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Mol Cell Biol. 1989 June; 9(6): 2748-2751

Effect of 5-azacytidine on gene expression in marrow stromal cells.

D F Andrews 3rd, J Nemunaitis, C Tompkins and J W Singer

Medical Service, VA Medical Center, Seattle, Washington 98108.

ABSTRACT

When exposed to 5-azacytidine, marrow stromal cells from active long-term marrow cultures and cell lines derived from simian virus 40-transformed stromal cells rapidly upregulated c-abl and interleukin-6 transcripts while downregulating the expression of collagen I, a major matrix protein. Similar effects occurred with interleukin-1 alpha and tumor necrosis factor alpha, although the time course was considerably prolonged.

Mol Cell Biol. 1989 June; 9(6): 2748-2751






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