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Isolation and sequence analysis of a novel human tyrosine kinase gene.

Division of Medical Genetics, Childrens Hospital of Los Angeles, California 90027.

ABSTRACT

Using v-abl probes, we have identified and cloned a novel fes/fps-homologous human cDNA, which we have designated FER (pronounced "fair"). This apparently full-length cDNA of 3.0 kilobases has an open reading frame of 2,466 base pairs and the capacity to encode a protein of 94,000 molecular weight. The cDNA contains regions homologous to the highly conserved tyrosine protein kinase domain of other oncogenes and growth factor receptors but lacks a clear transmembrane region, indicating that it encodes a tyrosine kinase of the nonreceptor type. The deduced amino acid sequence of FER resembles that of c-fes/fps. Our data indicate that the protein product of FER, p94FER, corresponds to a previously reported cellular phosphoprotein, NCP94, detected with a v-fps-specific antipeptide antiserum.

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• Craig, A. W. B., Zirngibl, R., Williams, K., Cole, L.-A., Greer, P. A. (2001). Mice Devoid of Fer Protein-Tyrosine Kinase Activity Are Viable and Fertile but Display Reduced Cortactin Phosphorylation. Mol. Cell. Biol. 21: 603-613 [Abstract] [Full Text]  
• Senis, Y., Zirngibl, R., McVeigh, J., Haman, A., Hoang, T., Greer, P. A. (1999). Targeted Disruption of the Murine fps/fes Proto-Oncogene Reveals that Fps/Fes Kinase Activity Is Dispensable for Hematopoiesis. Mol. Cell. Biol. 19: 7436-7446 [Abstract] [Full Text]  
• Craig, A. W. B., Zirngibl, R., Greer, P. (1999). Disruption of Coiled-coil Domains in Fer Protein-tyrosine Kinase Abolishes Trimerization but Not Kinase Activation. J. Biol. Chem. 274: 19934-19942 [Abstract] [Full Text]  
• Ben-Dor, I., Bern, O., Tennenbaum, T. (1999). Cell Cycle-dependent Nuclear Accumulation of the p94fer Tyrosine Kinase Is Regulated by Its NH2 Terminus and Is Affected by Kinase Domain Integrity and ATP Binding. Cell Growth Differ. 10: 113-129 [Abstract] [Full Text]  
• Rosato, R., Veltmaat, J. M., Groffen, J., Heisterkamp, N. (1998). Involvement of the Tyrosine Kinase Fer in Cell Adhesion. Mol. Cell. Biol. 18: 5762-5770 [Abstract] [Full Text]  
• Kim, L., Wong, T. W. (1998). Growth Factor-dependent Phosphorylation of the Actin-binding Protein Cortactin Is Mediated by the Cytoplasmic Tyrosine Kinase FER. J. Biol. Chem. 273: 23542-23548 [Abstract] [Full Text]  
• de Jong, R., van Wijk, A., Haataja, L., Heisterkamp, N., Groffen, J. (1997). BCR/ABL-induced Leukemogenesis Causes Phosphorylation of Hef1 and Its Association with Crkl. J. Biol. Chem. 272: 32649-32655 [Abstract] [Full Text]  
• Yates, K., Gasson, J. (1996). Role of c-Fes in normal and neoplastic hematopoiesis. Stem Cells 14: 117-123 [Abstract]  
• Penhallow, R. C., Class, K., Sonoda, H., Bolen, J. B., Rowley, R. B. (1995). Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell Fc[IMAGE]RI Engagement. J. Biol. Chem. 270: 23362-23365 [Abstract] [Full Text]  
• Linnekin, D., Mou, S. M., Greer, P., Longo, D. L., Ferris, D. K. (1995). Phosphorylation of a Fes-related Protein in Response to Granulocyte-Macrophage Colony Stimulating Factor. J. Biol. Chem. 270: 4950-4954 [Abstract] [Full Text]  
• Kinzler, K., Nilbert, M., Su, L., Vogelstein, B, Bryan, T., Levy, D., Smith, K., Preisinger, A., Hedge, P, McKechnie, D, et, al. (1991). Identification of FAP locus genes from chromosome 5q21. Science 253: 661-665 [Abstract]  
• Nishisho, I, Nakamura, Y, Miyoshi, Y, Miki, Y, Ando, H, Horii, A, Koyama, K, Utsunomiya, J, Baba, S, Hedge, P (1991). Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253: 665-669 [Abstract]  
• Koch, C., Anderson, D, Moran, M., Ellis, C, Pawson, T (1991). SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252: 668-674 [Abstract]  
• Priel-Halachmi, S., Ben-Dor, I., Shpungin, S., Tennenbaum, T., Molavani, H., Bachrach, M., Salzberg, S., Nir, U. (2000). FER Kinase Activation of Stat3 Is Determined by the N-terminal Sequence. J. Biol. Chem. 275: 28902-28910 [Abstract] [Full Text]