
Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions
Mol. Cell. Biol. Bartz et al.
26: 9377
Supplemental material
Files in this Data Supplement:
- Supplemental file 1
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Fig. S1 (TP53-mediated G1 arrest in response to doxorubicin) and S2 (Verification of selected BRCA pathway genes as selective cisplatin enhancers)
Zipped PDF document, 31K.
- Supplemental file 2
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Tables S1 (siRNA duplexes used to target genes), S2 (Consensus hits from subgenomic enhancer screens), S3 (Decrease in cisplatin EC50), and S4 (Confirmed cisplatin enhancers are enriched for genes involved in cell checkpoints and DNA damage response)
Zipped Excel document, 16K.
- Supplemental file 3
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Legends to Fig. S1 and S2 and Tables S1 to S4
Zipped PDF document, 6K.