Files in this Data Supplement:

• Supplemental file 1 - Tables S1 and S2 (Peptide sequences and ICAT ratios for all conditioned-medium proteins [S1] and all proteins [S2] identified by ICAT and MD-LC MS/MS analysis), S3 (Technical replicate analysis), S4 (Known substrate analysis), S5 (Effect of MMP-14 on secreted proteins of MDA-MB-231 cells), S6A (Peptide sequences and ICAT ratios for proteins shown in Table S3), S6B (MMPI blocks release or shedding to the conditioned medium), S7 (Membrane accumulation of proteins upon MMPI treatment), and S8 and S9 (Candidate metalloprotease substrates), legends to Fig. S1 to 4, and supplemental text.
  PDF document, 842K.
• Supplemental file 2 - Fig. S1A and B (Mature MMP-14 is increased in membrane preparations in the presence of MMPI, and MMPI Prinomastat does not affect cell morphology).
  PDF document, 653K.
• Supplemental file 3 - Fig. S1C and D (MMPI Prinomastat does not affect cell proliferation or apoptosis).
  PDF document, 90K.
• Supplemental file 4 - Fig. S2 (Specificity of Prinomastat for various MMPs and MDA-MB-231 cell secretion of MMP-2).
  PDF document, 83K.
• Supplemental file 5 - Fig. S3 (Some novel MMP-14 substrates are also processed by other MMPs).
  PDF document, 549K.
• Supplemental file 6 - Fig. S4 (A peptide spanning the uPAR D1-D2 linker but not the D3 juxtamembrane site is cleaved by MMPs).
  PDF document, 68K.