This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gabuzda, D H Articles by Clements, J E Search for Related Content PubMed PubMed Citation Articles by Gabuzda, D H Articles by Clements, J E

 Previous Article  |  Next Article 

Mol Cell Biol. 1989 June; 9(6): 2728-2733

Regulation of the visna virus long terminal repeat in macrophages involves cellular factors that bind sequences containing AP-1 sites.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

ABSTRACT

Visna virus gene expression is highly restricted in monocytes but is induced by monocyte-macrophage differentiation in vivo. Deletion and linker-scanning mutants, gel shift assays, and DNase I footprinting were used to identify sequences in the visna virus long terminal repeat involved in the developmental regulation of gene expression in the U937 monocytic cell line. We found that an AP-1 and an AP-4 binding site were critical for basal activity and that the AP-1 site was required for phorbol ester-inducible gene expression. These results suggest that cellular factors that interact with AP-1 sites are involved in the developmental regulation of visna virus gene expression in macrophages.

This article has been cited by other articles:

• Arfi, V., Riviere, L., Jarrosson-Wuilleme, L., Goujon, C., Rigal, D., Darlix, J.-L., Cimarelli, A. (2008). Characterization of the Early Steps of Infection of Primary Blood Monocytes by Human Immunodeficiency Virus Type 1. J. Virol. 82: 6557-6565 [Abstract] [Full Text]  
• Grant, C., Jain, P., Nonnemacher, M., Flaig, K. E., Irish, B., Ahuja, J., Alexaki, A., Alefantis, T., Wigdahl, B. (2006). AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation. J. Leukoc. Biol. 80: 640-650 [Abstract] [Full Text]  
• Barber, S. A., Bruett, L., Douglass, B. R., Herbst, D. S., Zink, M. C., Clements, J. E. (2002). Visna Virus-Induced Activation of MAPK Is Required for Virus Replication and Correlates with Virus-Induced Neuropathology. J. Virol. 76: 817-828 [Abstract] [Full Text]  
• Lyall, J. W., Solanky, N., Tiley, L. S. (2000). Restricted species tropism of maedi-visna virus strain EV-1 is not due to limited receptor distribution. J. Gen. Virol. 81: 2919-2927 [Abstract] [Full Text]  
• Agnarsdóttir, G., Thorsteinsdóttir, H., Óskarsson, T., Matthíasdóttir, S., St. Haflidadóttir, B., Andrésson, O. S., Andrésdóttir, V. (2000). The long terminal repeat is a determinant of cell tropism of maedi-visna virus. J. Gen. Virol. 81: 1901-1905 [Abstract] [Full Text]  
• Morse, B. A., Carruth, L. M., Clements, J. E. (1999). Targeting of the Visna Virus Tat Protein to AP-1 Sites: Interactions with the bZIP Domains of Fos and Jun In Vitro and In Vivo. J. Virol. 73: 37-45 [Abstract] [Full Text]  
• Gatignol, A, Buckler-White, A, Berkhout, B, Jeang, K. (1991). Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. Science 251: 1597-1600 [Abstract]