Molecular and Cellular Biology, April 2003, p. 3030, Vol. 23, No. 8
0270-7306/03/$08.00+0 DOI: 10.1128/MCB.23.8.3030.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
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Laboratory of Cell Biology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York
Volume 20, no. 9, p. 3097-3101, 2002. Recently, we discovered that the spectrophotometric assay determinations for neutrophil-specific myeloperoxidase were wrong. We reported that in lipopolysaccharide inflammation in Dfy-/- mice there was less enzymatic activity and, therefore, less neutrophil recruitment in the intestine and lungs than in wild-type animals. Now we find out that there is more neutrophil migration in mutants versus wild-type animals. These results are consistent with those published by T. C. Dawson et al. (Blood 96:1681-1684, 2000) and support the idea that mouse Duffy glycoprotein as a chemokine binding protein quenches chemokine activities and down regulates neutrophil trafficking.
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