
Fer-Mediated Cortactin Phosphorylation Is Associated with Efficient Fibroblast Migration and Is Dependent on Reactive Oxygen Species Generation during Integrin-Mediated Cell Adhesion
Mol. Cell. Biol. Sangrar et al.
27: 6140
Supplemental material
Files in this Data Supplement:
- Supplemental file 1
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Legends to Fig. S1 to S6 and Movies S1 to S3
MS Word document, 34K.
- Supplemental file 2
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Fig. S1 (Fer is activated by H2O2 in a variety of cell types)
Zipped TIF document, 642K.
- Supplemental file 3
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Fig. S2 (H2O2 strongly induced Ctn phosphorylation at Y421 and Y466)
Zipped TIF document, 224K.
- Supplemental file 4
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Fig. S3 (Integrin engagement-induced phosphorylation of paxillin and p130Cas in ferDR/DR MEF)
Zipped TIF document, 559K.
- Supplemental file 5
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Fig. S4 (Fer rescue expression levels)
Zipped TIF document, 409K.
- Supplemental file 6
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Fig. S5 (Fer autophosphorylation and Ctn phosphorylation were not stimulated by H2O2 treatment in vitro)
Zipped TIF document, 434K.
- Supplemental file 7
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Fig. S6 (Fn-induced tyrosine phosphorylation of Fer in the presence of NAC, Tiron, and DPI)
Zipped TIF document, 149K.
- Supplemental file 8
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Movie S1 (Migration of a monolayer of wt MEF across a scrape wound)
Zipped QuickTime video, 8MB.
- Supplemental file 9
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Movie S2 (Migration of a monolayer of fer-deficient MEF across a scrape wound)
Zipped QuickTime video, 8.8MB.
- Supplemental file 10
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Movie S3 (Migration of a monolayer of MEF rescued by DsRed-Fer)
Zipped QuickTime video, 10.4MB.