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Mol Cell Biol. 1989 June; 9(6): 2657-2664

Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events.

Sloan-Kettering Institute for Cancer Research, New York, New York 10021.

ABSTRACT

We have examined avian leukosis virus-induced B-cell lymphomas for multiple, stage-specific oncogene activations. Three targets for viral integration were identified: c-myb, c-myc, and a newly identified locus termed c-bic. The c-myb and c-myc genes were associated with different lymphoma phenotypes. The c-bic locus was a target for integration in one class of lymphomas, usually in conjunction with c-myc activation. The data indicate that c-myc and c-bic may act synergistically during lymphomagenesis and that c-bic is involved in late stages of tumor progression.

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