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Mol. Cell. Biol., Dec 1997, 6940-6947, Vol 17, No. 12
Copyright © 1997, American Society for Microbiology

Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A

H Imataka and N Sonenberg
Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec, Canada.

Mammalian translation initiation factor 4F (eIF4F) consists of three subunits, eIF4A, eIF4E, and eIF4G. eIF4G interacts directly with both eIF4A and eIF4E. The binding site for eIF4E is contained in the amino- terminal third of eIF4G, while the binding site for eIF4A was mapped to the carboxy-terminal third of the molecule. Here we show that human eIF4G possesses two separate eIF4A binding domains in the middle third (amino acids [aa] 478 to 883) and carboxy-terminal third (aa 884 to 1404) of the molecule. The amino acid sequence of the middle portion of eIF4G is well conserved between yeasts and humans. We show that mutations of conserved amino acid stretches in the middle domain abolish or reduce eIF4A binding as well as eIF3 binding. In addition, a separate and nonoverlapping eIF4A binding domain exists in the carboxy- terminal third (aa 1045 to 1404) of eIF4G, which is not present in yeast. The C-terminal two-thirds region (aa 457 to 1404) of eIF4G, containing both eIF4A binding sites, is required for stimulating translation. Neither one of the eIF4A binding domains alone activates translation. In contrast to eIF4G, human p97, a translation inhibitor with homology to eIF4G, binds eIF4A only through the amino-terminal proximal region, which is homologous to the middle domain of eIF4G.


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  • Elgadi, M. M., Smiley, J. R. (1999). Picornavirus Internal Ribosome Entry Site Elements Target RNA Cleavage Events Induced by the Herpes Simplex Virus Virion Host Shutoff Protein. J. Virol. 73: 9222-9231 [Abstract] [Full Text]  
  • Li, Q., Imataka, H., Morino, S., Rogers, G. W. Jr., Richter-Cook, N. J., Merrick, W. C., Sonenberg, N. (1999). Eukaryotic Translation Initiation Factor 4AIII (eIF4AIII) Is Functionally Distinct from eIF4AI and eIF4AII. Mol. Cell. Biol. 19: 7336-7346 [Abstract] [Full Text]  
  • Dominguez, D., Altmann, M., Benz, J., Baumann, U., Trachsel, H. (1999). Interaction of Translation Initiation Factor eIF4G with eIF4A in the Yeast Saccharomyces cerevisiae. J. Biol. Chem. 274: 26720-26726 [Abstract] [Full Text]  
  • Neff, C. L., Sachs, A. B. (1999). Eukaryotic Translation Initiation Factors 4G and 4A from Saccharomyces cerevisiae Interact Physically and Functionally. Mol. Cell. Biol. 19: 5557-5564 [Abstract] [Full Text]  
  • Hershey, P. E. C., McWhirter, S. M., Gross, J. D., Wagner, G., Alber, T., Sachs, A. B. (1999). The Cap-binding Protein eIF4E Promotes Folding of a Functional Domain of Yeast Translation Initiation Factor eIF4G1. J. Biol. Chem. 274: 21297-21304 [Abstract] [Full Text]  
  • Kim, C.-Y., Takahashi, K., Nguyen, T. B., Roberts, J. K. M., Webster, C. (1999). Identification of a Nucleic Acid Binding Domain in Eukaryotic Initiation Factor eIFiso4G from Wheat. J. Biol. Chem. 274: 10603-10608 [Abstract] [Full Text]  
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  • McCarthy, J. E. G. (1998). Posttranscriptional Control of Gene Expression in Yeast. Microbiol. Mol. Biol. Rev. 62: 1492-1553 [Abstract] [Full Text]  
  • Gradi, A., Svitkin, Y. V., Imataka, H., Sonenberg, N. (1998). Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proc. Natl. Acad. Sci. USA 95: 11089-11094 [Abstract] [Full Text]  
  • Asano, K., Phan, L., Anderson, J., Hinnebusch, A. G. (1998). Complex Formation by All Five Homologues of Mammalian Translation Initiation Factor 3 Subunits from Yeast Saccharomyces cerevisiae. J. Biol. Chem. 273: 18573-18585 [Abstract] [Full Text]  
  • Kolupaeva, V. G., Pestova, T. V., Hellen, C. U. T., Shatsky, I. N. (1998). Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA. J. Biol. Chem. 273: 18599-18604 [Abstract] [Full Text]  
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