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FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability
Mol. Cell. Biol. Wu et al. 28: 4116

Supplemental material

Files in this Data Supplement:

  • Supplemental file 1 - Supplemental figure legends and references.
    Zipped MS Word document, 8K.
  • Supplemental file 2 - Table S1 (IC50 values for inhibition of FANCJ helicase activity by selected small molecules).
    Zipped MS Word document,3K.
  • Supplemental file 3 - Fig. S1 (SDS-PAGE and Coomassie stain of proteins used).
    Zipped TIF file, 296K.
  • Supplemental file 4 - Fig. S2 (FANCJ efficiently unwinds G4 DNA in a protein concentration-dependent manner).
    Zipped TIF file, 228K.
  • Supplemental file 5 - Fig. S3 ( RECQ1 fails to unwind G4 DNA).
    Zipped TIF file, 326K.
  • Supplemental file 6 - Fig. S4 (G4-interactive molecule telomestatin potently inhibits BLM G4 helicase) .
    Zipped TIF file, 204K.
  • Supplemental file 7 - Fig. S5 (Effects of small molecules NMM and T4 on FANCJ helicase activity).
    Zipped TIF file, 26K.
  • Supplemental file 8 - Fig. S6 (FANCJ depletion cells sensitizes to MMC and TMS).
    Zipped TIF file, 29K.
  • Supplemental file 9 - Fig. S7 (FA-A and FA-D2 mutant cell lines are not sensitive to TMS).
    Zipped TIF file, 20K.
  • Supplemental file 10 - Fig. S8 (Telomestatin induces elevated γ-H2AX foci in FANCJ-depleted HeLa cells).
    Zipped TIF file, 417K.




This Article
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