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Mol Cell Biol. 1989 January; 9(1): 329-331

A synthetic intron in a naturally intronless yeast pre-tRNA is spliced efficiently in vivo.

M Winey, I Edelman and M R Culbertson

Laboratory of Genetics, University of Wisconsin, Madison 53706.

ABSTRACT

Saccharomyces cerevisiae glutamine tRNA(CAG) is encoded by an intronless, single-copy gene, SUP60. We have imposed a requirement for splicing in the biosynthesis of this tRNA by inserting a synthetic intron in the SUP60 gene. Genetic analysis demonstrated that the interrupted gene produces a functional, mature tRNA product in vivo.

Mol Cell Biol. 1989 January; 9(1): 329-331






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