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Figure 5


FIG. 5. Lineage tracing of area III-containing, Pdx1XBCre-mediated recombination throughout the endogenous Pdx1 domain. Whole-mount pictures of X-Gal-stained E10.5 (B) and E11.5 (E) embryos and dissected digestive organs at E10.5 (A), E11.5 (D), E14.5 (F), and P1 (G). (C) Cross-section of X-Gal-stained P1 pancreas labeled with antibodies to glucagon (Gluc; brown). The pictures are representative of expression observed in four of four independent transgenic mice. L, liver; s, stomach; I, rostral duodenal portion of the intestine; b, bile duct; i, pancreatic islet; a, acinus; d, duct; db, dorsal bud; vb, ventral bud. The diagram refers to the transgene used to create the mice analyzed in this figure and the R26R reporter construct for lineage tracing of Cre-expressing cells (not to scale).





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