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Mol Cell Biol. 1989 January; 9(1): 303-311

Anatomy of a new B-cell-specific enhancer.

W Koch, C Benoist and D Mathis

Laboratoire de Génétique Moléculaire des Eucaryotes, Centre National de la Recherche Scientifique, Strasbourg, France.

ABSTRACT

The major histocompatibility complex class II molecules, like the immunoglobulins, are prominent B-lymphocyte markers. Herein, we describe a B-cell-specific enhancer associated with the murine class II gene, Ek alpha. This enhancer has a complex anatomy that suggests interactions between remotely spaced elements. Of particular interest is the finding that two CCAAT boxes spaced one kilobase apart are important for enhancer activity. Somewhat surprisingly, the E alpha and immunoglobulin enhancers seem to show little resemblance.

Mol Cell Biol. 1989 January; 9(1): 303-311




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