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Mol. Cell. Biol., 06 1996, 2554-2560, Vol 16, No. 6
Copyright © 1996, American Society for Microbiology

Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit

RM Zwijsen, R Klompmaker, EB Wientjens, PM Kristel, B van der Burg and RJ Michalides
Department of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Cyclin D1 controls G1-associated processes, including G0-to-G1 and G1- to-S transitions. This study demonstrates a novel aspect of cyclin D1 as a regulator of the transition between G1 and G0. Overexpression of cyclin D1 in MCF7 breast tumor cells resulted in a continued proliferation under low-serum conditions, whereas nonoverexpressing cells ceased to grow. This difference in growth was due to a reduced exit from G1 to G0 in cyclin D1-overexpressing cells. Our data therefore suggest a model in which cyclin D1 overexpression in tumor cells is responsible for hyperproliferation under growth factor- deprived conditions.


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