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Mol. Cell. Biol., 07 1997, 3687-3693, Vol 17, No. 7
Copyright © 1997, American Society for Microbiology

A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster

H Hao, DL Allen and PE Hardin
Department of Biology, Texas A & M University, College Station 77843- 3258, USA.

Genes expressed under circadian-clock control are found in organisms ranging from prokaryotes to humans. In Drosophila melanogaster, the period (per) gene, which is required for clock function, is transcribed in a circadian manner. We have identified a circadian transcriptional enhancer within a 69-bp DNA fragment upstream of the per gene. This enhancer drives high-amplitude mRNA cycling under light-dark-cycling or constant-dark conditions, and this activity is per protein (PER) dependent. An E-box sequence within this 69-bp fragment is necessary for high-level expression, but not for rhythmic expression, indicating that PER mediates circadian transcription through other sequences in this fragment.


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