Files in this Data Supplement:

• Supplemental file 1 - Fig. S1 (Lys119 of H2AX is ubiquitinated after induction of DSBs)
  Zipped PDF document, 204K.
• Supplemental file 2 - Fig. S2 (Suppression of DSB-induced acetylation and dynamics of H2AX by siTIP60.2)
  Zipped PDF document, 189K.
• Supplemental file 3 - Fig. S3 (Acetylation-dependent ubiquitination of H2AX occurs immediately after DNA damage in 293T cells)
  Zipped PDF document, 402K.
• Supplemental file 4 - Fig. S4 (Biological consequence of DSB-induced acetylation and ubiquitination of H2AX)
  Zipped PDF document, 253K.
• Supplemental file 5 - Fig. S5 (Specific depletion of UBC13 by siUBC13.2)
  Zipped PDF document, 222K.
• Supplemental file 6 - Fig. S6 (Dynamics of major histones H2B, H3, and H4 after induction of DNA DSBs)
  Zipped PDF document, 233K.
• Supplemental file 7 - Fig. S7 (TIP60 is required for DSB-induced RAD51 focus formation but not for the recruitment of MRE11 to damaged chromatin)
  Zipped PDF document, 640K.
• Supplemental file 8 - Video S1 (Dynamics of H2AX after induction of DSBs by microirradiation)
  MS video, 1.1MB.
• Supplemental file 9 - Supplemental text and legends to Fig. S1 to S7 and Video S1
  Zipped PDF document, 100K.