Smad4 Dependency Defines Two Classes of Transforming Growth Factor ß (TGF-ß) Target Genes and Distinguishes TGF-ß-Induced Epithelial-Mesenchymal Transition from Its Antiproliferative and Migratory Responses
Mol. Cell. Biol. Levy and Hill
25: 8108
Supplemental material
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Supplemental file 1 -
Supplemental experimental procedures and Fig. S1 (Validation by RNase protection of Smad4 dependency of TGF-[uppercase Greek beta]-induced activation of PAI-1 and of Smad4 independency of TGF-[uppercase Greek beta]-induced activation of CDKN1A [p21], SMAD7, CDKN2B [p15], and c-JUN), S2 (Smad4 is not involved in loss of adherens junctions induced by TGF-[uppercase Greek beta] in HaCaT cells), S3 (Vimentin is still induced by TGF-[uppercase Greek beta] after silencing of SMAD4), and S4 (Some Smad4-independent genes are still induced in Smad4-null tumor cell line BxPC3 but not in MDA-MB468 and SW480)
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