Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance
Mol. Cell. Biol. Bayascas et al.
28: 3258
Supplemental material
Files in this Data Supplement:
- Supplemental file 1 -
fig. S1 (PDK1 activity in different tissues of PDK1K465E/K465E mice), S2 (Normal size of heterozygous PDK1K465E/+ mice), S3 (Characterization of glucose homoeostasis in PDK1K465E/K465E female mice), S4 (Blood glucose and plasma insulin levels in old PDK1K465E/K465E mice), S5 (Quantitative analysis of PKB phosphorylation at Thr308 and Ser473 in PDK1K465E/K465E muscle), S6 (Normal activation of RSK in PDK1K465E/K465E ES cells and Immunoblotting of PKC isoforms in PDK1K465E/K465E muscle), S7 (Muscle glucose transport in PDK1K465E/K465E mice), and S8 (Expression of liver gluconeogenic and lipogenic genes in PDK1K465E/K465E mice) .
PDF document, 650K.
- Supplemental file 2
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Supplemental text, legends to Fig. S1 to S8, and Table S1 (Data for the PDK1[K465E] PH domain mutant).
MS Word document, 155K.
