Files in this Data Supplement:

• Supplemental file 1 - Supplemental figure legends
  MS Word document, 27K.
• Supplemental file 2 - Fig. S2 (RPA interacts with MRN in multiple cell lines)
  Zipped TIF document, 617K.
• Supplemental file 3 - Fig. S3 (Mre11-DD and NAAIRS mutants are localized in the nucleus, but the bright-staining S-phase foci do not colocalize with sites of BrdU incorporation after extraction)
  Zipped TIF document, 73K.
• Supplemental file 4 - Fig. S1 (Interaction of MRN with RPA is not changed after IR)
  Zipped TIF document, 232K.
• Supplemental file 5 - Fig. S4 (Expression of Myc-tagged RPA2, Mre11, Mre11-NAAIRS, and Mre11-DD in T98G cells)
  Zipped TIF document, 57K.
• Supplemental file 6 - Fig. S5 (Alignment of conserved motif mediating protein association in human Mre11, Nbs1, ATRIP, and Ku80)
  Zipped TIF document, 55K.