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Mol Cell Biol. 1989 March; 9(3): 1342-1345

Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene.

H Lubon, P Ghazal, L Hennighausen, C Reynolds-Kohler, C Lockshin and J Nelson

Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892.

ABSTRACT

In this paper we demonstrate that modulator sequences upstream of the enhancer of the major immediate-early promoter of human cytomegalovirus exert a differential effect on the level of transcription in a variety of cells and that this region has the capacity to interact with specific nuclear protein. Depending on the cell type, these modulator sequences increased or decreased transcriptional activation from the IE1 gene promoter-enhancer. The cell lines identified in this report should be useful to study the molecular mechanism of cell-specific transcriptional repression and activation exerted by the major immediate-early promoter upstream region.

Mol Cell Biol. 1989 March; 9(3): 1342-1345




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