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Author's Correction for Phan et al., Mol. Cell. Biol. 23 (13) 4573-4585.
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Molecular and Cellular Biology, July 2005, p. 5787, Vol. 25, No. 13
0270-7306/05/$08.00+0     doi:10.1128/MCB.25.13.5787.2005

ERRATUM

Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation

Vernon T. Phan, David B. Shultz, Bao-Tran H. Truong, Timothy J. Blake, Anna L. Brown, Thomas J. Gonda, Michelle M. Le Beau, and Scott C. Kogan

Department of Laboratory Medicine and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California; Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; and Section of Hematology/Oncology, University of Chicago, Chicago, Illinois

Volume 23, no. 13, p. 4573-4585, 2003. We regret that the construct labeled ßcI374N in Fig. 5 and 8 and in the text has been found to be ßcI374A, a construct that is not constitutively activated. Following the discovery of this unfortunate error, we have transduced PML-RARA transgenic bone marrow with the correct ßcI374N construct. In contrast to what we reported, ßcI374N can, like ßcV449E, cooperate with PML-RARA to induce leukemias with features of acute promyelocytic leukemia. Hence, although we believe that the other results and conclusions of the work are correct (including the central point of the paper, the cooperation of cytokine signaling with PML-RAR{alpha} in blocking differentiation and inducing leukemia), the results that we presented and discussed for ßcI374N (Discussion, paragraph 6) are incorrect. We apologize for any difficulties or confusion that this error may have caused for our colleagues.

Molecular and Cellular Biology, July 2005, p. 5787, Vol. 25, No. 13
0270-7306/05/$08.00+0     doi:10.1128/MCB.25.13.5787.2005





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