Files in this Data Supplement:

• Supplemental file 1 - Fig. S1 (Dicer^ex5 cell enhanced transcript regulation following miRNA transfection), S2 (miRNAs with seed region identity trigger overlapping gene expression profiles), S3 (miRNA families), S4 (miR-16 cell cycle phenotype is induced in Dicer wild-type cells), S5 (miR-16 down-regulated transcripts regulation by other miR-16 family members), S6 (miR-16 down-regulated transcripts overlap poorly with computationally predicted targets), and S7 (siRNAs to miR-16 down-regulated targets maintain silencing when added in combination) and Tables S1 (Sequences of miRNA and siRNA duplexes), S2 (Expression signatures reported in this study), S3 (Quantitation of flow cytometry phenotypes and mRNA silencing by RNA duplexes), S4 (Consensus miR-16 down-regulated transcripts), S5 (Non-miR-16 targets tested in Fig. 4A), and S6 (Levels of miR-16 down-regulated transcripts and miR-195 in human tumors)
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