. Biol. Chem. 272: 10957-10967 [Abstract] [Full Text]  
• Ihara, Y., Sakamoto, Y., Mihara, M., Shimizu, K., Taniguchi, N. (1997). Overexpression of N-Acetylglucosaminyltransferase III Disrupts the Tyrosine Phosphorylation of Trk with Resultant Signaling Dysfunction in PC12 Cells Treated with Nerve Growth Factor. J. Biol. Chem. 272: 9629-9634 [Abstract] [Full Text]  
• Ananyeva, N. M., Tjurmin, A. V., Berliner, J. A., Chisolm, G. M., Liau, G., Winkles, J. A., Haudenschild, C. C. (1997). Oxidized LDL Mediates the Release of Fibroblast Growth Factor-1. Arterioscler. Thromb. Vasc. Bio. 17: 445-453 [Abstract] [Full Text]  
• Shi, J., Friedman, S., Maciag, T. (1997). A Carboxyl-terminal Domain in Fibroblast Growth Factor (FGF)-2 Inhibits FGF-1 Release in Response to Heat Shock in Vitro. J. Biol. Chem. 272: 1142-1147 [Abstract] [Full Text]  
• Grimes, M. L., Zhou, J., Beattie, E. C., Yuen, E. C., Hall, D. E., Valletta, J. S., Topp, K. S., LaVail, J. H., Bunnett, N. W., Mobley, W. C. (1996). Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes. J. Neurosci. 16: 7950-7964 [Abstract] [Full Text]  
• Apperson, M. L., Moon, I. S., Kennedy, M. B. (1996). Characterization of Densin-180, a New Brain-Specific Synaptic Protein of the O-Sialoglycoprotein Family. J. Neurosci. 16: 6839-6852 [Abstract] [Full Text]  
• Suzuki, Y., Sato, N., Tohyama, M., Wanaka, A., Takagi, T. (1996). cDNA Cloning of a Novel Membrane Glycoprotein That Is Expressed Specifically in Glial Cells in the Mouse Brain. LIG-1, A PROTEIN WITH LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS. J. Biol. Chem. 271: 22522-22527 [Abstract] [Full Text]  
• Segal, R. A., Bhattacharyya, A., Rua, L. A., Alberta, J. A., Stephens, R. M., Kaplan, D. R., Stiles, C. D. (1996). Differential Utilization of Trk Autophosphorylation Sites. J. Biol. Chem. 271: 20175-20181 [Abstract] [Full Text]  
• Ponzetto, C., Zhen, Z., Audero, E., Maina, F., Bardelli, A., Basile, M. L., Giordano, S., Narsimhan, R., Comoglio, P. (1996). Specific Uncoupling of GRB2 from the Met Receptor. DIFFERENTIAL EFFECTS ON TRANSFORMATION AND MOTILITY. J. Biol. Chem. 271: 14119-14123 [Abstract] [Full Text]  
• Prudovsky, I. A., Savion, N., LaVallee, T. M., Maciag, T. (1996). The Nuclear Trafficking of Extracellular Fibroblast Growth Factor (FGF)-1 Correlates with the Perinuclear Association of the FGF Receptor-1alpha Isoforms but Not the FGF Receptor-1beta Isoforms. J. Biol. Chem. 271: 14198-14205 [Abstract] [Full Text]  
• De Bernardi, M. A., Rabin, S. J., Colangelo, A. M., Brooker, G., Mocchetti, I. (1996). trkA Mediates the Nerve Growth Factor-induced Intracellular Calcium Accumulation. J. Biol. Chem. 271: 6092-6098 [Abstract] [Full Text]  
• Tarantini, F., Gamble, S., Jackson, A., Maciag, T. (1995). The Cysteine Residue Responsible for the Release of Fibroblast Growth Factor-1 Resides in a Domain Independent of the Domain for Phosphatidylserine Binding. J. Biol. Chem. 270: 29039-29042 [Abstract] [Full Text]  
• Lucarelli, E., Kaplan, D. R., Thiele, C. J. (1995). Selective Regulation of TrkA and TrkB Receptors by Retinoic Acid and Interferon-[IMAGE] in Human Neuroblastoma Cell Lines. J. Biol. Chem. 270: 24725-24731 [Abstract] [Full Text]  
• Opalenik, S. R., Shin, J. T., Wehby, J. N., Mahesh, V. K., Thompson, J. A. (1995). The HIV-1 TAT Protein Induces the Expression and Extracellular Appearance of Acidic Fibroblast Growth Factor. J. Biol. Chem. 270: 17457-17467 [Abstract] [Full Text]  
• Russell, D. S. (1995). Neurotrophins: New Players, Clinical Uses?. Neuroscientist 1: 119-122 [Abstract]  
• Koh, J., Gwag, B., Lobner, D, Choi, D. (1995). Potentiated necrosis of cultured cortical neurons by neurotrophins. Science 268: 573-575 [Abstract]  
• Heinrich, J. N., Bravo, R. (1995). The Orphan Mouse Receptor Interleukin (IL)-8Rbeta Binds N51. J. Biol. Chem. 270: 4987-4989 [Abstract] [Full Text]  
• Ruan, Y., Chen, C., Cao, Y., Garofalo, R. S. (1995). The Drosophila Insulin Receptor Contains a Novel Carboxyl-terminal Extension Likely to Play an Important Role in Signal Transduction. J. Biol. Chem. 270: 4236-4243 [Abstract] [Full Text]  
• Ferrari, G., Anderson, B. L., Stephens, R. M., Kaplan, D. R., Greene, L. A. (1995). Prevention of Apoptotic Neuronal Death by G[IMAGE] Ganglioside. J. Biol. Chem. 270: 3074-3080 [Abstract] [Full Text]  
• Jackson, A., Tarantini, F., Gamble, S., Friedman, S., Maciag, T. (1995). The Release of Fibroblast Growth Factor-1 from NIH 3T3 Cells in Response to Temperature Involves the Function of Cysteine Residues. J. Biol. Chem. 270: 33-36 [Abstract] [Full Text]  
• Russell, D. S. (1995). Neurotrophins: Mechanisms of Action. Neuroscientist 1: 3-6 [Abstract]  
• Bahramian, M B, Zarbl, H (1994). Direct gene quantitation by PCR reveals differential accumulation of ectopic enzyme in rat-1 cells, v-fos transformants, and revertants.. Genome Res. 4: 145-153 [Abstract]  
• Durbeej, M., Soderstrom, S., Ebendal, T., Birchmeier, C., Ekblom, P. (1993). Differential expression of neurotrophin receptors during renal development. Development 119: 977-989 [Abstract]  
• Tessarollo, L, Tsoulfas, P, Martin-Zanca, D, Gilbert, D., Jenkins, N., Copeland, N., Parada, L. (1993). trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development 118: 463-475 [Abstract]  
• Bossy-Wetzel, E, Bravo, R, Hanahan, D (1992). Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development.. Genes Dev. 6: 2340-2351 [Abstract]  
• Kaplan, D., Hempstead, B., Martin-Zanca, D, Chao, M., Parada, L. (1991). The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252: 554-558 [Abstract]  
• Nebreda, A., Martin-Zanca, D, Kaplan, D., Parada, L., Santos, E (1991). Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk proto-oncogene product. Science 252: 558-561 [Abstract]  
• Martin-Zanca, D, Barbacid, M, Parada, L F (1990). Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.. Genes Dev. 4: 683-694 [Abstract]  
• Tarantini, F., Micucci, I., Bellum, S., Landriscina, M., Garfinkel, S., Prudovsky, I., Maciag, T. (2001). The Precursor but Not the Mature Form of IL1alpha Blocks the Release of FGF1 in Response to Heat Shock. J. Biol. Chem. 276: 5147-5151 [Abstract] [Full Text]  
• Peiro, S., Comella, J. X., Enrich, C., Martin-Zanca, D., Rocamora, N. (2000). PC12 Cells Have Caveolae That Contain TrkA. CAVEOLAE-DISRUPTING DRUGS INHIBIT NERVE GROWTH FACTOR-INDUCED, BUT NOT EPIDERMAL GROWTH FACTOR-INDUCED, MAPK PHOSPHORYLATION. J. Biol. Chem. 275: 37846-37852 [Abstract] [Full Text]  
• Micera, A., Vigneti, E., Pickholtz, D., Reich, R., Pappo, O., Bonini, S., Maquart, F. X., Aloe, L., Levi-Schaffer, F. (2001). Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair. Proc. Natl. Acad. Sci. USA 98: 6162-6167 [Abstract] [Full Text]  
• Perini, G., Della-Bianca, V., Politi, V., Della Valle, G., Dal-Pra, I., Rossi, F., Armato, U. (2002). Role of p75 Neurotrophin Receptor in the Neurotoxicity by {beta}-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines. J. Exp. Med. 195: 907-918 [Abstract] [Full Text]