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Mol Cell Biol. 1989 May; 9(5): 2251-2253

The alternatively spliced exon of the platelet-derived growth factor A chain encodes a nuclear targeting signal.

D W Maher, B A Lee and D J Donoghue

Department of Chemistry, University of California--San Diego, La Jolla 92093.

ABSTRACT

We have previously shown that the SIS/platelet-derived growth factor B chain contains a nuclear targeting signal near its C terminus. Here we show that the platelet-derived growth factor A chain also contains a nuclear targeting signal encoded by an exon which is subject to alternative splicing. This sequence is capable of targeting a nonsecreted form of the A chain to the nucleus and can also target the cytoplasmic proteins dihydrofolate reductase, chloramphenicol acetyltransferase, and pyruvate kinase to the nucleus.

Mol Cell Biol. 1989 May; 9(5): 2251-2253




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