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Mol. Cell. Biol., 01 1995, 35-44, Vol 15, No. 1
Copyright © 1995, American Society for Microbiology

Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes

S Vagner, MC Gensac, A Maret, F Bayard, F Amalric, H Prats and AC Prats
INSERM U397, Endocrinologie et Communication Cellulaire, Institut Louis Bugnard, Centre Hospitalier Universitaire de Rangueil, Toulouse, France.

Alternative initiations of translation of the human fibroblast growth factor 2 (FGF-2) mRNA, at three CUG start codons and one AUG start codon, result in the synthesis of four isoforms of FGF-2. This process has important consequences on the fate of FGF-2: the CUG-initiated products are nuclear and their constitutive expression is able to induce cell immortalization, whereas the AUG-initiated product, mostly cytoplasmic, can generate cell transformation. Thus, the different isoforms probably have distinct targets in the cell. We show here that translation initiation of the FGF-2 mRNA breaks the rule of the cap- dependent ribosome scanning mechanism. First, translation of the FGF-2 mRNA was shown to be cap independent in vitro. This cap-independent translation required a sequence located between nucleotides (nt) 192 and 256 from the 5' end of the 318-nt-long 5' untranslated region. Second, expression of bicistronic vectors in COS-7 cells indicated that the FGF-2 mRNA is translated through a process of internal ribosome entry mediated by the mRNA leader sequence. By introducing additional AUG codons into the RNA leader sequence, we localized an internal ribosome entry site to between nt 154 and 318 of the 5' untranslated region, just upstream of the first CUG. The presence of an internal ribosome entry site in the FGF-2 mRNA suggests that the process of internal translation initiation, by controlling the expression of a growth factor, could have a crucial role in the control of cell proliferation and differentiation.


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  • Bai, C., Tolias, P. P. (2000). Genetic analysis of a La homolog in Drosophila melanogaster. Nucleic Acids Res 28: 1078-1084 [Abstract] [Full Text]  
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  • Henis-Korenblit, S., Strumpf, N. L., Goldstaub, D., Kimchi, A. (2000). A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation. Mol. Cell. Biol. 20: 496-506 [Abstract] [Full Text]  
  • Deffaud, C., Darlix, J.-L. (2000). Characterization of an Internal Ribosomal Entry Segment in the 5' Leader of Murine Leukemia Virus env RNA. J. Virol. 74: 846-850 [Abstract] [Full Text]  
  • Kim, Y. K., Jang, S. K. (1999). La protein is required for efficient translation driven by encephalomyocarditis virus internal ribosomal entry site. J. Gen. Virol. 80: 3159-3166 [Abstract] [Full Text]  
  • Fawaz, L. M., Sharif-Askari, E., Menezes, J. (1999). Up-Regulation of NK Cytotoxic Activity Via IL-15 Induction by Different Viruses: A Comparative Study. J. Immunol. 163: 4473-4480 [Abstract] [Full Text]  
  • Lopez-Lastra, M., Ulrici, S., Gabus, C., Darlix, J.-L. (1999). Identification of an Internal Ribosome Entry Segment in the 5' Region of the Mouse VL30 Retrotransposon and Its Use in the Development of Retroviral Vectors. J. Virol. 73: 8393-8402 [Abstract] [Full Text]  
  • Sella, O., Gerlitz, G., Le, S.-Y., Elroy-Stein, O. (1999). Differentiation-Induced Internal Translation of c-sis mRNA: Analysis of the cis Elements and Their Differentiation-Linked Binding to the hnRNP C Protein. Mol. Cell. Biol. 19: 5429-5440 [Abstract] [Full Text]  
  • Paz, I., Abramovitz, L., Choder, M. (1999). Starved Saccharomyces cerevisiae Cells Have the Capacity to Support Internal Initiation of Translation. J. Biol. Chem. 274: 21741-21745 [Abstract] [Full Text]  
  • Touriol, C., Morillon, A., Gensac, M.-C., Prats, H., Prats, A.-C. (1999). Expression of Human Fibroblast Growth Factor 2 mRNA Is Post-transcriptionally Controlled by a Unique Destabilizing Element Present in the 3'-Untranslated Region between Alternative Polyadenylation Sites. J. Biol. Chem. 274: 21402-21408 [Abstract] [Full Text]  
  • Krichevsky, A. M., Metzer, E., Rosen, H. (1999). Translational Control of Specific Genes during Differentiation of HL-60 Cells. J. Biol. Chem. 274: 14295-14305 [Abstract] [Full Text]  
  • Arese, M., Chen, Y., Florkiewicz, R. Z., Gualandris, A., Shen, B., Rifkin, D. B. (1999). Nuclear Activities of Basic Fibroblast Growth Factor: Potentiation of Low-Serum Growth Mediated by Natural or Chimeric Nuclear Localization Signals. Mol. Biol. Cell 10: 1429-1444 [Abstract] [Full Text]  
  • Tillotson, L. G. (1999). RIN ZF, a Novel Zinc Finger Gene, Encodes Proteins That Bind to the CACC Element of the Gastrin Promoter. J. Biol. Chem. 274: 8123-8128 [Abstract] [Full Text]  
  • Sasaki, J., Nakashima, N. (1999). Translation Initiation at the CUU Codon Is Mediated by the Internal Ribosome Entry Site of an Insect Picorna-Like Virus In Vitro. J. Virol. 73: 1219-1226 [Abstract] [Full Text]  
  • Arnaud, E., Touriol, C., Boutonnet, C., Gensac, M.-C., Vagner, S., Prats, H., Prats, A.-C. (1999). A New 34-Kilodalton Isoform of Human Fibroblast Growth Factor 2 Is Cap Dependently Synthesized by Using a Non-AUG Start Codon and Behaves as a Survival Factor. Mol. Cell. Biol. 19: 505-514 [Abstract] [Full Text]  
  • Galy, B., Maret, A., Prats, A.-C., Prats, H. (1999). Cell Transformation Results in the Loss of the Density-dependent Translational Regulation of the Expression of Fibroblast Growth Factor 2 Isoforms. Cancer Res. 59: 165-171 [Abstract] [Full Text]  
  • McCarthy, J. E. G. (1998). Posttranscriptional Control of Gene Expression in Yeast. Microbiol. Mol. Biol. Rev. 62: 1492-1553 [Abstract] [Full Text]  
  • Huez, I., Créancier, L., Audigier, S., Gensac, M.-C., Prats, A.-C., Prats, H. (1998). Two Independent Internal Ribosome Entry Sites Are Involved in Translation Initiation of Vascular Endothelial Growth Factor mRNA. Mol. Cell. Biol. 18: 6178-6190 [Abstract] [Full Text]  
  • Iliopoulos, O., Ohh, M., Kaelin, W. G. Jr. (1998). pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc. Natl. Acad. Sci. USA 95: 11661-11666 [Abstract] [Full Text]  
  • Malyak, M., Guthridge, J. M., Hance, K. R., Dower, S. K., Freed, J. H., Arend, W. P. (1998). Characterization of a Low Molecular Weight Isoform of IL-1 Receptor Antagonist. J. Immunol. 161: 1997-2003 [Abstract] [Full Text]  
  • Negulescu, D., Leong, L. E.-C., Chandy, K. G., Semler, B. L., Gutman, G. A. (1998). Translation Initiation of a Cardiac Voltage-gated Potassium Channel by Internal Ribosome Entry. J. Biol. Chem. 273: 20109-20113 [Abstract] [Full Text]  
  • Schoenfeld, A., Davidowitz, E. J., Burk, R. D. (1998). A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc. Natl. Acad. Sci. USA 95: 8817-8822 [Abstract] [Full Text]  
  • Stein, I., Itin, A., Einat, P., Skaliter, R., Grossman, Z., Keshet, E. (1998). Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia. Mol. Cell. Biol. 18: 3112-3119 [Abstract] [Full Text]  
  • Gan, W., Celle, M. L., Rhoads, R. E. (1998). Functional Characterization of the Internal Ribosome Entry Site of eIF4G mRNA. J. Biol. Chem. 273: 5006-5012 [Abstract] [Full Text]  
  • Nanbru, C., Lafon, I., Audigier, S., Gensac, M.-C., Vagner, S., Huez, G., Prats, A.-C. (1997). Alternative Translation of the Proto-oncogene c-myc by an Internal Ribosome Entry Site. J. Biol. Chem. 272: 32061-32066 [Abstract] [Full Text]  
  • Bernstein, J., Sella, O., Le, S.-Y., Elroy-Stein, O. (1997). PDGF2/c-sis mRNA Leader Contains a Differentiation-linked Internal Ribosomal Entry Site (D-IRES). J. Biol. Chem. 272: 9356-9362 [Abstract] [Full Text]  
  • Bikfalvi, A., Klein, S., Pintucci, G., Rifkin, D. B. (1997). Biological Roles of Fibroblast Growth Factor-2. Endocr. Rev. 18: 26-45 [Abstract] [Full Text]  
  • Yamanaka, S, Poksay, K S, Arnold, K S, Innerarity, T L (1997). A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme.. Genes Dev. 11: 321-333 [Abstract]  
  • Mauro, V. P., Edelman, G. M. (1997). rRNA-like sequences occur in diverse primary transcripts: Implications for the control of gene expression. Proc. Natl. Acad. Sci. USA 94: 422-427 [Abstract] [Full Text]  
  • Peifley, K. A., Alberts, G. F., Hsu, D. K.W., Feng, S.-L. Y., Winkles, J. A. (1996). Heparin-Binding Epidermal Growth Factor-Like Growth Factor Regulates Fibroblast Growth Factor-2 Expression in Aortic Smooth Muscle Cells. Circ. Res. 79: 263-270 [Abstract] [Full Text]  
  • Bruening, W., Pelletier, J. (1996). A Non-AUG Translational Initiation Event Generates Novel WT1 Isoforms. J. Biol. Chem. 271: 8646-8654 [Abstract] [Full Text]  
  • Gan, W., Rhoads, R. E. (1996). Internal Initiation of Translation Directed by the 5`-Untranslated Region of the mRNA for eIF4G, a Factor Involved in the Picornavirus-induced Switch from Cap-dependent to Internal Initiation. J. Biol. Chem. 271: 623-626 [Abstract] [Full Text]  
  • Vagner, S.ép., Waysbort, A., Marenda, M., Gensac, M.-C., Amalric, F.ço., Prats, A.-C. (1995). Alternative Translation Initiation of the Moloney Murine Leukemia Virus mRNA Controlled by Internal Ribosome Entry Involving the p57/PTB Splicing Factor. J. Biol. Chem. 270: 20376-20383 [Abstract] [Full Text]  
  • Bernstein, J., Shefler, I., Elroy-Stein, O. (1995). The Translational Repression Mediated by the Platelet-derived Growth Factor 2/c- sis mRNA Leader Is Relieved during Megakaryocytic Differentiation. J. Biol. Chem. 270: 10559-10565 [Abstract] [Full Text]  
  • Gaubert, F., Escaffit, F., Bertrand, C., Korc, M., Pradayrol, L., Clemente, F., Estival, A. (2001). Expression of the High Molecular Weight Fibroblast Growth Factor-2 Isoform of 210 Amino Acids Is Associated with Modulation of Protein Kinases C delta and epsilon and ERK Activation. J. Biol. Chem. 276: 1545-1554 [Abstract] [Full Text]  
  • Guittaut, M., Charpentier, S., Normand, T., Dubois, M., Raimond, J., Legrand, A. (2001). Identification of an Internal Gene to the Human Galectin-3 Gene with Two Different Overlapping Reading Frames That Do Not Encode Galectin-3. J. Biol. Chem. 276: 2652-2657 [Abstract] [Full Text]  
  • Watada, H., Mirmira, R. G., Leung, J., German, M. S. (2000). Transcriptional and Translational Regulation of beta -Cell Differentiation Factor Nkx6.1. J. Biol. Chem. 275: 34224-34230 [Abstract] [Full Text]  
  • Giraud, S., Greco, A., Brink, M., Diaz, J.-J., Delafontaine, P. (2001). Translation Initiation of the Insulin-like Growth Factor I Receptor mRNA Is Mediated by an Internal Ribosome Entry Site. J. Biol. Chem. 276: 5668-5675 [Abstract] [Full Text]  
  • Touriol, C., Roussigne, M., Gensac, M.-C., Prats, H., Prats, A.-C. (2000). Alternative Translation Initiation of Human Fibroblast Growth Factor 2 mRNA Controlled by Its 3'-Untranslated Region Involves a Poly(A) Switch and a Translational Enhancer. J. Biol. Chem. 275: 19361-19367 [Abstract] [Full Text]  


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