Files in this Data Supplement:

• Supplemental file 1 - Fig. S1 (Mobilization of cytosolic Ca²⁺ by thrombin is mediated by PAR 1)
  Zipped TIF document, 191K.
• Supplemental file 2 - Fig. S2 (Heterogeneous Ca²⁺ mobilization and mitochondrial Ca²⁺ uptake in response to low thrombin levels in MPMVECs)
  Zipped TIF document, 1.6MB.
• Supplemental file 3 - Fig. S3 (Mitochondrial complex III inhibitor antimycin A leads to mitochondrial O₂.- production)
  Zipped TIF document, 760K.
• Supplemental file 4 - Fig. S4 (MnSOD overexpression in PMVECs)
  Zipped TIF document, 1.1MB.
• Supplemental file 5 - Fig. S5 (O2.--mediated signaling stimulates NF-κB activation in PMVECs)
  Zipped TIF document, 752K.
• Supplemental file 6 - Fig. S6 (Thrombin-mediated Ca²⁺ mobilization is unaltered by MnTBAP)
  Zipped TIF document, 34K.
• Supplemental file 7 - Fig. S7 (TNF-α does not trigger Ca²⁺ mobilization or mROS production)
  Zipped TIF document, 48K.
• Supplemental file 8 - Supplemental text and legends to Fig. S1 to S7
  MS Word document, 33K.