Files in this Data Supplement:

• Supplemental file 1 - Table SI (Change in 624 genes identified as regulated)
  Zipped Excel file, 1.7MB.
• Supplemental file 2 - Table SII (Resume of Affymetrix GeneChips expression profiling statistic)
  Zipped Excel file, 6K.
• Supplemental file 3 - Fig. S1 (Subcellular localization of CTFs), S2 (Biochemical characterization of cell lines), S3 (Western blot identification of 611-CTFs), S4 (HER2 expression in stable clone and tumors), S5 (Autophosphorylation activity of HER2 and CTF constructs), S6 (Signaling pathway activation in cells used for transcriptomic analysis), S7 (Resume and validation of transcriptomic analysis), S8 (MMP1 expression regulation by 611-CTF), S9 (Protein levels corresponding to 611-CTF-upregulated genes), S10 (Transcriptomic analysis of primary human breast tumors), S11 (Gene signature of preferentially 611-CTF-upregulated targets), S12 (Homodimerization of 611-CTF via extracellular cysteine residues), S13 (Primary tumors and lung metastases in transgenic animals), and S14 (Mutations in transgenes of tumors from TG HER2 mice)
  Zipped PDF file, 4.2MB.