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Cysteine Oxidation Regulates the RNA-Binding Activity of Iron Regulatory Protein 2
Mol. Cell. Biol. Zumbrennen et al. 29: 2219

Supplemental material

Files in this Data Supplement:

  • Supplemental file 1 - Fig. S1 (Iron-dependent degradation of IRP1 and IRP2), S2 (IRP2 cysteine mutant sensitivity to diamide), S3 (IRP1-S441C mutant lacks RNA binding and aconitase activity), S4 (Nutrient deprivation reduces IRP2 RNA-binding activity without DFO treatment), and S5 (IRP2-C512 and IRP2-C516 are required for sensitivity to nutrient deprivation) and Table S1 (Primer sequences for site-directed mutagenesis).
    PDF file, 1MB.



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