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Mol. Cell. Biol., Aug 1996, 4555-4565, Vol 16, No. 8
Copyright © 1996, American Society for Microbiology

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

PM Vertino, RW Yen, J Gao and SB Baylin
Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

Recent studies showing a correlation between the levels of DNA (cytosine-5-)-methyltransferase (DNA MTase) enzyme activity and tumorigenicity have implicated this enzyme in the carcinogenic process. Moreover, hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor initiation and progression. One proposed role for DNA MTase in tumorigenesis is therefore a direct role in the de novo methylation of these otherwise unmethylated CpG islands. In this study, we sought to determine whether increased levels of DNA MTase could directly affect CpG island methylation. A full-length cDNA for human DNA MTase driven by the cytomegalovirus promoter was constitutively expressed in human fibroblasts. Individual clones derived from cells transfected with DNA MTase (HMT) expressed 1- to 50-fold the level of DNA MTase protein and enzyme activity of the parental cell line or clones transfected with the control vector alone (Neo). To determine the effects of DNA MTase overexpression on CpG island methylation, we examined 12 endogenous CpG island loci in the HMT clones. HMT clones expressing > or = 9-fold the parental levels of DNA MTase activity were significantly hypermethylated relative to at least 11 Neo clones at five CpG island loci. In the HMT clones, methylation reached nearly 100% at susceptible CpG island loci with time in culture. In contrast, there was little change in the methylation status in the Neo clones over the same time frame. Taken together, the data indicate that overexpression of DNA MTase can drive the de novo methylation of susceptible CpG island loci, thus providing support for the idea that DNA MTase can contribute to tumor progression through CpG island methylation-mediated gene inactivation.


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  • Robertson, K. D., Keyomarsi, K., Gonzales, F. A., Velicescu, M., Jones, P. A. (2000). Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells. Nucleic Acids Res 28: 2108-2113 [Abstract] [Full Text]  
  • Robertson, K. D., A.Jones, P. (2000). DNA methylation: past, present and future directions. Carcinogenesis 21: 461-467 [Abstract] [Full Text]  
  • Li, L.-C., Chui, R., Nakajima, K., Oh, B. R., Au, H. C., Dahiya, R. (2000). Frequent Methylation of Estrogen Receptor in Prostate Cancer: Correlation with Tumor Progression. Cancer Res. 60: 702-706 [Abstract] [Full Text]  
  • Hsieh, C.-L. (1999). In Vivo Activity of Murine De Novo Methyltransferases, Dnmt3a and Dnmt3b. Mol. Cell. Biol. 19: 8211-8218 [Abstract] [Full Text]  
  • Cameron, E. E., Baylin, S. B., Herman, J. G. (1999). p15INK4B CpG Island Methylation in Primary Acute Leukemia Is Heterogeneous and Suggests Density as a Critical Factor for Transcriptional Silencing. Blood 94: 2445-2451 [Abstract] [Full Text]  
  • Hsu, D.-W., Lin, M.-J., Lee, T.-L., Wen, S.-C., Chen, X., Shen, C.-K. J. (1999). Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues. Proc. Natl. Acad. Sci. USA 96: 9751-9756 [Abstract] [Full Text]  
  • Wong, D. J., Foster, S. A., Galloway, D. A., Reid, B. J. (1999). Progressive Region-Specific De Novo Methylation of the p16 CpG Island in Primary Human Mammary Epithelial Cell Strains during Escape from M0 Growth Arrest. Mol. Cell. Biol. 19: 5642-5651 [Abstract] [Full Text]  
  • De Marzo, A. M., Marchi, V. L., Yang, E. S., Veeraswamy, R., Lin, X., Nelson, W. G. (1999). Abnormal Regulation of DNA Methyltransferase Expression during Colorectal Carcinogenesis. Cancer Res. 59: 3855-3860 [Abstract] [Full Text]  
  • Toyota, M., Ahuja, N., Ohe-Toyota, M., Herman, J. G., Baylin, S. B., Issa, J.-P. J. (1999). CpG island methylator phenotype in colorectal cancer. Proc. Natl. Acad. Sci. USA 96: 8681-8686 [Abstract] [Full Text]  
  • Slack, A., Cervoni, N., Pinard, M., Szyf, M. (1999). DNA Methyltransferase Is a Downstream Effector of Cellular Transformation Triggered by Simian Virus 40 Large T Antigen. J. Biol. Chem. 274: 10105-10112 [Abstract] [Full Text]  
  • Bakin, A. V., Curran, T. (1999). Role of DNA 5-Methylcytosine Transferase in Cell Transformation by fos. Science 283: 387-390 [Abstract] [Full Text]  
  • Mikovits, J. A., Young, H. A., Vertino, P., Issa, J.-P. J., Pitha, P. M., Turcoski-Corrales, S., Taub, D. D., Petrow, C. L., Baylin, S. B., Ruscetti, F. W. (1998). Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-gamma ) Promoter and Subsequent Downregulation of IFN-gamma Production. Mol. Cell. Biol. 18: 5166-5177 [Abstract] [Full Text]  
  • Holliday, R., Ho, T. (1998). Evidence for gene silencing by endogenous DNA methylation. Proc. Natl. Acad. Sci. USA 95: 8727-8732 [Abstract] [Full Text]  
  • Ferguson, A. T., Vertino, P. M., Spitzner, J. R., Baylin, S. B., Muller, M. T., Davidson, N. E. (1997). Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2'deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells. J. Biol. Chem. 272: 32260-32266 [Abstract] [Full Text]  
  • Graff, J. R., Herman, J. G., Myohanen, S., Baylin, S. B., Vertino, P. M. (1997). Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions in de Novo Methylation. J. Biol. Chem. 272: 22322-22329 [Abstract] [Full Text]  
  • Yoder, J. A., Yen, R.-W. C., Vertino, P. M., Bestor, T. H., Baylin, S. B. (1996). New 5' Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase. J. Biol. Chem. 271: 31092-31097 [Abstract] [Full Text]  
  • Tucker, K. L., Talbot, D., Lee, M. A., Leonhardt, H., Jaenisch, R. (1996). Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene. Proc. Natl. Acad. Sci. USA 93: 12920-12925 [Abstract] [Full Text]  
  • Detich, N., Ramchandani, S., Szyf, M. (2001). A Conserved 3'-Untranslated Element Mediates Growth Regulation of DNA Methyltransferase 1 and Inhibits Its Transforming Activity. J. Biol. Chem. 276: 24881-24890 [Abstract] [Full Text]  


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