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Mol. Cell. Biol., 08 1996, 4107-4116, Vol 16, No. 8
Copyright © 1996, American Society for Microbiology

Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

TR Golub, A Goga, GF Barker, DE Afar, J McLaughlin, SK Bohlander, JD Rowley, ON Witte and DG Gilliland
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

TEL is a member of the Ets family of transcription factors which are frequently rearranged in human leukemia. The mechanism of TEL-mediated transformation, however, is unknown. We report the cloning and characterization of a chromosomal translocation associated with acute myeloid leukemia which fuses TEL to the ABL tyrosine kinase. The TEL- ABL fusion confers growth factor-independent growth to the marine hematopoietic cell line Ba/F3 and transforms Rat-1 fibroblasts and primary murine bone marrow cells. TEL-ABL is constitutively tyrosine phosphorylated and localizes to the cytoskeleton. A TEL-ABL mutant containing an ABL kinase-inactivating mutation is not constitutively phosphorylated and is nontransforming but retains cytoskeletal localization. However, constitutive phosphorylation, cytoskeletal localization, and transformation are all dependent upon a highly conserved region of TEL termed the helix-loop-helix (HLH) domain. TEL- ABL formed HLH-dependent homo-oligomers in vitro, a process critical for tyrosine kinase activation. These experiments suggest that oligomerization of TEL-ABL mediated by the TEL HLH domain is required for tyrosine kinase activation, cytoskeletal localization, and transformation. These data also suggest that oligomerization of Ets proteins through the highly conserved HLH domain may represent a previously unrecognized phenomenon.


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  • Kas, K., Finger, E., Grall, F., Gu, X., Akbarali, Y., Boltax, J., Weiss, A., Oettgen, P., Kapeller, R., Libermann, T. A. (2000). ESE-3, a Novel Member of an Epithelium-specific Ets Transcription Factor Subfamily, Demonstrates Different Target Gene Specificity from ESE-1. J. Biol. Chem. 275: 2986-2998 [Abstract] [Full Text]  
  • Cazzaniga, G., Tosi, S., Aloisi, A., Giudici, G., Daniotti, M., Pioltelli, P., Kearney, L., Biondi, A. (1999). The Tyrosine Kinase Abl-Related Gene ARG Is Fused to ETV6 in an AML-M4Eo Patient With a t(1;12)(q25;p13): Molecular Cloning of Both Reciprocal Transcripts. Blood 94: 4370-4373 [Abstract] [Full Text]  
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  • Lopez, R. G., Carron, C., Oury, C., Gardellin, P., Bernard, O., Ghysdael, J. (1999). TEL Is a Sequence-specific Transcriptional Repressor. J. Biol. Chem. 274: 30132-30138 [Abstract] [Full Text]  
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  • Fenrick, R., Amann, J. M., Lutterbach, B., Wang, L., Westendorf, J. J., Downing, J. R., Hiebert, S. W. (1999). Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein. Mol. Cell. Biol. 19: 6566-6574 [Abstract] [Full Text]  
  • Gross, A. W., Zhang, X., Ren, R. (1999). Bcr-Abl with an SH3 Deletion Retains the Ability To Induce a Myeloproliferative Disease in Mice, yet c-Abl Activated by an SH3 Deletion Induces Only Lymphoid Malignancy. Mol. Cell. Biol. 19: 6918-6928 [Abstract] [Full Text]  
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  • Ross, T. S., Gilliland, D. G. (1999). Transforming Properties of the Huntingtin Interacting Protein 1/ Platelet-derived Growth Factor beta Receptor Fusion Protein. J. Biol. Chem. 274: 22328-22336 [Abstract] [Full Text]  
  • Ho, J. M.-Y., Beattie, B. K., Squire, J. A., Frank, D. A., Barber, D. L. (1999). Fusion of the ets Transcription Factor TEL to Jak2 Results in Constitutive Jak-Stat Signaling. Blood 93: 4354-4364 [Abstract] [Full Text]  
  • Beaupre, D. M., Kurzrock, R. (1999). RAS and Leukemia: From Basic Mechanisms to Gene-Directed Therapy. JCO 17: 1071-1071 [Abstract] [Full Text]  
  • Till, J. H., Chan, P. M., Miller, W. T. (1999). Engineering the Substrate Specificity of the Abl Tyrosine Kinase. J. Biol. Chem. 274: 4995-5003 [Abstract] [Full Text]  
  • Eguchi, M., Eguchi-Ishimae, M., Tojo, A., Morishita, K., Suzuki, K., Sato, Y., Kudoh, S., Tanaka, K., Setoyama, M., Nagamura, F., Asano, S., Kamada, N. (1999). Fusion of ETV6 to Neurotrophin-3 Receptor TRKC in Acute Myeloid Leukemia With t(12;15)(p13;q25). Blood 93: 1355-1363 [Abstract] [Full Text]  
  • Wei, Z., Angerer, R. C., Angerer, L. M. (1999). Identification of a New Sea Urchin Ets Protein, SpEts4, by Yeast One-Hybrid Screening with the Hatching Enzyme Promoter. Mol. Cell. Biol. 19: 1271-1278 [Abstract] [Full Text]  
  • Chase, A., Reiter, A., Burci, L., Cazzaniga, G., Biondi, A., Pickard, J., Roberts, I. A.G., Goldman, J. M., Cross, N. C.P. (1999). Fusion of ETV6 to the Caudal-Related Homeobox Gene CDX2 in Acute Myeloid Leukemia With the t(12;13)(p13;q12). Blood 93: 1025-1031 [Abstract] [Full Text]  
  • Corey, S. J., Anderson, S. M. (1999). Src-Related Protein Tyrosine Kinases in Hematopoiesis. Blood 93: 1-14 [Full Text]  
  • Okuda, K., D'Andrea, A., Van Etten, R.A., Griffin, J.D. (1998). The C-Terminus of c-Abl Is Required for Proliferation and Viability Signaling in a c-Abl/Erythropoietin Receptor Fusion Protein. Blood 92: 3848-3856 [Abstract] [Full Text]  
  • Rubin, B. P., Chen, C.-J., Morgan, T. W., Xiao, S., Grier, H. E., Kozakewich, H. P., Perez-Atayde, A. R., Fletcher, J. A. (1998). Congenital Mesoblastic Nephroma t(12;15) Is Associated with ETV6-NTRK3 Gene Fusion : Cytogenetic and Molecular Relationship to Congenital (Infantile)Fibrosarcoma. Am. J. Pathol. 153: 1451-1458 [Abstract] [Full Text]  
  • Slupsky, C. M., Gentile, L. N., Donaldson, L. W., Mackereth, C. D., Seidel, J. J., Graves, B. J., McIntosh, L. P. (1998). Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site. Proc. Natl. Acad. Sci. USA 95: 12129-12134 [Abstract] [Full Text]  
  • Reiter, A., Sohal, J., Kulkarni, S., Chase, A., Macdonald, D. H.C., Aguiar, R. C.T., Goncalves, C., Hernandez, J. M., Jennings, B. A., Goldman, J. M., Cross, N. C.P. (1998). Consistent Fusion of ZNF198 to the Fibroblast Growth Factor Receptor-1 in the t(8;13)(p11;q12) Myeloproliferative Syndrome. Blood 92: 1735-1742 [Abstract] [Full Text]  
  • Wang, L. C., Swat, W., Fujiwara, Y., Davidson, L., Visvader, J., Kuo, F., Alt, F. W., Gilliland, D. G., Golub, T. R., Orkin, S. H. (1998). The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 12: 2392-2402 [Abstract] [Full Text]  
  • Ross, T. S., Bernard, O. A., Berger, R., Gilliland, D. G. (1998). Fusion of Huntingtin Interacting Protein 1 to Platelet-Derived Growth Factor beta  Receptor (PDGFbeta R) in Chronic Myelomonocytic Leukemia With t(5;7)(q33;q11.2). Blood 91: 4419-4426 [Abstract] [Full Text]  
  • Bourgeade, M.-F., Defachelles, A.-S., Cayre, Y. E. (1998). Myc Is Essential for Transformation by TEL/Platelet-Derived Growth Factor Receptor beta  (PDGFRbeta ). Blood 91: 3333-3339 [Abstract] [Full Text]  
  • Wlodarska, I., La Starza, R., Baens, M., Dierlamm, J., Uyttebroeck, A., Selleslag, D., Francine, A., Mecucci, C., Hagemeijer, A., Van den Berghe, H., Marynen, P. (1998). Fluorescence In Situ Hybridization Characterization of New Translocations Involving TEL (ETV6) in a Wide Spectrum of Hematologic Malignancies. Blood 91: 1399-1406 [Abstract] [Full Text]  
  • Sato, Y., Bohlander, S. K., Kobayashi, H., Reshmi, S., Suto, Y., Davis, E. M., Espinosa III, R., Hoopes, R., Montgomery, K. T., Kucherlapati, R. S., Le Beau, M. M., Rowley, J. D. (1997). Heterogeneity in the Breakpoints in Balanced Rearrangements Involving Band 12p13 in Hematologic Malignancies Identified by Fluorescence In Situ Hybridization: TEL (ETV6 ) Is Involved in Only One Half. Blood 90: 4886-4893 [Abstract] [Full Text]  
  • Lacronique, V., Boureux, A., Della Valle, V., Poirel, H., Quang, C. T., Mauchauffé, M., Berthou, C., Lessard, M., Berger, R., Ghysdael, J., Bernard, O. A. (1997). A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia. Science 278: 1309-1312 [Abstract] [Full Text]  
  • Peeters, P., Raynaud, S. D., Cools, J., Wlodarska, I., Grosgeorge, J., Philip, P., Monpoux, F., Van Rompaey, L., Baens, M., Van den Berghe, H., Marynen, P. (1997). Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia. Blood 90: 2535-2540 [Abstract] [Full Text]  
  • Read, R. D., Lionberger, J. M., Smithgall, T. E. (1997). Oligomerization of the Fes Tyrosine Kinase. EVIDENCE FOR A COILED-COIL DOMAIN IN THE UNIQUE N-TERMINAL REGION. J. Biol. Chem. 272: 18498-18503 [Abstract] [Full Text]  
  • Carroll, M., Tomasson, M. H., Barker, G. F., Golub, T. R., Gilliland, D. G. (1996). The TEL/platelet-derived growth factor beta  receptor (PDGFbeta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFbeta R kinase-dependent signaling pathways. Proc. Natl. Acad. Sci. USA 93: 14845-14850 [Abstract] [Full Text]  
  • Sattler, M., Verma, S., Pride, Y. B., Salgia, R., Rohrschneider, L. R., Griffin, J. D. (2001). SHIP1, an SH2 Domain Containing Polyinositol-5-phosphatase, Regulates Migration through Two Critical Tyrosine Residues and Forms a Novel Signaling Complex with DOK1 and CRKL. J. Biol. Chem. 276: 2451-2458 [Abstract] [Full Text]  
  • Gu, X., Shin, B.-H., Akbarali, Y., Weiss, A., Boltax, J., Oettgen, P., Libermann, T. A. (2001). Tel-2 Is a Novel Transcriptional Repressor Related to the Ets Factor Tel/ETV-6. J. Biol. Chem. 276: 9421-9436 [Abstract] [Full Text]  
  • Smith, K. M., Van Etten, R. A. (2001). Activation of c-Abl Kinase Activity and Transformation by a Chemical Inducer of Dimerization. J. Biol. Chem. 276: 24372-24379 [Abstract] [Full Text]  
  • Nguyen, M. H.-H., Ho, J. M.-Y., Beattie, B. K., Barber, D. L. (2001). TEL-JAK2 Mediates Constitutive Activation of the Phosphatidylinositol 3'-Kinase/Protein Kinase B Signaling Pathway. J. Biol. Chem. 276: 32704-32713 [Abstract] [Full Text]  
  • Salomon-Nguyen, F., Della-Valle, V., Mauchauffe, M., Busson-Le Coniat, M., Ghysdael, J., Berger, R., Bernard, O. A. (2000). The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion. Proc. Natl. Acad. Sci. USA 97: 6757-6762 [Abstract] [Full Text]  


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