This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kozma, R.
Right arrow Articles by Lim, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kozma, R.
Right arrow Articles by Lim, L.

 Previous Article  |  Next Article 

Mol. Cell. Biol., 04 1995, 1942-1952, Vol 15, No. 4
Copyright © 1995, American Society for Microbiology

The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts

R Kozma, S Ahmed, A Best and L Lim
Institute of Neurology, London, United Kingdom.

The Ras-related protein Cdc42 plays a role in yeast cell budding and polarity. Two related proteins, Rac1 and RhoA, promote formation in mammalian cells of membrane ruffles and stress fibers, respectively, which contain actin microfilaments. We now show that microinjection of the related human Cdc42Hs into Swiss 3T3 fibroblasts induced the formation of peripheral actin microspikes, determined by staining with phalloidin. A proportion of these microspikes was found to be components of filopodia, as analyzed by time-lapse phase-contrast microscopy. The formation of filopodia was also found to be promoted by Cdc42Hs microinjection. This was followed by activation of Rac1- mediated membrane ruffling. Treatment with bradykinin also promoted formation of microspikes and filopodia as well as subsequent effects similar to that seen upon Cdc42Hs microinjection. These effects of bradykinin were specifically inhibited by prior microinjection of dominant negative Cdc42HsT17N, suggesting that bradykinin acts by activating cellular Cdc42Hs. Since filopodia have been ascribed an important sensory function in fibroblasts and are required for guidance of neuronal growth cones, these results indicate that Cdc42Hs plays an important role in determining mammalian cell morphology.


This article has been cited by other articles:

  • Teng, T. S., Lin, B., Manser, E., Ng, D. C. H., Cao, X. (2009). Stat3 promotes directional cell migration by regulating Rac1 activity via its activator {beta}PIX. J. Cell Sci. 122: 4150-4159 [Abstract] [Full Text]  
  • Johnson, J. L., Erickson, J. W., Cerione, R. A. (2009). New Insights into How the Rho Guanine Nucleotide Dissociation Inhibitor Regulates the Interaction of Cdc42 with Membranes. J. Biol. Chem. 284: 23860-23871 [Abstract] [Full Text]  
  • Liu, Z., Adams, H. C. III, Whitehead, I. P. (2009). The Rho-specific Guanine Nucleotide Exchange Factor Dbs Regulates Breast Cancer Cell Migration. J. Biol. Chem. 284: 15771-15780 [Abstract] [Full Text]  
  • Bu, W., Chou, A. M., Lim, K. B., Sudhaharan, T., Ahmed, S. (2009). The Toca-1-N-WASP Complex Links Filopodial Formation to Endocytosis. J. Biol. Chem. 284: 11622-11636 [Abstract] [Full Text]  
  • Barber, P.R, Ameer-Beg, S.M, Gilbey, J, Carlin, L.M, Keppler, M, Ng, T.C, Vojnovic, B (2009). Multiphoton time-domain fluorescence lifetime imaging microscopy: practical application to protein-protein interactions using global analysis. J R Soc Interface 6: S93-S105 [Abstract] [Full Text]  
  • Chandra Roy, B., Kakinuma, N., Kiyama, R. (2009). Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. JCB 184: 253-267 [Abstract] [Full Text]  
  • Schramp, M., Ying, O., Kim, T. Y., Martin, G. S. (2008). ERK5 promotes Src-induced podosome formation by limiting Rho activation. JCB 181: 1195-1210 [Abstract] [Full Text]  
  • Yin, J., Yu, F.-S. X. (2008). Rho kinases regulate corneal epithelial wound healing. Am. J. Physiol. Cell Physiol. 295: C378-C387 [Abstract] [Full Text]  
  • Jeganathan, S., Morrow, A., Amiri, A., Lee, J. M. (2008). Eukaryotic Elongation Factor 1A2 Cooperates with Phosphatidylinositol-4 Kinase III {beta} To Stimulate Production of Filopodia through Increased Phosphatidylinositol-4,5 Bisphosphate Generation. Mol. Cell. Biol. 28: 4549-4561 [Abstract] [Full Text]  
  • Yin, J., Lu, J., Yu, F.-S. X. (2008). Role of Small GTPase Rho in Regulating Corneal Epithelial Wound Healing. IOVS 49: 900-909 [Abstract] [Full Text]  
  • Nicola, C., Chirpac, A., Lala, P. K., Chakraborty, C. (2008). Roles of Rho Guanosine 5'-Triphosphatase A, Rho Kinases, and Extracellular Signal Regulated Kinase (1/2) in Prostaglandin E2-Mediated Migration of First-Trimester Human Extravillous Trophoblast. Endocrinology 149: 1243-1251 [Abstract] [Full Text]  
  • Marquez, M. G., del Carmen Fernandez-Tome, M., Favale, N. O., Pescio, L. G., Sterin-Speziale, N. B. (2008). Bradykinin modulates focal adhesions and induces stress fiber remodeling in renal papillary collecting duct cells. Am. J. Physiol. Renal Physiol. 294: F603-F613 [Abstract] [Full Text]  
  • Kimura, K., Teranishi, S., Yamauchi, J., Nishida, T. (2008). Role of JNK-Dependent Serine Phosphorylation of Paxillin in Migration of Corneal Epithelial Cells during Wound Closure. IOVS 49: 125-132 [Abstract] [Full Text]  
  • Shutes, A., Onesto, C., Picard, V., Leblond, B., Schweighoffer, F., Der, C. J. (2007). Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases. J. Biol. Chem. 282: 35666-35678 [Abstract] [Full Text]  
  • Gupton, S. L., Gertler, F. B. (2007). Filopodia: The Fingers That Do the Walking. Sci Signal 2007: re5-re5 [Abstract] [Full Text]  
  • Pommereit, D., Wouters, F. S. (2007). An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth. J. Cell Sci. 120: 2694-2705 [Abstract] [Full Text]  
  • Yanagida-Asanuma, E., Asanuma, K., Kim, K., Donnelly, M., Young Choi, H., Hyung Chang, J., Suetsugu, S., Tomino, Y., Takenawa, T., Faul, C., Mundel, P. (2007). Synaptopodin Protects Against Proteinuria by Disrupting Cdc42:IRSp53:Mena Signaling Complexes in Kidney Podocytes. Am. J. Pathol. 171: 415-427 [Abstract] [Full Text]  
  • Prag, S., Parsons, M., Keppler, M. D., Ameer-Beg, S. M., Barber, P., Hunt, J., Beavil, A. J., Calvert, R., Arpin, M., Vojnovic, B., Ng, T. (2007). Activated Ezrin Promotes Cell Migration through Recruitment of the GEF Dbl to Lipid Rafts and Preferential Downstream Activation of Cdc42. Mol. Biol. Cell 18: 2935-2948 [Abstract] [Full Text]  
  • Petrovic, N., Schacke, W., Gahagan, J. R., O'Conor, C. A., Winnicka, B., Conway, R. E., Mina-Osorio, P., Shapiro, L. H. (2007). CD13/APN regulates endothelial invasion and filopodia formation. Blood 110: 142-150 [Abstract] [Full Text]  
  • Hoffmann, C., Aktories, K., Schmidt, G. (2007). Change in Substrate Specificity of Cytotoxic Necrotizing Factor Unmasks Proteasome-independent Down-regulation of Constitutively Active RhoA. J. Biol. Chem. 282: 10826-10832 [Abstract] [Full Text]  
  • Kimura, K., Hattori, A., Usui, Y., Kitazawa, K., Naganuma, M., Kawamoto, K., Teranishi, S., Nomizu, M., Nishida, T. (2007). Stimulation of Corneal Epithelial Migration by a Synthetic Peptide (PHSRN) Corresponding to the Second Cell-Binding Site of Fibronectin. IOVS 48: 1110-1118 [Abstract] [Full Text]  
  • Hopkins, A. M., Pineda, A. A., Winfree, L. M., Brown, G. T., Laukoetter, M. G., Nusrat, A. (2007). Organized migration of epithelial cells requires control of adhesion and protrusion through Rho kinase effectors. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G806-G817 [Abstract] [Full Text]  
  • Mendoza-Naranjo, A., Gonzalez-Billault, C., Maccioni, R. B. (2007). Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases. J. Cell Sci. 120: 279-288 [Abstract] [Full Text]  
  • Modzelewska, K., Newman, L. P., Desai, R., Keely, P. J. (2006). Ack1 Mediates Cdc42-dependent Cell Migration and Signaling to p130Cas. J. Biol. Chem. 281: 37527-37535 [Abstract] [Full Text]  
  • Lin, Q., Yang, W., Baird, D., Feng, Q., Cerione, R. A. (2006). Identification of a DOCK180-related Guanine Nucleotide Exchange Factor That Is Capable of Mediating a Positive Feedback Activation of Cdc42. J. Biol. Chem. 281: 35253-35262 [Abstract] [Full Text]  
  • Henle, F., Leemhuis, J., Fischer, C., Bock, H. H., Lindemeyer, K., Feuerstein, T. J., Meyer, D. K. (2006). Gabapentin-Lactam Induces Dendritic Filopodia and Motility in Cultured Hippocampal Neurons. J. Pharmacol. Exp. Ther. 319: 181-191 [Abstract] [Full Text]  
  • Steffen, A., Faix, J., Resch, G. P., Linkner, J., Wehland, J., Small, J. V., Rottner, K., Stradal, T. E.B. (2006). Filopodia Formation in the Absence of Functional WAVE- and Arp2/3-Complexes. Mol. Biol. Cell 17: 2581-2591 [Abstract] [Full Text]  
  • Longhurst, D. M., Watanabe, M., Rothstein, J. D., Jackson, M. (2006). Interaction of PDZRhoGEF with Microtubule-associated Protein 1 Light Chains: LINK BETWEEN MICROTUBULES, ACTIN CYTOSKELETON, AND NEURONAL POLARITY. J. Biol. Chem. 281: 12030-12040 [Abstract] [Full Text]  
  • Tanaka, H., Katoh, H., Negishi, M. (2006). Pragmin, a Novel Effector of Rnd2 GTPase, Stimulates RhoA Activity. J. Biol. Chem. 281: 10355-10364 [Abstract] [Full Text]  
  • Hirsch, D. S., Shen, Y., Wu, W. J. (2006). Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of cdc42.. Cancer Res. 66: 3523-3530 [Abstract] [Full Text]  
  • Cernuda-Morollon, E., Ridley, A. J. (2006). Rho GTPases and Leukocyte Adhesion Receptor Expression and Function in Endothelial Cells. Circ. Res. 98: 757-767 [Abstract] [Full Text]  
  • Hui, E. K.-W., Barman, S., Tang, D. H.-P., France, B., Nayak, D. P. (2006). YRKL Sequence of Influenza Virus M1 Functions as the L Domain Motif and Interacts with VPS28 and Cdc42. J. Virol. 80: 2291-2308 [Abstract] [Full Text]  
  • Su, J.-L., Yang, C.-Y., Shih, J.-Y., Wei, L.-H., Hsieh, C.-Y., Jeng, Y.-M., Wang, M.-Y., Yang, P.-C., Kuo, M.-L. (2006). Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma.. Cancer Res. 66: 2553-2561 [Abstract] [Full Text]  
  • Phillips-Mason, P. J., Gates, T. J., Major, D. L., Sacks, D. B., Brady-Kalnay, S. M. (2006). The Receptor Protein-tyrosine Phosphatase PTP{micro} Interacts with IQGAP1. J. Biol. Chem. 281: 4903-4910 [Abstract] [Full Text]  
  • Tzima, E. (2006). Role of Small GTPases in Endothelial Cytoskeletal Dynamics and the Shear Stress Response. Circ. Res. 98: 176-185 [Abstract] [Full Text]  
  • Czuchra, A., Wu, X., Meyer, H., van Hengel, J., Schroeder, T., Geffers, R., Rottner, K., Brakebusch, C. (2005). Cdc42 Is Not Essential for Filopodium Formation, Directed Migration, Cell Polarization, and Mitosis in Fibroblastoid Cells. Mol. Biol. Cell 16: 4473-4484 [Abstract] [Full Text]  
  • He, H., Pannequin, J., Tantiongco, J.-P., Shulkes, A., Baldwin, G. S. (2005). Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G478-G488 [Abstract] [Full Text]  
  • Berkowitz, P., Hu, P., Liu, Z., Diaz, L. A., Enghild, J. J., Chua, M. P., Rubenstein, D. S. (2005). Desmosome Signaling: INHIBITION OF p38MAPK PREVENTS PEMPHIGUS VULGARIS IgG-INDUCED CYTOSKELETON REORGANIZATION. J. Biol. Chem. 280: 23778-23784 [Abstract] [Full Text]  
  • Wang, J.-B., Wu, W. J., Cerione, R. A. (2005). Cdc42 and Ras Cooperate to Mediate Cellular Transformation by Intersectin-L. J. Biol. Chem. 280: 22883-22891 [Abstract] [Full Text]  
  • Marler, K. J. M., Kozma, R., Ahmed, S., Dong, J.-M., Hall, C., Lim, L. (2005). Outgrowth of Neurites from NIE-115 Neuroblastoma Cells Is Prevented on Repulsive Substrates through the Action of PAK. Mol. Cell. Biol. 25: 5226-5241 [Abstract] [Full Text]  
  • Holly, S. P., Larson, M. K., Parise, L. V. (2005). The Unique N-Terminus of R-Ras Is Required for Rac Activation and Precise Regulation of Cell Migration. Mol. Biol. Cell 16: 2458-2469 [Abstract] [Full Text]  
  • Yang, Z., Rayala, S., Nguyen, D., Vadlamudi, R. K., Chen, S., Kumar, R. (2005). Pak1 Phosphorylation of Snail, a Master Regulator of Epithelial-to-Mesenchyme Transition, Modulates Snail's Subcellular Localization and Functions. Cancer Res. 65: 3179-3184 [Abstract] [Full Text]  
  • Shekarabi, M., Moore, S. W., Tritsch, N. X., Morris, S. J., Bouchard, J.-F., Kennedy, T. E. (2005). Deleted in Colorectal Cancer Binding Netrin-1 Mediates Cell Substrate Adhesion and Recruits Cdc42, Rac1, Pak1, and N-WASP into an Intracellular Signaling Complex That Promotes Growth Cone Expansion. J. Neurosci. 25: 3132-3141 [Abstract] [Full Text]  
  • Leeb-Lundberg, L. M. F., Marceau, F., Muller-Esterl, W., Pettibone, D. J., Zuraw, B. L. (2005). International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences. Pharmacol. Rev. 57: 27-77 [Abstract] [Full Text]  
  • Suzuki, T, Izumoto, S, Fujimoto, Y, Maruno, M, Ito, Y, Yoshimine, T (2005). Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion. J. Clin. Pathol. 58: 166-171 [Abstract] [Full Text]  
  • Vaidya, R. J., Ray, R. M., Johnson, L. R. (2005). MEK1 restores migration of polyamine-depleted cells by retention and activation of Rac1 in the cytoplasm. Am. J. Physiol. Cell Physiol. 288: C350-C359 [Abstract] [Full Text]  
  • Kole, T. P., Tseng, Y., Jiang, I., Katz, J. L., Wirtz, D. (2005). Intracellular Mechanics of Migrating Fibroblasts. Mol. Biol. Cell 16: 328-338 [Abstract] [Full Text]  
  • Gadea, G., Roger, L., Anguille, C., de Toledo, M., Gire, V., Roux, P. (2004). TNF{alpha} induces sequential activation of Cdc42- and p38/p53-dependent pathways that antagonistically regulate filopodia formation. J. Cell Sci. 117: 6355-6364 [Abstract] [Full Text]  
  • Desai, L. P., Aryal, A. M., Ceacareanu, B., Hassid, A., Waters, C. M. (2004). RhoA and Rac1 are both required for efficient wound closure of airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 287: L1134-L1144 [Abstract] [Full Text]  
  • Tonozuka, Y., Minoshima, Y., Bao, Y. C., Moon, Y., Tsubono, Y., Hatori, T., Nakajima, H., Nosaka, T., Kawashima, T., Kitamura, T. (2004). A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line. Blood 104: 3550-3557 [Abstract] [Full Text]  
  • Lunn, J. A., Rozengurt, E. (2004). Hyperosmotic Stress Induces Rapid Focal Adhesion Kinase Phosphorylation at Tyrosines 397 and 577: ROLE OF Src FAMILY KINASES AND Rho FAMILY GTPases. J. Biol. Chem. 279: 45266-45278 [Abstract] [Full Text]  
  • Chen, B.-C., Yu, C.-C., Lei, H.-C., Chang, M.-S., Hsu, M.-J., Huang, C.-L., Chen, M.-C., Sheu, J.-R., Chen, T.-F., Chen, T.-L., Inoue, H., Lin, C.-H. (2004). Bradykinin B2 Receptor Mediates NF-{kappa}B Activation and Cyclooxygenase-2 Expression via the Ras/Raf-1/ERK Pathway in Human Airway Epithelial Cells. J. Immunol. 173: 5219-5228 [Abstract] [Full Text]  
  • Hopkins, A. M., Bruewer, M., Brown, G. T., Pineda, A. A., Ha, J. J., Winfree, L. M., Walsh, S. V., Babbin, B. A., Nusrat, A. (2004). Epithelial cell spreading induced by hepatocyte growth factor influences paxillin protein synthesis and posttranslational modification. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G886-G898 [Abstract] [Full Text]  
  • Nalbant, P., Hodgson, L., Kraynov, V., Toutchkine, A., Hahn, K. M. (2004). Activation of Endogenous Cdc42 Visualized in Living Cells. Science 305: 1615-1619 [Abstract] [Full Text]  
  • Liang, X., Draghi, N. A., Resh, M. D. (2004). Signaling from Integrins to Fyn to Rho Family GTPases Regulates Morphologic Differentiation of Oligodendrocytes. J. Neurosci. 24: 7140-7149 [Abstract] [Full Text]  
  • Diebold, B. A., Fowler, B., Lu, J., Dinauer, M. C., Bokoch, G. M. (2004). Antagonistic Cross-talk between Rac and Cdc42 GTPases Regulates Generation of Reactive Oxygen Species. J. Biol. Chem. 279: 28136-28142 [Abstract] [Full Text]  
  • Kole, T. P., Tseng, Y., Huang, L., Katz, J. L., Wirtz, D. (2004). Rho Kinase Regulates the Intracellular Micromechanical Response of Adherent Cells to Rho Activation. Mol. Biol. Cell 15: 3475-3484 [Abstract] [Full Text]  
  • Martinez-Quiles, N., Ho, H.-Y. H., Kirschner, M. W., Ramesh, N., Geha, R. S. (2004). Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASP. Mol. Cell. Biol. 24: 5269-5280 [Abstract] [Full Text]  
  • Smallhorn, M., Murray, M. J., Saint, R. (2004). The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble. Development 131: 2641-2651 [Abstract] [Full Text]  
  • Gustavsson, A., Yuan, M., Fallman, M. (2004). Temporal Dissection of {beta}1-Integrin Signaling Indicates a Role for p130Cas-Crk in Filopodia Formation. J. Biol. Chem. 279: 22893-22901 [Abstract] [Full Text]  
  • Woodring, P. J., Meisenhelder, J., Johnson, S. A., Zhou, G.-L., Field, J., Shah, K., Bladt, F., Pawson, T., Niki, M., Pandolfi, P. P., Wang, J. Y.J., Hunter, T. (2004). c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. JCB 165: 493-503 [Abstract] [Full Text]  
  • Carter, J. H., Douglass, L. E., Deddens, J. A., Colligan, B. M., Bhatt, T. R., Pemberton, J. O., Konicek, S., Hom, J., Marshall, M., Graff, J. R. (2004). Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis. Clin. Cancer Res. 10: 3448-3456 [Abstract] [Full Text]  
  • Loo, T.-H., Ng, Y.-W., Lim, L., Manser, E. (2004). GIT1 Activates p21-Activated Kinase through a Mechanism Independent of p21 Binding. Mol. Cell. Biol. 24: 3849-3859 [Abstract] [Full Text]  
  • Kurokawa, K., Itoh, R. E., Yoshizaki, H., Nakamura, Y. O. T., Matsuda, M. (2004). Coactivation of Rac1 and Cdc42 at Lamellipodia and Membrane Ruffles Induced by Epidermal Growth Factor. Mol. Biol. Cell 15: 1003-1010 [Abstract] [Full Text]  
  • Pellegrino, M., Furmaniak-Kazmierczak, E., LeBlanc, J. C., Cho, T., Cao, K., Marcovina, S. M., Boffa, M. B., Cote, G. P., Koschinsky, M. L. (2004). The Apolipoprotein(a) Component of Lipoprotein(a) Stimulates Actin Stress Fiber Formation and Loss of Cell-Cell Contact in Cultured Endothelial Cells. J. Biol. Chem. 279: 6526-6533 [Abstract] [Full Text]  
  • Ke, Y., Wang, L., Pyle, W. G., de Tombe, P. P., Solaro, R. J. (2004). Intracellular Localization and Functional Effects of P21-Activated Kinase-1 (Pak1) in Cardiac Myocytes. Circ. Res. 94: 194-200 [Abstract] [Full Text]  
  • Debreceni, B., Gao, Y., Guo, F., Zhu, K., Jia, B., Zheng, Y. (2004). Mechanisms of Guanine Nucleotide Exchange and Rac-mediated Signaling Revealed by a Dominant Negative Trio Mutant. J. Biol. Chem. 279: 3777-3786 [Abstract] [Full Text]  
  • Balasenthil, S., Sahin, A. A., Barnes, C. J., Wang, R.-A., Pestell, R. G., Vadlamudi, R. K., Kumar, R. (2004). p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells. J. Biol. Chem. 279: 1422-1428 [Abstract] [Full Text]  
  • TASKEN, K., AANDAHL, E. M. (2004). Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A. Physiol. Rev. 84: 137-167 [Abstract] [Full Text]  
  • Qiang, Y.-W., Yao, L., Tosato, G., Rudikoff, S. (2004). Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells. Blood 103: 301-308 [Abstract] [Full Text]  
  • Jiang, W. G., Watkins, G., Lane, J., Cunnick, G. H., Douglas-Jones, A., Mokbel, K., Mansel, R. E. (2003). Prognostic Value of Rho GTPases and Rho Guanine Nucleotide Dissociation Inhibitors in Human Breast Cancers. Clin. Cancer Res. 9: 6432-6440 [Abstract] [Full Text]  
  • Tu, S., Wu, W. J., Wang, J., Cerione, R. A. (2003). Epidermal Growth Factor-dependent Regulation of Cdc42 Is Mediated by the Src Tyrosine Kinase. J. Biol. Chem. 278: 49293-49300 [Abstract] [Full Text]  
  • Tufvesson, E., Westergren-Thorsson, G. (2003). Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration. J. Cell Sci. 116: 4857-4864 [Abstract] [Full Text]  
  • Shang, X., Zhou, Y. T., Low, B. C. (2003). Concerted Regulation of Cell Dynamics by BNIP-2 and Cdc42GAP Homology/Sec14p-like, Proline-rich, and GTPase-activating Protein Domains of a Novel Rho GTPase-activating Protein, BPGAP1. J. Biol. Chem. 278: 45903-45914 [Abstract] [Full Text]  
  • Tanabe, K., Bonilla, I., Winkles, J. A., Strittmatter, S. M. (2003). Fibroblast Growth Factor-Inducible-14 Is Induced in Axotomized Neurons and Promotes Neurite Outgrowth. J. Neurosci. 23: 9675-9686 [Abstract] [Full Text]  
  • Mataraza, J. M., Briggs, M. W., Li, Z., Entwistle, A., Ridley, A. J., Sacks, D. B. (2003). IQGAP1 Promotes Cell Motility and Invasion. J. Biol. Chem. 278: 41237-41245 [Abstract] [Full Text]  
  • Carton, I., Hermans, D., Eggermont, J. (2003). Hypotonicity induces membrane protrusions and actin remodeling via activation of small GTPases Rac and Cdc42 in Rat-1 fibroblasts. Am. J. Physiol. Cell Physiol. 285: C935-C944 [Abstract] [Full Text]  
  • Riley, K. N., Maldonado, A. E., Tellier, P., D'Souza-Schorey, C., Herman, I. M. (2003). {beta}cap73-ARF6 Interactions Modulate Cell Shape and Motility after Injury In Vitro. Mol. Biol. Cell 14: 4155-4161 [Abstract] [Full Text]  
  • Miao, H., Nickel, C. H., Cantley, L. G., Bruggeman, L. A., Bennardo, L. N., Wang, B. (2003). EphA kinase activation regulates HGF-induced epithelial branching morphogenesis. JCB 162: 1281-1292 [Abstract] [Full Text]  
  • Bogatkevich, G. S., Tourkina, E., Abrams, C. S., Harley, R. A., Silver, R. M., Ludwicka-Bradley, A. (2003). Contractile activity and smooth muscle {alpha}-actin organization in thrombin-induced human lung myofibroblasts. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L334-L343 [Abstract] [Full Text]  
  • Usui, I., Imamura, T., Huang, J., Satoh, H., Olefsky, J. M. (2003). Cdc42 Is a Rho GTPase Family Member That Can Mediate Insulin Signaling to Glucose Transport in 3T3-L1 Adipocytes. J. Biol. Chem. 278: 13765-13774 [Abstract] [Full Text]  
  • Guo, X., Stafford, L. J., Bryan, B., Xia, C., Ma, W., Wu, X., Liu, D., Songyang, Z., Liu, M. (2003). A Rac/Cdc42-specific Exchange Factor, GEFT, Induces Cell Proliferation, Transformation, and Migration. J. Biol. Chem. 278: 13207-13215 [Abstract] [Full Text]  
  • Masuda-Robens, J. M., Kutney, S. N., Qi, H., Chou, M. M. (2003). The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling. Mol. Cell. Biol. 23: 2151-2161 [Abstract] [Full Text]  
  • Hodge, J. C., Bub, J., Kaul, S., Kajdacsy-Balla, A., Lindholm, P. F. (2003). Requirement of RhoA Activity for Increased Nuclear Factor {kappa}B Activity and PC-3 Human Prostate Cancer Cell Invasion. Cancer Res. 63: 1359-1364 [Abstract] [Full Text]  
  • Svitkina, T. M., Bulanova, E. A., Chaga, O. Y., Vignjevic, D. M., Kojima, S.-i., Vasiliev, J. M., Borisy, G. G. (2003). Mechanism of filopodia initiation by reorganization of a dendritic network. JCB 160: 409-421 [Abstract] [Full Text]  
  • Abe, T., Kato, M., Miki, H., Takenawa, T., Endo, T. (2003). Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth. J. Cell Sci. 116: 155-168 [Abstract] [Full Text]  
  • Vidal, C., Geny, B., Melle, J., Jandrot-Perrus, M., Fontenay-Roupie, M. (2002). Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin. Blood 100: 4462-4469 [Abstract] [Full Text]  
  • Wennerberg, K., Ellerbroek, S. M., Liu, R.-Y., Karnoub, A. E., Burridge, K., Der, C. J. (2002). RhoG Signals in Parallel with Rac1 and Cdc42. J. Biol. Chem. 277: 47810-47817 [Abstract] [Full Text]  
  • Sakurada, K., Kato, H., Nagumo, H., Hiraoka, H., Furuya, K., Ikuhara, T., Yamakita, Y., Fukunaga, K., Miyamoto, E., Matsumura, F., Matsuo, Y.-I., Naito, Y., Sasaki, Y. (2002). Synapsin I Is Phosphorylated at Ser603 by p21-activated Kinases (PAKs) in Vitro and in PC12 Cells Stimulated with Bradykinin. J. Biol. Chem. 277: 45473-45479 [Abstract] [Full Text]  
  • Arthur, W. T., Ellerbroek, S. M., Der, C. J., Burridge, K., Wennerberg, K. (2002). XPLN, a Guanine Nucleotide Exchange Factor for RhoA and RhoB, But Not RhoC. J. Biol. Chem. 277: 42964-42972 [Abstract] [Full Text]  
  • Di Ciano, C., Nie, Z., Szaszi, K., Lewis, A., Uruno, T., Zhan, X., Rotstein, O. D., Mak, A., Kapus, A. (2002). Osmotic stress-induced remodeling of the cortical cytoskeleton. Am. J. Physiol. Cell Physiol. 283: C850-C865 [Abstract] [Full Text]  
  • Yanagawa, Y., Onoe, K. (2002). CCL19 induces rapid dendritic extension of murine dendritic cells. Blood 100: 1948-1956 [Abstract] [Full Text]  
  • Bao, W., Thullberg, M., Zhang, H., Onischenko, A., Stromblad, S. (2002). Cell Attachment to the Extracellular Matrix Induces Proteasomal Degradation of p21CIP1 via Cdc42/Rac1 Signaling. Mol. Cell. Biol. 22: 4587-4597 [Abstract] [Full Text]  
  • Masuda, T.-a., Inoue, H., Sonoda, H., Mine, S., Yoshikawa, Y., Nakayama, K., Nakayama, K.-I., Mori, M. (2002). Clinical and Biological Significance of S-Phase Kinase-associated Protein 2 (Skp2) Gene Expression in Gastric Carcinoma: Modulation of Malignant Phenotype by Skp2 Overexpression, Possibly via p27 Proteolysis. Cancer Res. 62: 3819-3825 [Abstract] [Full Text]  
  • Kanzaki, M., Watson, R. T., Hou, J. C., Stamnes, M., Saltiel, A. R., Pessin, J. E. (2002). Small GTP-binding Protein TC10 Differentially Regulates Two Distinct Populations of Filamentous Actin in 3T3L1 Adipocytes. Mol. Biol. Cell 13: 2334-2346 [Abstract] [Full Text]  
  • Kulkarni, S., Goll, D. E., Fox, J. E. B. (2002). Calpain Cleaves RhoA Generating a Dominant-negative Form That Inhibits Integrin-induced Actin Filament Assembly and Cell Spreading. J. Biol. Chem. 277: 24435-24441 [Abstract] [Full Text]  
  • Swart-Mataraza, J. M., Li, Z., Sacks, D. B. (2002). IQGAP1 Is a Component of Cdc42 Signaling to the Cytoskeleton. J. Biol. Chem. 277: 24753-24763 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»