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Mol. Cell. Biol., Mar 1997, 1476-1483, Vol 17, No. 3
Copyright © 1997, American Society for Microbiology

DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita

M Ito, R Yu and JL Jameson
Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA.

X-linked adrenal hypoplasia congenita (AHC) with hypogonadotropic hypogonadism was recently shown to be caused by mutations in a gene referred to as DAX-1, which encodes a novel member of the orphan nuclear receptor family. DAX-1 is homologous to other nuclear receptors in its carboxy-terminal region, but it lacks the characteristic zinc finger DNA-binding domain. The tissue distribution of DAX-1 (adrenal cortex, gonads, hypothalamus, and pituitary) is the same as that of another orphan nuclear receptor, steroidogenic factor 1 (SF-1), that is required for development of the adrenal glands and gonads. We examined whether DAX-1 and SF-1 might interact in the regulation of SF-1- responsive target genes. Coexpression of DAX-1 and SF-1 inhibited SF-1- mediated transactivation. DAX-1 was shown to interact directly with SF- 1 in in vitro protein binding studies; however, it did not interfere with SF-1 binding to DNA in gel mobility shift assays. Transactivation by GAL4-SF-1 constructs was inhibited by DAX-1, indicating that neither the SF-1 DNA-binding domain nor the SF-1 binding sites are required for inhibition by DAX-1. A series of DAX-1 deletion mutants localized the inhibitory domain to the carboxy-terminal region of the protein. Deletion of this domain also reduced basal transcriptional silencing by GAL4-DAX-1. This inhibitory domain has been deleted in all naturally occurring AHC deletion mutants described to date. In addition, two naturally occurring point mutations in DAX-1 exhibited impaired inhibition of SF-1. We conclude that DAX-1 can inhibit SF-1 transcriptional activity and suggest that the loss of this inhibitory property in DAX-1 may account in part for the phenotype of AHC.


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  • MacLaughlin, D. T., Donahoe, P. K. (2004). Sex Determination and Differentiation. NEJM 350: 367-378 [Full Text]  
  • Fan, W., Yanase, T., Wu, Y., Kawate, H., Saitoh, M., Oba, K., Nomura, M., Okabe, T., Goto, K., Yanagisawa, J., Kato, S., Takayanagi, R., Nawata, H. (2004). Protein Kinase A Potentiates Adrenal 4 Binding Protein/Steroidogenic Factor 1 Transactivation by Reintegrating the Subcellular Dynamic Interactions of the Nuclear Receptor with Its Cofactors, General Control Nonderepressed-5/Transformation/ Transcription Domain-Associated Protein, and Suppressor, Dosage-Sensitive Sex Reversal-1: a Laser Confocal Imaging Study in Living KGN Cells. Mol. Endocrinol. 18: 127-141 [Abstract] [Full Text]  
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  • Lalli, E., Sassone-Corsi, P. (2003). DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual Differentiation. Mol. Endocrinol. 17: 1445-1453 [Abstract] [Full Text]  
  • Gummow, B. M., Winnay, J. N., Hammer, G. D. (2003). Convergence of Wnt Signaling and Steroidogenic Factor-1 (SF-1) on Transcription of the Rat Inhibin {alpha} Gene. J. Biol. Chem. 278: 26572-26579 [Abstract] [Full Text]  
  • Ghosh, A. K., Steele, R., Ray, R. B. (2003). Modulation of Human Luteinizing Hormone {beta} Gene Transcription by MIP-2A. J. Biol. Chem. 278: 24033-24038 [Abstract] [Full Text]  
  • Kawajiri, K., Ikuta, T., Suzuki, T., Kusaka, M., Muramatsu, M., Fujieda, K., Tachibana, M., Morohashi, K.-i. (2003). Role of the LXXLL-Motif and Activation Function 2 Domain in Subcellular Localization of Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1). Mol. Endocrinol. 17: 994-1004 [Abstract] [Full Text]  
  • Lehmann, S. G., Wurtz, J.-M., Renaud, J.-P., Sassone-Corsi, P., Lalli, E. (2003). Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients. Hum Mol Genet 12: 1063-1072 [Abstract] [Full Text]  
  • Yazawa, T., Mizutani, T., Yamada, K., Kawata, H., Sekiguchi, T., Yoshino, M., Kajitani, T., Shou, Z., Miyamoto, K. (2003). Involvement of Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein, Steroidogenic Factor 1, and Dax-1 in the Regulation of Gonadotropin-Inducible Ovarian Transcription Factor 1 Gene Expression by Follicle-Stimulating Hormone in Ovarian Granulosa Cells. Endocrinology 144: 1920-1930 [Abstract] [Full Text]  
  • Mizusaki, H., Kawabe, K., Mukai, T., Ariyoshi, E., Kasahara, M., Yoshioka, H., Swain, A., Morohashi, K.-i. (2003). Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1) Gene Transcription Is Regulated by Wnt4 in the Female Developing Gonad. Mol. Endocrinol. 17: 507-519 [Abstract] [Full Text]  
  • Brown, P., Scobie, G. A., Townsend, J., Bayne, R. A. L., Seckl, J. R., Saunders, P. T. K., Anderson, R. A. (2003). Identification of a Novel Missense Mutation That Is as Damaging to DAX-1 Repressor Function as a Nonsense Mutation. J. Clin. Endocrinol. Metab. 88: 1341-1349 [Abstract] [Full Text]  
  • Meeks, J. J., Crawford, S. E., Russell, T. A., Morohashi, K.-i., Weiss, J., Jameson, J. L. (2003). Dax1 regulates testis cord organization during gonadal differentiation. Development 130: 1029-1036 [Abstract] [Full Text]  
  • Zhang, Y., Kast-Woelbern, H. R., Edwards, P. A. (2003). Natural Structural Variants of the Nuclear Receptor Farnesoid X Receptor Affect Transcriptional Activation. J. Biol. Chem. 278: 104-110 [Abstract] [Full Text]  
  • Suzuki, T., Kasahara, M., Yoshioka, H., Morohashi, K.-i., Umesono, K. (2003). LXXLL-Related Motifs in Dax-1 Have Target Specificity for the Orphan Nuclear Receptors Ad4BP/SF-1 and LRH-1. Mol. Cell. Biol. 23: 238-249 [Abstract] [Full Text]  
  • Yan, X., Mouillet, J.-F., Ou, Q., Sadovsky, Y. (2003). A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity. Mol. Cell. Biol. 23: 414-423 [Abstract] [Full Text]  
  • Ozisik, G., Mantovani, G., Achermann, J. C., Persani, L., Spada, A., Weiss, J., Beck-Peccoz, P., Jameson, J. L. (2003). An Alternate Translation Initiation Site Circumvents an Amino-Terminal DAX1 Nonsense Mutation Leading to a Mild Form of X-Linked Adrenal Hypoplasia Congenita. J. Clin. Endocrinol. Metab. 88: 417-423 [Abstract] [Full Text]  
  • Wei, X., Sasaki, M., Huang, H., Dawson, V. L., Dawson, T. M. (2002). The Orphan Nuclear Receptor, Steroidogenic Factor 1, Regulates Neuronal Nitric Oxide Synthase Gene Expression in Pituitary Gonadotropes. Mol. Endocrinol. 16: 2828-2839 [Abstract] [Full Text]  
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  • Brendel, C., Schoonjans, K., Botrugno, O. A., Treuter, E., Auwerx, J. (2002). The Small Heterodimer Partner Interacts with the Liver X Receptor {alpha} and Represses Its Transcriptional Activity. Mol. Endocrinol. 16: 2065-2076 [Abstract] [Full Text]  
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  • Lehmann, S. G., Lalli, E., Sassone-Corsi, P. (2002). From the Cover: X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein. Proc. Natl. Acad. Sci. USA 99: 8225-8230 [Abstract] [Full Text]  
  • Seminara, S. B., Crowley, W. F. Jr. (2002). Genetic Approaches to Unraveling Reproductive Disorders: Examples of Bedside to Bench Research in the Genomic Era. Endocr. Rev. 23: 382-392 [Abstract] [Full Text]  
  • Hoyle, C., Narvaez, V., Alldus, G., Lovell-Badge, R., Swain, A. (2002). Dax1 Expression Is Dependent on Steroidogenic Factor 1 in the Developing Gonad. Mol. Endocrinol. 16: 747-756 [Abstract] [Full Text]  
  • Holter, E., Kotaja, N., Makela, S., Strauss, L., Kietz, S., Janne, O. A., Gustafsson, J.-A., Palvimo, J. J., Treuter, E. (2002). Inhibition of Androgen Receptor (AR) Function by the Reproductive Orphan Nuclear Receptor DAX-1. Mol. Endocrinol. 16: 515-528 [Abstract] [Full Text]  
  • Koskimies, P., Levallet, J., Sipila, P., Huhtaniemi, I., Poutanen, M. (2002). Murine Relaxin-Like Factor Promoter: Functional Characterization and Regulation by Transcription Factors Steroidogenic Factor 1 and DAX-1. Endocrinology 143: 909-919 [Abstract] [Full Text]  
  • Babu, P. S., Bavers, D. L., Beuschlein, F., Shah, S., Jeffs, B., Jameson, J. L., Hammer, G. D. (2002). Interaction Between Dax-1 and Steroidogenic Factor-1 in Vivo: Increased Adrenal Responsiveness to ACTH in the Absence of Dax-1. Endocrinology 143: 665-673 [Abstract] [Full Text]  
  • McCabe, E. R. B. (2002). Vulnerability within a Robust Complex System--DAX-1 Mutations and Steroidogenic Axis Development. J. Clin. Endocrinol. Metab. 87: 41-43 [Abstract] [Full Text]  
  • Mantovani, G., Ozisik, G., Achermann, J. C., Romoli, R., Borretta, G., Persani, L., Spada, A., Jameson, J. L., Beck-Peccoz, P. (2002). Hypogonadotropic Hypogonadism as a Presenting Feature of Late-Onset X-Linked Adrenal Hypoplasia Congenita. J. Clin. Endocrinol. Metab. 87: 44-48 [Abstract] [Full Text]  
  • Parker, K. L., Rice, D. A., Lala, D. S., Ikeda, Y., Luo, X., Wong, M., Bakke, M., Zhao, L., Frigeri, C., Hanley, N. A., Stallings, N., Schimmer, B. P. (2002). Steroidogenic Factor 1: an Essential Mediator of Endocrine Development. Recent Prog Horm Res 57: 19-36 [Abstract] [Full Text]  
  • Lopez, D., Shea-Eaton, W., Sanchez, M. D., McLean, M. P. (2001). DAX-1 Represses the High-Density Lipoprotein Receptor Through Interaction with Positive Regulators Sterol Regulatory Element-Binding Protein-1a and Steroidogenic Factor-1. Endocrinology 142: 5097-5106 [Abstract] [Full Text]  
  • Yuan, X., Lu, M. L., Li, T., Balk, S. P. (2001). SRY Interacts with and Negatively Regulates Androgen Receptor Transcriptional Activity. J. Biol. Chem. 276: 46647-46654 [Abstract] [Full Text]  
  • Stocco, D. M. (2001). Tracking the Role of a StAR in the Sky of the New Millennium. Mol. Endocrinol. 15: 1245-1254 [Abstract] [Full Text]  
  • Sugawara, T., Abe, S., Sakuragi, N., Fujimoto, Y., Nomura, E., Fujieda, K., Saito, M., Fujimoto, S. (2001). RIP 140 Modulates Transcription of the Steroidogenic Acute Regulatory Protein Gene through Interactions with Both SF-1 and DAX-1. Endocrinology 142: 3570-3577 [Abstract] [Full Text]  
  • Achermann, J. C., Ito, M., Silverman, B. L., Habiby, R. L., Pang, S., Rosler, A., Jameson, J. L. (2001). Missense Mutations Cluster within the Carboxyl-Terminal Region of DAX-1 and Impair Transcriptional Repression. J. Clin. Endocrinol. Metab. 86: 3171-3175 [Abstract] [Full Text]  
  • Wang, Z. J., Jeffs, B., Ito, M., Achermann, J. C., Yu, R. N., Hales, D. B., Jameson, J. L. (2001). Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1. Proc. Natl. Acad. Sci. USA 10.1073/pnas.141543298v1 [Abstract] [Full Text]  
  • Aylwin, S. J. B., Welch, J. P., Davey, C. L., Geddes, J. F., Wood, D. F., Besser, G. M., Grossman, A. B., Monson, J. P., Burrin, J. M. (2001). The Relationship between Steroidogenic Factor 1 and DAX-1 Expression and in Vitro Gonadotropin Secretion in Human Pituitary Adenomas. J. Clin. Endocrinol. Metab. 86: 2476-2483 [Abstract] [Full Text]  
  • Heckert, L. L. (2001). Activation of the Rat Follicle-Stimulating Hormone Receptor Promoter by Steroidogenic Factor 1 Is Blocked by Protein Kinase A and Requires Upstream Stimulatory Factor Binding to a Proximal E Box Element. Mol. Endocrinol. 15: 704-715 [Abstract] [Full Text]  
  • Tremblay, J. J., Viger, R. S. (2001). Nuclear Receptor Dax-1 Represses the Transcriptional Cooperation Between GATA-4 and SF-1 in Sertoli Cells. Biol. Reprod. 64: 1191-1199 [Abstract] [Full Text]  
  • Hanley, N. A., Rainey, W. E., Wilson, D. I., Ball, S. G., Parker, K. L. (2001). Expression Profiles of SF-1, DAX1, and CYP17 in the Human Fetal Adrenal Gland: Potential Interactions in Gene Regulation. Mol. Endocrinol. 15: 57-68 [Abstract] [Full Text]  
  • Ou, Q., Mouillet, J.-F., Yan, X., Dorn, C., Crawford, P. A., Sadovsky, Y. (2001). The DEAD Box Protein DP103 Is a Regulator of Steroidogenic Factor-1. Mol. Endocrinol. 15: 69-79 [Abstract] [Full Text]  
  • Levallet, J., Koskimies, P., Rahman, N., Huhtaniemi, I. (2001). The Promoter of Murine Follicle-Stimulating Hormone Receptor: Functional Characterization and Regulation by Transcription Factor Steroidogenic Factor 1. Mol. Endocrinol. 15: 80-92 [Abstract] [Full Text]  
  • Aigueperse, C., Val, P., Pacot, C., Darne, C., Lalli, E., Sassone-Corsi, P., Veyssiere, G., Jean, C., Martinez, A. (2001). SF-1 (Steroidogenic Factor-1), C/EBP{beta} (CCAAT/Enhancer Binding Protein), and Ubiquitous Transcription Factors NF1 (Nuclear Factor 1) and Sp1 (Selective Promoter Factor 1) Are Required for Regulation of the Mouse Aldose Reductase-Like Gene (AKR1B7) Expression in Adrenocortical Cells. Mol. Endocrinol. 15: 93-111 [Abstract] [Full Text]  
  • Huang, T.-J., Shirley Li, P. (2001). Dexamethasone Inhibits Luteinizing Hormone-Induced Synthesis of Steroidogenic Acute Regulatory Protein in Cultured Rat Preovulatory Follicles. Biol. Reprod. 64: 163-170 [Abstract] [Full Text]  
  • Bland, M. L., Jamieson, C. A. M., Akana, S. F., Bornstein, S. R., Eisenhofer, G., Dallman, M. F., Ingraham, H. A. (2000). Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response. Proc. Natl. Acad. Sci. USA 97: 14488-14493 [Abstract] [Full Text]  
  • Boerboom, D., Pilon, N., Behdjani, R., Silversides, D. W., Sirois, J. (2000). Expression and Regulation of Transcripts Encoding Two Members of the NR5A Nuclear Receptor Subfamily of Orphan Nuclear Receptors, Steroidogenic Factor-1 and NR5A2, in Equine Ovarian Cells during the Ovulatory Process. Endocrinology 141: 4647-4656 [Abstract] [Full Text]  
  • Lalli, E., Ohe, K., Hindelang, C., Sassone-Corsi, P. (2000). Orphan Receptor DAX-1 Is a Shuttling RNA Binding Protein Associated with Polyribosomes via mRNA. Mol. Cell. Biol. 20: 4910-4921 [Abstract] [Full Text]  


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