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Mol Cell Biol. 1989 March; 9(3): 1357-1361

Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.

E Schuuring, L van Deemter, H Roelink and R Nusse

Division of Molecular Biology, Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Amsterdam.

ABSTRACT

In mouse embryos, the int-1 proto-oncogene is transiently expressed in areas of the developing neural system. Retinoic acid-treated P19 embryonal carcinoma cells have often been used as an in vitro model for the molecular basis of neural development. We shown here that int-1 is transiently expressed in differentiated P19 cells. The time course and retinoic acid dose dependence of int-1 expression suggest that the gene is specifically expressed during early neural differentiation. P19 cells may be a useful model to assist in the study, at the cellular level, of the role of int-1 in neural development.

Mol Cell Biol. 1989 March; 9(3): 1357-1361




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  • Echelard, Y, Vassileva, G, McMahon, A. (1994). Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development 120: 2213-2224 [Abstract]  
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