WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2^B-Mediated Telomere Shortening

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 - Legends to Fig. S1 to S6
  Zipped MS Word document, 9K.
• Supplemental file 2 - Fig. S1 (TRF2^ΔB induction of TIFs)
  Zipped EPS file, 2MB.
• Supplemental file 3 - Fig. S2 (Examples of the method used for quantification of telomeric signal)
  Zipped EPS file, 4MB.
• Supplemental file 4 - Fig. S3 (Southern blot analysis of telomeric DNA in genetically complemented WS cells)
  Zipped EPS file, 672KB.
• Supplemental file 5 - Fig. S4 (Quality control of blotted DNA and telomeric circles signal quantification)
  Zipped EPS file, 6MB.
• Supplemental file 6 - Fig. S5 (Extrachromosomal double-stranded DNA circles are present in telomerase-positive WS fibroblasts)
  Zipped EPS file, 10MB.
• Supplemental file 7 - Fig. S6 (Telomeric circles are present in telomerase-positive WS fibroblasts in the absence of TRF2^ΔB)
  Zipped EPS file, 2MB.