
DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation
Mol. Cell. Biol. Okamoto et al.
25: 9608
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- Supplemental file 1
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Fig. S1 (Phosphatase treatment abolishes reactivity of anti-P-S367 antibody for Mdmx), S2 (S367 mutations abolish binding between Mdmx and 14-3-3), S3 (S367A mutation renders Mdmx resistant to Mdm2-mediated inhibition in Mdmx/p53-deficient cells), S4 (The S367A and the C463A mutants are resistant to Mdm2-mediated ubiquitination), S5 (A variety of DNA damage treatments induce S367 phosphorylation), S6 (DNA damage augments binding of Mdmx to 14-3-3 in vitro), S7 (DNA damage promotes degradation of endogenous Mdmx), and S8 (Caffeine blocks DNA damage-induced S367 phosphorylation).
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- Supplemental file 2
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Legends for supplemental figures
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