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DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation
Mol. Cell. Biol. Okamoto et al. 25: 9608

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Files in this Data Supplement:

  • Supplemental file 1 - Fig. S1 (Phosphatase treatment abolishes reactivity of anti-P-S367 antibody for Mdmx), S2 (S367 mutations abolish binding between Mdmx and 14-3-3), S3 (S367A mutation renders Mdmx resistant to Mdm2-mediated inhibition in Mdmx/p53-deficient cells), S4 (The S367A and the C463A mutants are resistant to Mdm2-mediated ubiquitination), S5 (A variety of DNA damage treatments induce S367 phosphorylation), S6 (DNA damage augments binding of Mdmx to 14-3-3 in vitro), S7 (DNA damage promotes degradation of endogenous Mdmx), and S8 (Caffeine blocks DNA damage-induced S367 phosphorylation).
    Zipped PowerPoint presentation, 4MB.
  • Supplemental file 2 - Legends for supplemental figures
    MS Word document, 32.5K.




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