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Mol Cell Biol. 1989 February; 9(2): 355-364

A negative regulatory element with properties similar to those of enhancers is contained within an Alu sequence.

Jackson Laboratory, Bar Harbor, Maine 04609.

ABSTRACT

A negative regulatory element has been found within a member of the African green monkey Alu family of interspersed repeated sequences. This "reducer" element decreased transcription in both directions from a cellular simian virus 40-like bidirectional promoter independently of both orientation and position. The reducer was not promoter specific since it also decreased expression from the simian virus 40 early and human beta-globin promoters. In addition, the reducer decreased transcription from a polymerase III promoter. The reducer was contained in 38 base pairs of an Alu family member and interacted specifically with a monkey cell nuclear protein.

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