DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics
Mol. Cell. Biol. Ikura et al.
27: 7028
Supplemental material
Files in this Data Supplement:
Supplemental file 1
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Fig. S1 (Lys119 of H2AX is ubiquitinated after induction of DSBs) Zipped PDF document, 204K.
Supplemental file 2
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Fig. S2 (Suppression of DSB-induced acetylation and dynamics of H2AX by siTIP60.2) Zipped PDF document, 189K.
Supplemental file 3
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Fig. S3 (Acetylation-dependent ubiquitination of H2AX occurs immediately after DNA damage in 293T cells) Zipped PDF document, 402K.
Supplemental file 4
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Fig. S4 (Biological consequence of DSB-induced acetylation and ubiquitination of H2AX) Zipped PDF document, 253K.
Supplemental file 5
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Fig. S5 (Specific depletion of UBC13 by siUBC13.2) Zipped PDF document, 222K.
Supplemental file 6
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Fig. S6 (Dynamics of major histones H2B, H3, and H4 after induction of DNA DSBs) Zipped PDF document, 233K.
Supplemental file 7
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Fig. S7 (TIP60 is required for DSB-induced RAD51 focus formation but not for the recruitment of MRE11 to damaged chromatin) Zipped PDF document, 640K.
Supplemental file 8
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Video S1 (Dynamics of H2AX after induction of DSBs by microirradiation) MS video, 1.1MB.
Supplemental file 9
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Supplemental text and legends to Fig. S1 to S7 and Video S1 Zipped PDF document, 100K.