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Mol. Cell. Biol., 04 1997, 2136-2142, Vol 17, No. 4
Copyright © 1997, American Society for Microbiology

A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

ME Budd and JL Campbell
Braun Laboratories, California Institute of Technology, Pasadena 91125, USA.

We have recently described a new helicase, the Dna2 helicase, that is essential for yeast DNA replication. We now show that the yeast FEN-1 (yFEN-1) nuclease interacts genetically and biochemically with Dna2 helicase. FEN-1 is implicated in DNA replication and repair in yeast, and the mammalian homolog of yFEN-1 (DNase IV, FEN-1, or MF1) participates in Okazaki fragment maturation. Overproduction of yFEN-1, encoded by RAD27/RTH1, suppresses the temperature-sensitive growth of dna2-1 mutants. Overproduction of Dna2 suppresses the rad27/rth1 delta temperature-sensitive growth defect. dna2-1 rad27/rth1 delta double mutants are inviable, indicating that the mutations are synthetically lethal. The genetic interactions are likely due to direct physical interaction between the two proteins, since both epitope-tagged yFEN-1 and endogenous yFEN-1 coimmunopurify with tagged Dna2. The simplest interpretation of these data is that one of the roles of Dna2 helicase is associated with processing of Okazaki fragments.


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  • Frei, C, Gasser, S. (2000). RecQ-like helicases: the DNA replication checkpoint connection. J. Cell Sci. 113: 2641-2646 [Abstract]  
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  • Qiu, J., Qian, Y., Frank, P., Wintersberger, U., Shen, B. (1999). Saccharomyces cerevisiae RNase H(35) Functions in RNA Primer Removal during Lagging-Strand DNA Synthesis, Most Efficiently in Cooperation with Rad27 Nuclease. Mol. Cell. Biol. 19: 8361-8371 [Abstract] [Full Text]  
  • Gary, R., Park, M. S., Nolan, J. P., Cornelius, H. L., Kozyreva, O. G., Tran, H. T., Lobachev, K. S., Resnick, M. A., Gordenin, D. A. (1999). A Novel Role in DNA Metabolism for the Binding of Fen1/Rad27 to PCNA and Implications for Genetic Risk. Mol. Cell. Biol. 19: 5373-5382 [Abstract] [Full Text]  
  • White, P. J., Borts, R. H., Hirst, M. C. (1999). Stability of the Human Fragile X (CGG)n Triplet Repeat Array in Saccharomyces cerevisiae Deficient in Aspects of DNA Metabolism. Mol. Cell. Biol. 19: 5675-5684 [Abstract] [Full Text]  
  • Parenteau, J., Wellinger, R. J. (1999). Accumulation of Single-Stranded DNA and Destabilization of Telomeric Repeats in Yeast Mutant Strains Carrying a Deletion of RAD27. Mol. Cell. Biol. 19: 4143-4152 [Abstract] [Full Text]  
  • Rumbaugh, J. A., Henricksen, L. A., DeMott, M. S., Bambara, R. A. (1999). Cleavage of Substrates with Mismatched Nucleotides by Flap Endonuclease-1. IMPLICATIONS FOR MAMMALIAN OKAZAKI FRAGMENT PROCESSING. J. Biol. Chem. 274: 14602-14608 [Abstract] [Full Text]  
  • Formosa, T., Nittis, T. (1999). Dna2 Mutants Reveal Interactions with Dna Polymerase {alpha} and Ctf4, a Pol {alpha} Accessory Factor, and Show That Full Dna2 Helicase Activity Is Not Essential for Growth. Genetics 151: 1459-1470 [Abstract] [Full Text]  
  • Kim, C.-Y., Shen, B., Park, M. S., Olah, G. A. (1999). Structural Changes Measured by X-ray Scattering from Human Flap Endonuclease-1 Complexed with Mg2+ and Flap DNA Substrate. J. Biol. Chem. 274: 1233-1239 [Abstract] [Full Text]  
  • Bibikova, M., Wu, B., Chi, E., Kim, K.-H., Trautman, J. K., Carroll, D. (1998). Characterization of FEN-1 from Xenopus laevis. cDNA CLONING AND ROLE IN DNA METABOLISM. J. Biol. Chem. 273: 34222-34229 [Abstract] [Full Text]  
  • Frank, G., Qiu, J., Somsouk, M., Weng, Y., Somsouk, L., Nolan, J. P., Shen, B. (1998). Partial Functional Deficiency of E160D Flap Endonuclease-1 Mutant in Vitro and in Vivo Is Due to Defective Cleavage of DNA Substrates. J. Biol. Chem. 273: 33064-33072 [Abstract] [Full Text]  
  • Bae, S.-H., Choi, E., Lee, K.-H., Park, J. S., Lee, S.-H., Seo, Y.-S. (1998). Dna2 of Saccharomyces cerevisiae Possesses a Single-stranded DNA-specific Endonuclease Activity That Is Able to Act on Double-stranded DNA in the Presence of ATP. J. Biol. Chem. 273: 26880-26890 [Abstract] [Full Text]  
  • Gould, K. L., Burns, C. G., Feoktistova, A., Hu, C.-P., Pasion, S. G., Forsburg, S. L. (1998). Fission Yeast cdc24+ Encodes a Novel Replication Factor Required for Chromosome Integrity. Genetics 149: 1221-1233 [Abstract] [Full Text]  
  • Kokoska, R. J., Stefanovic, L., Tran, H. T., Resnick, M. A., Gordenin, D. A., Petes, T. D. (1998). Destabilization of Yeast Micro- and Minisatellite DNA Sequences by Mutations Affecting a Nuclease Involved in Okazaki Fragment Processing (rad27) and DNA Polymerase delta  (pol3-t). Mol. Cell. Biol. 18: 2779-2788 [Abstract] [Full Text]  
  • Murante, R. S., Henricksen, L. A., Bambara, R. A. (1998). Junction ribonuclease: An activity in Okazaki fragment processing. Proc. Natl. Acad. Sci. USA 95: 2244-2249 [Abstract] [Full Text]  
  • Fiorentino, D. F., Crabtree, G. R. (1997). Characterization of Saccharomyces cerevisiae dna2 Mutants Suggests a Role for the Helicase Late in S Phase. Mol. Biol. Cell 8: 2519-2537 [Abstract] [Full Text]  
  • Bae, S.-H., Seo, Y.-S. (2000). Characterization of the Enzymatic Properties of the Yeast Dna2 Helicase/Endonuclease Suggests a New Model for Okazaki Fragment Processing. J. Biol. Chem. 275: 38022-38031 [Abstract] [Full Text]  
  • Tom, S., Henricksen, L. A., Park, M. S., Bambara, R. A. (2001). DNA Ligase I and Proliferating Cell Nuclear Antigen Form a Functional Complex. J. Biol. Chem. 276: 24817-24825 [Abstract] [Full Text]  
  • Frank, G., Qiu, J., Zheng, L., Shen, B. (2001). Stimulation of Eukaryotic Flap Endonuclease-1 Activities by Proliferating Cell Nuclear Antigen (PCNA) Is Independent of Its in Vitro Interaction via a Consensus PCNA Binding Region. J. Biol. Chem. 276: 36295-36302 [Abstract] [Full Text]  
  • Budd, M. E., Choe, W.-c., Campbell, J. L. (2000). The Nuclease Activity of the Yeast Dna2 Protein, Which Is Related to the RecB-like Nucleases, Is Essential in Vivo. J. Biol. Chem. 275: 16518-16529 [Abstract] [Full Text]  
  • Henricksen, L. A., Tom, S., Liu, Y., Bambara, R. A. (2000). Inhibition of Flap Endonuclease 1 by Flap Secondary Structure and Relevance to Repeat Sequence Expansion. J. Biol. Chem. 275: 16420-16427 [Abstract] [Full Text]  


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