FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability
Mol. Cell. Biol. Wu et al.
28: 4116
Supplemental material
Files in this Data Supplement:
- Supplemental file 1
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Supplemental figure legends and references.
Zipped MS Word document, 8K.
- Supplemental file 2
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Table S1 (IC50 values for inhibition of FANCJ helicase activity by selected small molecules).
Zipped MS Word document,3K.
- Supplemental file 3
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Fig. S1 (SDS-PAGE and Coomassie stain of proteins used).
Zipped TIF file, 296K.
- Supplemental file 4
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Fig. S2 (FANCJ efficiently unwinds G4 DNA in a protein concentration-dependent manner).
Zipped TIF file, 228K.
- Supplemental file 5
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Fig. S3 ( RECQ1 fails to unwind G4 DNA).
Zipped TIF file, 326K.
- Supplemental file 6
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Fig. S4 (G4-interactive molecule telomestatin potently inhibits BLM G4 helicase) .
Zipped TIF file, 204K.
- Supplemental file 7
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Fig. S5 (Effects of small molecules NMM and T4 on FANCJ helicase activity).
Zipped TIF file, 26K.
- Supplemental file 8
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Fig. S6 (FANCJ depletion cells sensitizes to MMC and TMS).
Zipped TIF file, 29K.
- Supplemental file 9
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Fig. S7 (FA-A and FA-D2 mutant cell lines are not sensitive to TMS).
Zipped TIF file, 20K.
- Supplemental file 10
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Fig. S8 (Telomestatin induces elevated γ-H2AX foci in FANCJ-depleted HeLa cells).
Zipped TIF file, 417K.
