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Mol. Cell. Biol., 10 1995, 5770-5776, Vol 15, No. 10
Copyright © 1995, American Society for Microbiology

The cellular response to neuregulins is governed by complex interactions of the erbB receptor family [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735]

DJ Riese 2nd, TM van Raaij, GD Plowman, GC Andrews and DF Stern
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.

Deregulated signaling by the four members of the epidermal growth factor receptor tyrosine kinase family (erbB family) is implicated in the genesis or progression of human cancers. However, efforts to analyze signaling by these receptors have been hampered by the diversity of ligands and extensive interreceptor cross talk. We have expressed the four human erbB family receptors, singly and in pairwise combinations, in a pro-B-lymphocyte cell line (Ba/F3) and investigated the range of interactions activated by the epidermal growth factor homology domain of the agonist neuregulin beta. The results provide the first comprehensive analysis of the response of this receptor family to a single peptide agonist. This peptide induced complex patterns of receptor tyrosine phosphorylation and regulation of Ba/F3 cell survival and proliferation. These data demonstrate the existence of several previously undocumented receptor interactions driven by neuregulin.


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  • Thor, A. D., Liu, S., Edgerton, S., Moore, D. II, Kasowitz, K. M., Benz, C. C., Stern, D. F., DiGiovanna, M. P. (2000). Activation (Tyrosine Phosphorylation) of ErbB-2 (HER-2/neu): A Study of Incidence and Correlation With Outcome in Breast Cancer. JCO 18: 3230-3239 [Abstract] [Full Text]  
  • Tang, C. K., Gong, X.-Q., Moscatello, D. K., Wong, A. J., Lippman, M. E. (2000). Epidermal Growth Factor Receptor vIII Enhances Tumorigenicity in Human Breast Cancer. Cancer Res. 60: 3081-3087 [Abstract] [Full Text]  
  • Patel, N. V., Acarregui, M. J., Snyder, J. M., Klein, J. M., Sliwkowski, M. X., Kern, J. A. (2000). Neuregulin-1 and Human Epidermal Growth Factor Receptors 2 and 3 Play a Role in Human Lung Development In Vitro. Am. J. Respir. Cell Mol. Bio. 22: 432-440 [Abstract] [Full Text]  
  • Miettinen, P., Huotari, M, Koivisto, T, Ustinov, J, Palgi, J, Rasilainen, S, Lehtonen, E, Keski-Oja, J, Otonkoski, T (2000). Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development 127: 2617-2627 [Abstract]  
  • Russell, K. S., Stern, D. F., Polverini, P. J., Bender, J. R. (1999). Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis. Am. J. Physiol. Heart Circ. Physiol. 277: H2205-H2211 [Abstract] [Full Text]  
  • Jones, F. E., Welte, T., Fu, X.-Y., Stern, D. F. (1999). Erbb4 Signaling in the Mammary Gland Is Required for Lobuloalveolar Development and Stat5 Activation during Lactation. JCB 147: 77-88 [Abstract] [Full Text]  
  • Muthuswamy, S. K., Gilman, M., Brugge, J. S. (1999). Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers. Mol. Cell. Biol. 19: 6845-6857 [Abstract] [Full Text]  
  • Saxon, M. L., Lee, D. C. (1999). Mutagenesis Reveals a Role for Epidermal Growth Factor Receptor Extracellular Subdomain IV in Ligand Binding. J. Biol. Chem. 274: 28356-28362 [Abstract] [Full Text]  
  • Polosa, R., Prosperini, G., Leir, S.-H., Holgate, S. T., Lackie, P. M., Davies, D. E. (1999). Expression of c-erbB Receptors and Ligands in Human Bronchial Mucosa. Am. J. Respir. Cell Mol. Bio. 20: 914-923 [Abstract] [Full Text]  
  • Klapper, L. N., Glathe, S., Vaisman, N., Hynes, N. E., Andrews, G. C., Sela, M., Yarden, Y. (1999). The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc. Natl. Acad. Sci. USA 96: 4995-5000 [Abstract] [Full Text]  
  • Bianco, C., Kannan, S., De Santis, M., Seno, M., Tang, C. K., Martinez-Lacaci, I., Kim, N., Wallace-Jones, B., Lippman, M. E., Ebert, A. D., Wechselberger, C., Salomon, D. S. (1999). Cripto-1 Indirectly Stimulates the Tyrosine Phosphorylation of erb B-4 through a Novel Receptor. J. Biol. Chem. 274: 8624-8629 [Abstract] [Full Text]  
  • Qian, X., O'Rourke, D. M., Fei, Z., Zhang, H.-T., Kao, C.-C., Greene, M. I. (1999). Domain-specific Interactions between the p185neu and Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes. J. Biol. Chem. 274: 574-583 [Abstract] [Full Text]  
  • Schaefer, G., Akita, R. W., Sliwkowski, M. X. (1999). A Discrete Three-amino Acid Segment (LVI) at the C-terminal End of Kinase-impaired ErbB3 Is Required for Transactivation of ErbB2. J. Biol. Chem. 274: 859-866 [Abstract] [Full Text]  
  • Felts, P. A. (1999). Neuregulins in Schwann Cell Development. Neuroscientist 5: 8-11 [Abstract]  
  • Sundaresan, S., Roberts, P. E., King, K. L., Sliwkowski, M. X., Mather, J. P. (1998). Biological Response to ErbB Ligands in Nontransformed Cell Lines Correlates with a Specific Pattern of Receptor Expression. Endocrinology 139: 4756-4764 [Abstract] [Full Text]  
  • Schroering, A., Carey, D. J. (1998). Sensory and Motor Neuron-derived Factor Is a Transmembrane Heregulin That Is Expressed on the Plasma Membrane with the Active Domain Exposed to the Extracellular Environment. J. Biol. Chem. 273: 30643-30650 [Abstract] [Full Text]  
  • Rahmatullah, M., Schroering, A., Rothblum, K., Stahl, R. C., Urban, B., Carey, D. J. (1998). Synergistic Regulation of Schwann Cell Proliferation by Heregulin and Forskolin. Mol. Cell. Biol. 18: 6245-6252 [Abstract] [Full Text]  
  • Niemann, C., Brinkmann, V., Spitzer, E., Hartmann, G., Sachs, M., Naundorf, H., Birchmeier, W. (1998). Reconstitution of Mammary Gland Development In Vitro: Requirement of c-met and c-erbB2 Signaling for Branching and Alveolar Morphogenesis. JCB 143: 533-545 [Abstract] [Full Text]  
  • Crovello, C. S., Lai, C., Cantley, L. C., Carraway III, K. L. (1998). Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2. J. Biol. Chem. 273: 26954-26961 [Abstract] [Full Text]  
  • Pinkas-Kramarski, R., Shelly, M., Guarino, B. C., Wang, L. M., Lyass, L., Alroy, I., Alamandi, M., Kuo, A., Moyer, J. D., Lavi, S., Eisenstein, M., Ratzkin, B. J., Seger, R., Bacus, S. S., Pierce, J. H., Andrews, G. C., Yarden, Y. (1998). ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network. Mol. Cell. Biol. 18: 6090-6101 [Abstract] [Full Text]  
  • Britsch, S., Li, L., Kirchhoff, S., Theuring, F., Brinkmann, V., Birchmeier, C., Riethmacher, D. (1998). The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12: 1825-1836 [Abstract] [Full Text]  
  • Wang, L.-M., Kuo, A., Alimandi, M., Veri, M. C., Lee, C.-C., Kapoor, V., Ellmore, N., Chen, X.-H., Pierce, J. H. (1998). ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4. Proc. Natl. Acad. Sci. USA 95: 6809-6814 [Abstract] [Full Text]  
  • Cunnick, J. M., Dorsey, J. F., Standley, T., Turkson, J., Kraker, A. J., Fry, D. W., Jove, R., Wu, J. (1998). Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway. J. Biol. Chem. 273: 14468-14475 [Abstract] [Full Text]  
  • Waterman, H., Sabanai, I., Geiger, B., Yarden, Y. (1998). Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency. J. Biol. Chem. 273: 13819-13827 [Abstract] [Full Text]  
  • Jones, J. T., Ballinger, M. D., Pisacane, P. I., Lofgren, J. A., Fitzpatrick, V. D., Fairbrother, W. J., Wells, J. A., Sliwkowski, M. X. (1998). Binding Interaction of the Heregulinbeta egf Domain with ErbB3 and ErbB4 Receptors Assessed by Alanine Scanning Mutagenesis. J. Biol. Chem. 273: 11667-11674 [Abstract] [Full Text]  
  • Riese II, D. J., Komurasaki, T., Plowman, G. D., Stern, D. F. (1998). Activation of ErbB4 by the Bifunctional Epidermal Growth Factor Family Hormone Epiregulin Is Regulated by ErbB2. J. Biol. Chem. 273: 11288-11294 [Abstract] [Full Text]  
  • Huotari, M.-A., Palgi, J., Otonkoski, T. (1998). Growth Factor-Mediated Proliferation and Differentiation of Insulin-Producing INS-1 and RINm5F Cells: Identification of Betacellulin as a Novel {beta}-Cell Mitogen. Endocrinology 139: 1494-1499 [Abstract] [Full Text]  
  • Fiddes, R. J., Campbell, D. H., Janes, P. W., Sivertsen, S. P., Sasaki, H., Wallasch, C., Daly, R. J. (1998). Analysis of Grb7 Recruitment by Heregulin-activated erbB Receptors Reveals a Novel Target Selectivity for erbB3. J. Biol. Chem. 273: 7717-7724 [Abstract] [Full Text]  
  • Eilam, R., Pinkas-Kramarski, R., Ratzkin, B. J., Segal, M., Yarden, Y. (1998). Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain. Proc. Natl. Acad. Sci. USA 95: 1888-1893 [Abstract] [Full Text]  
  • Zhang, D., Sliwkowski, M. X., Mark, M., Frantz, G., Akita, R., Sun, Y., Hillan, K., Crowley, C., Brush, J., Godowski, P. J. (1997). Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4. Proc. Natl. Acad. Sci. USA 94: 9562-9567 [Abstract] [Full Text]  
  • Subramony, P., Dryer, S. E. (1997). Neuregulins stimulate the functional expression of Ca2+-activated K+ channels in developing chicken parasympathetic neurons. Proc. Natl. Acad. Sci. USA 94: 5934-5938 [Abstract] [Full Text]  
  • Kannan, S., De Santis, M., Lohmeyer, M., Riese, D. J. II, Smith, G. H., Hynes, N., Seno, M., Brandt, R., Bianco, C., Persico, G., Kenney, N., Normanno, N., Martinez-Lacaci, I., Ciardiello, F., Stern, D. F., Gullick, W. J., Salomon, D. S. (1997). Cripto Enhances the Tyrosine Phosphorylation of Shc and Activates Mitogen-activated Protein Kinase (MAPK) in Mammary Epithelial Cells. J. Biol. Chem. 272: 3330-3335 [Abstract] [Full Text]  
  • Cohen, B. D., Kiener, P. A., Green, J. M., Foy, L., Fell, H. P., Zhang, K. (1996). The Relationship between Human Epidermal Growth-like Factor Receptor Expression and Cellular Transformation in NIH3T3 Cells. J. Biol. Chem. 271: 30897-30903 [Abstract] [Full Text]  
  • Riese, D. J. II, Kim, E. D., Elenius, K., Buckley, S., Klagsbrun, M., Plowman, G. D., Stern, D. F. (1996). The Epidermal Growth Factor Receptor Couples Transforming Growth Factor-alpha , Heparin-binding Epidermal Growth Factor-like Factor, and Amphiregulin to Neu, ErbB-3, and ErbB-4. J. Biol. Chem. 271: 20047-20052 [Abstract] [Full Text]  
  • Pinkas-Kramarski, R., Shelly, M., Glathe, S., Ratzkin, B. J., Yarden, Y. (1996). Neu Differentiation Factor/Neuregulin Isoforms Activate Distinct Receptor Combinations. J. Biol. Chem. 271: 19029-19032 [Abstract] [Full Text]  
  • Vecchi, M., Baulida, J., Carpenter, G. (1996). Selective Cleavage of the Heregulin Receptor ErbB-4 by Protein Kinase C Activation. J. Biol. Chem. 271: 18989-18995 [Abstract] [Full Text]  
  • Carver, R. S., Sliwkowski, M. X., Sitaric, S., Russell, W. E. (1996). Insulin Regulates Heregulin Binding and ErbB3 Expression in Rat Hepatocytes. J. Biol. Chem. 271: 13491-13496 [Abstract] [Full Text]  
  • Sweeney, C., Fambrough, D., Huard, C., Diamonti, A. J., Lander, E. S., Cantley, L. C., Carraway, K. L. III (2001). Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors. J. Biol. Chem. 276: 22685-22698 [Abstract] [Full Text]  


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