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Mol Cell Biol. 1989 March; 9(3): 1368-1370

Acquisition and processing of a conditional dicentric chromosome in Saccharomyces cerevisiae.

A Hill and K Bloom

Department of Biology, University of North Carolina, Chapel Hill 27599-3280.

ABSTRACT

The introduction of a conditional centromere into chromosome III of Saccharomyces cerevisiae provided an opportunity to evaluate phenotypic and karyotypic consequences in cells harboring dicentric chromosomes upon entry into mitosis. A mitotic pause ensued, and monocentric derivatives of chromosome III were generated at a high frequency.

Mol Cell Biol. 1989 March; 9(3): 1368-1370




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